- Aaron Tyler - Event Staff (uncredited)
- Candace B. Harris - Fast Food Cashier
- Keena Ferguson - Crystal
- Katt Williams - Uncle Willy
- Diane Sellers - Lorraine
- Grady Port - Alex
- Tiffany Denise Hobbs - Keisha
- Milton Saul - Strip Club Patron (uncredited)
- Rick Holmes - Craig Allen
- Abraham Clinkscales - Young Alfred
- Myles Truitt - Devin
- Alkoya Brunson - Young Earn
- Shariff Earp - Teen 3
- Christian Gabriel Anderson - Dexter
- Carl Andersson - Sam
- Aaron Heffernan - Demarco
- Samuel Blenkin - Wiley
- Hugh Coles - Socks
- Sean Gilder - Folk
- Justin Bartha - Marshall Johnson
- Conphidance - Owner
- Liam Neeson - Liam Neeson
- Alexander Skarsgård - Alexander Skarsgård
- Rachel Resheff - Kate
- Tyriq Withers - Aaron
- Adriyan Rae - Candice
- Lorenzo Yearby - Photographer
- Alan T. Coleman - Prince
- Jerome Beazer - Black Customer
- Renell Gibbs - Dude
- Nijah Brenea - Black Girl #1
- Teisha Speight - Elise
- Jamie Neumann - Gayle
- Christopher Farrar - Loquareeous
- Laura Dreyfuss - Amber
- Princess Elmore - Principal Miller
- Jenne Kang - Asian Social Worker
- Lauren Halperin - Counselor Grier
- Xosha Roquemore - Xosha
- Ronald Kalter - Teen 3
- Gail Bean - Nadine
- Kevin Samuels - Robert S. Lee
- Don Woods - James
- Jaxon McHan - Chad
- Triston Dye - Lionel
- Lisa Shatterly Boyd - Betsy
- Justin Hagan - Miles Warner
- Chet Hanks - Curtis
- Christina Bennett Lind - Bronwyn
- Armeen Acy - Guy 2
- Noel Arthur - Preacher
- Kamel Goffin - Steven
- Greg Wattkis - Cousin 1
- Diego Ward - Cousin 2
- Ashlyn Stallings - White Barista
- Dahlia Legault - Natalie
- Scarlett Blum - Katie
- Randall Taylor - Marshall's Boss
- Megan Hayes - Pink-Faced Woman
- Madison Hatfield - Paula
- Mary Emily Deal - Sobbing Woman
- Gus Allen - White Man in A Suit
- Tobias Segal - White
- Tobias Segal - E
- Melissa Youngblood - Sheniqua
- DJames Jones - Willy
- Tyrell Munn - Black
- Greta Glenn - Mrs. Granger
- Perris Drew - Male Friend
- Jillian Batherson - Mrs. Conner
- Ilana Kohanchi - Customer
- Sean Hankinson - Man In Glasses
- Sullivan Jones - Dr. Everette Tillman
- Myrthe Boersma - Female Security Officer
- Tim Olivier Somer - Male Security Officer
- Arthur Veen - Ambroos
- Matteo Simoni - Dirk
- Jonathan Huisman - Dutch Cop
- Ruben van der Meer - Driver
- Anniek Pheifer - Feena
- Jon Tarcy - Bell Boy
- Amalie Gissel Sparrebro - Hedy
- Elisa van Riessen - Death Doula
- Jessica Temple - Mom
- Patrick Kennedy - Will
- Daniel Fathers - Fernando
- Jasmine Leung - MK
- Darrell D'Silva - Bruce
- Daniel De Bourg - Yonathan
- Sheyi Cole - TJ
- Celeste Dodwell - Joanne
- Exie Booker - Lester
- Candi VandiZandi - Blonde
- Tyler Rainey - Black Jason
- Joan Reilly - Hotel Employee
- Jon Levine - Jewish Lawyer
- Regie Cashaw - Black Lawyer
- Kyle Potter - Orientation Leader
- Kevin Pocasangre - Cruz
- John Ramm - Guard
- Sokol Cahani - Security Guard Officer
- Lev Levermore - Paramedic
- Eddie Toll - Kid's Dad
- Gabriel Lo Giudice - Marcelo
- Kate Phillips - Wendy
- Richard Clifford - Bouchet
- Anita-Joy Uwajeh - Eniola
- Imogen Daines - Francesca
- Tamsin Topolski - Sharon
- Fisayo Akinade - Khalil
- Jan Le - Sam
- Selina Youngerman - Foreign Reporter
- Hannah Bourne - Jogger
- Reginald Huc - Concierge
- Gina Costigan - Woman
- Diane D. Carter - Second Older Woman
- Ava Grey - Lorraine
- Bram Klappe - Teen 1
- Hanne Arendzen - Woman
- Chaneil Kular - Cammy
- Aude des Pallieres - Flo
- George Wallace - Greg
- Da'Jon A. Porter - Flamboyant Kid
- Mark Law - Police Officer
- Aaron Goodson - Man
- Yoli Fuller - Emilio
- Soraya Garlenq - The Host
- Maël Besnard - Marcel
- Frédéric Deleersnyder - Busboy
- Florian Bresler - Second Waiter
- Lotfi Zarouel - Businessman
- Daniel Rashid - Benny
- Edon Rizvanolli - Taxi Driver
- Quinn Bozza - Engineer
- Moses Das - Engineer
- Tatiana Neva - Vendor
- Sinbad - Sinbad
- Joshua Gallup - ADR Voice Replacement (uncredited)
- Joshua Gallup - Additional Voices
- Ashley Lauren Thomas - Assistant
- Austin Elle Fisher - Lottie
- Darren Baba
- Hiro Murai
- Donald Glover
- Stefani Robinson
- Paul Simms
- Alexa L. Fogel
- Kathryn Zamora-Benson
- Jen Malone
Donald Glover hace el papel de Earnest 'Earn' Marks.
Liam Neeson interpreta a Liam Neeson en la serie.
Brian Tyree Henry interpreta a Alfred 'Paper Boi' Miles en la serie.
LaKeith Stanfield hace el papel de Darius Epps.
Zazie Beetz hace el papel de Vanessa 'Van' Keefer.
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