- Tracy Nelson - Self
- Charlie Robison - Self
- Jonny Lang - Self
- Brad Paisley - Self
- John Hiatt - Self
- Junior Brown - Self
- Garth Brooks - Self
- Patty Loveless - Herself
- Michael Stipe - Self
- Charlie Daniels - Self
- Michael McDonald - Self
- Joe Nichols - Self
- Paolo Nutini - Self
- Manu Chao - Self
- Mary Chapin Carpenter - Self
- Leon Russell - Self
- Jakob Dylan - Self
- Jason Mraz - Self
- Juanes - Self
- Jimmy Buffett - Self
- Delbert McClinton - Self
- Guy Clark - Self
- Jewel - Self
- Trisha Yearwood - Self
- Jamie Cullum - Self
- Ray LaMontagne - Self
- Tift Merritt - Self
- Gretchen Wilson - Self
- Pinetop Perkins - Self
- Béla Fleck - Self
- Clint Black - Self
- Joe Cocker - Self
- Sheryl Crow - Self
- John Fogerty - Self
- Ray Price - Self
- David Byrne - Self
- Richard Thompson - Self
- Nick Lowe - Self
- Cat Power - Self
- Natalie Merchant - Self
- Clifton Chenier - Self
- Steven Fromholz - Self
- Deana Carter - Self
- Martina McBride - Self
- Susan Ashton - Self
- Shelby Lynne - Self
- David Gray - Self
- Jack Johnson - Self
- James Blunt - Self
- Allison Moorer - Self
- Doyle Bramhall II - Self
- Sufjan Stevens - Self
- Clay Walker - Self
- Kasey Chambers - Self
- Duffy - Self
- Etta James - Self
- Lee Ann Womack - Self
- Van Morrison - Self
- KT Tunstall - Self
- Kenny Rogers - Self
- Larry Gatlin - Self
- Tracy Chapman - Self
- Dave Alvin - Self
- Damian Marley - Self
- Boz Scaggs - Self
- Ruth Brown - Self
- Joe Ely - Self
- Fats Domino - Self
- Ben Harper - Self
- Elvis Costello - Self
- Trey Anastasio - Self
- Alison Krauss - Self
- John Mayer - Self
- Vince Gill - Self
- Robert Earl Keen - Self
- Dierks Bentley - Self
- Neko Case - Self
- Jessica Andrews - Self
- Kenneth C. 'Jethro' Burns - Self
- Augie Meyers - Self
- Ryan Adams - Self
- Clarence "Gatemouth" Brown - Self
- Lionel Hampton - Self
- Hank Thompson - Self
- Townes Van Zandt - Self
- Trace Adkins - Self
- Chuck Prophet - Self
- Marty Stuart - Self
- Joss Stone - Self
- Collin Raye - Himself
- Ben Folds - Self
- Corinne Bailey Rae - Self
- Robert Cray - Self
- Billy Bragg - Self
- Loudon Wainwright III - Self
- Mike Mills - Self
- Kim Wilson - Self
- Irma Thomas - Self
- Steve Goodman - Self
- Lisa Hartman - Self
- Charlie Louvin - Self
- Peter Buck - Self
- Freddy Fender - Self
- Pam Tillis - Self
- Earl Scruggs - Self
- Chris Smither - Self
- William Rieflin - Self
- Lou Ann Barton - Self
- Scott McCaughey - Self
- Bill Berry - Self
- Cesar Rosas - Self
- Nanci Griffith - Self
- Nanci Griffith - Self (archive footage)
- David Hidalgo - Self
- Teddy Thompson - Self
- Doug Sahm - Self
- Esperanza Spalding - Self
- Steve Winwood - Self
- Don Henley - Self
- Sturgill Simpson - Self
- Cassandra Wilson - Self
- Gillian Welch - Self
- Dwight Yoakam - Self
- Courtney Barnett - Self
- James Taylor - Self
- Robert Randolph - Self
- Buffy Sainte-Marie - Self
- Jeff Tweedy - Self
- Beck - Self
- Sam Smith - Self
- Brandi Carlile - Self
- Miguel - Self
- Alessia Cara - Self
- Kacey Musgraves - Self
- Lukas Nelson - Self
- Janelle Monáe - Self
- Whitney Coleman - Self - Background Vocals for Anderson East
- Kristin Wilkinson - Self - Viola for Anderson East
- Brendan Grieve - Self - Bass for Sam Smith
- Reuben James - Self - Piano for Sam Smith
- Lewis Allen - Self - Guitar for Sam Smith
- Lucy Jules - Self - Background Vocals for Sam Smith
- Kristin Brooks - Self - Background Vocals for Sam Smith
- Harry Robinson - Self - Background Vocals for Sam Smith
- Residente - Self
- Trombone Shorty - Self
- Khalid - Self
- John Hammond - Himself
- Mac DeMarco - Self
- Johnny Rodriguez - Self
- Gary Clark Jr. - Self
- Maggie Rogers - Self
- Kelley Looney - Self
- Chris Masterson - Self
- Eleanor Whitmore - Self
- Ricky Ray Jackson - Self
- Brad Pemberton - Self
- H.E.R. - Self
- Buddy Miller - Self
- Loretta Lynn - Self
- Jim Lauderdale - Self
- Rodney Crowell - Self
- Flaco Jiménez - Self
- Lyle Lovett - Self
- Kane Brown - Self
- Lucinda Williams - Self
- Rosanne Cash - Self
- Taj Mahal - Self
- Robert Plant - Self
- JD Souther - Self
- Don Was - Self
- Joachim Cooder - Self
- Jimmie Vaughan - Self
- Lucy Dacus - Self
- Sharon Van Etten - Self
- Mitski - Self
- Billie Eilish - Self
- Jack White - Self
- Brendan Benson - Self
- Eric Burton - Self
- Adrian Quesada - Self
- Bonnie Raitt - Self
- Rosalía - Self
- Ray Wylie Hubbard - Self
- Billy Joe Shaver - Self
- Bob Wills - Self
- Alvin Crow - Self
- Jerry Jeff Walker - Self
- Jon Batiste - Self
- Patty Griffin - Self
- Billy Strings - Self
- Valerie June - Self
- John Prine - Self
- John Prine - Self (archive footage)
- Brandy Clark - Self
- Ry Cooder - Self
- Charley Crockett - Self
- Tom Waits - Self
- Willie Nelson - Self
- Jason Isbell - Self
- Merle Haggard - Self
- Yola - Self
- Leon Bridges - Self
- Buddy Guy - Self
- Ed Sheeran - Self
- Ray Benson - Self
- Norah Jones - Self
- Mark Speer - Self
- Emmylou Harris - Self
- Steve Earle - Self
- Angel Olsen - Self
- Laura Lee - Self
- Jackson Browne - Self
- Brittany Howard - Self
- Miranda Lambert - Self
- Jack Ingram - Self
- Jade Bird - Self
- Olivia Rodrigo - Self
- Phoebe Bridgers - Self
- Terry Allen - Self
- Hal Ketchum - Self
- St. Vincent - Self
- Elizabeth Cotten - Self
- Susan Tedeschi - Self
- Ruthie Foster - Self
- Donald Johnson Jr. - Self
- Jorge Drexler - Self
- Margo Price - Self
- Molly Tuttle - Self
- Lil Yachty - Self
- Jenny Lewis - Self
- Jerry Douglas - Self
- Alanis Morissette - Self
- Noah Kahan - Self
- Tanya Tucker - Self
- Brittney Spencer - Self
- Pat Benatar - Self
- Neil Giraldo - Self
- Robert Glasper - Self
- Dave Grohl - Self
Tom Waits interpreta a Self en la serie.
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