- Tanya Roberts - Midge Pinciotti
- Lisa Robin Kelly - Laurie Forman
- Tommy Chong - Leo
- Josh Meyers - Randy Pearson
- Justin Long - Andrew Davis
- Brooke Shields - Pamela Burkhart
- Alyson Hannigan - Suzy Simpson
- Robert Hays - Bud Hyde
- Shannon Elizabeth - Brooke
- Yvette Nicole Brown - Sergeant Davis
- Paul Butcher - Young Boy #2
- Samm Levine - Lance Crawford
- Steve Landesberg - Cal
- Jimmy Pardo - Stan
- Jack Riley - Old Man Shinsky
- Sam McMurray - Larry
- Don Knotts - Landlord
- Christopher Khayman Lee - Longhaired Guy
- Jack Osbourne - Andy
- Bruce Willis - Vic
- Lindsay Lohan - Danielle
- Barry Williams - Jeff
- Seth Green - Mitch MIller
- Suzanne Ford - Marsha Sullivan
- Dick Van Patten - Murph
- Jamie Kaler - Stew Bailey
- Billy Dee Williams - Pastor Dan
- Scott Holroyd - Mark
- Brandon Molale - Karate Instructor
- Jenna Fischer - Stacy Wanamaker
- Estella Warren - Raquel
- Liliana Mumy - Seven-Year-Old Donna
- Alex Nevil - Waiter #2
- Nancy Lenehan - Nina's Mom
- Roger Daltrey - Mr. Wilkinson
- Richard Kline - Ted
- Ted Nugent - Ted Nugent
- Kristina Wayborn - Honor
- Jamie Farr - Jamie Farr
- Nicholas Gonzalez - Thomas
- Cole Sprouse - Bobby
- Melinda Sward - Bachelorina #2
- Jim Beaver - Tony
- Katey Sagal - Edna Hyde
- Ernie Ladd - Manager
- Jim O'Doherty - Cop #2
- Brian Dunkleman - Waiter
- Brittany Daniel - Penny
- Connie Sawyer - Aunt Pearl
- Ernie Lively - Ted
- Neil Flynn - Bouncer
- Jessica Simpson - Annette
- Shirley Jones - Shirley Jones
- Carlos Alazraqui - Man
- Joe Flaherty - Bryan
- Jennifer Lyons - Pam Macy
- Eve Plumb - Mrs. Burkhart
- Marnette Patterson - Shelly
- Richard Karn - Theo
- Monty Hall - Monty Hall
- Bob Eubanks - Bob Eubanks
- Scott Whyte - David
- Marion Ross - Grandma Forman
- Mitch Hedberg - Frank
- Valerie Harper - Paula
- Keri Lynn Pratt - Tiffany
- Angelica Bridges - Model
- Natalia Cigliuti - Nice and Easy
- Francis Guinan - John Kelso
- Gloria Gaynor - Mrs. Clark
- Mo Gaffney - Joanne
- Rick Scarry - Dr. Browning
- Michael Milhoan - Coach Ferguson
- Betty White - Bea Sigurdson
- Erin Cardillo - Lisa
- Tommy Hinkley - Cop
- Stephen Tobolowsky - Professor
- Joey Zimmerman - Young Hyde
- Paul Anka - Paul Anka
- Jim Gaffigan - Roy
- Lindsay Sloane - Patty
- Christopher Masterson - Todd
- Chris Elliott - Mr. Bray
- Ron Pearson - Officer Ron
- Eliza Dushku - Sarah
- Mary Tyler Moore - Christine St. George
- Aria Wallace - Young Girl #2
- Eric Allan Kramer - Stuart Sutcliffe
- Jodi Carlisle - TV Announcer
- Morgan Fairchild - Carolyn
- Jack Salvatore, Jr. - Kid
- Christopher Knight - Josh
- Bob Morrisey - Doctor
- Christopher Darga - Transportation Rep
- Dan Castellaneta - Agent Armstrong
- Steffani Brass - Colette
- Dave Power - Big Marine
- Tom Poston - Burt Sigurdson
- Dylan Sprouse - Billy
- Mac Davis - St. Peter
- Jenilee Harrison - Carol
- Christopher Michael Moore - Art
- Sarah Lancaster - Melanie
- Joseph Gordon-Levitt - Buddy
- Tyce Diorio - Guy #2
- Allison Munn - Caroline
- Barbara Carrera - Barbara
- Markus Flanagan - Rob
- Curtis Armstrong - Barry Donovan
- Kevin Farley - Matthew Erdman
- Ken Kilpatrick - Wrestler #1
- Amanda Fuller - Tina Pinciotti
- Wayne Knight - Angel
- Shae D'Lyn - Rudolph (voice)
- Shanti Lowry - Dancer
- Jeff Austin - Mr. Brownberg
- John Ratzenberger - Glen
- Rod Roddy - Rod Roddy
- Dave Thomas - Chris
- Gary Owens - Announcer
- Gary Owens - Narrator (voice)
- Jackie Debatin - Sunshine
- Lyle Waggoner - Lyle Waggoner
- Bobcat Goldthwait - Eli
- Jennifer Alden - Natalie
- Christina Moore - Laurie Forman
- Caitlin Crosby - Chloe
- Rachel Bilson - Christy
- Adrienne Frantz - Kelly
- Tim Reid - William Barnett
- Jay Johnson - Chuck / Bob
- Earl Houston Bullock - Funeral Director
- Jim Turner - Therapist
- Melissa Joan Hart - Mary
- Jerry Lambert - Bank Rep
- Tom Kenny - Woofy
- Reid Scott - Ted
- Kala Savage - Teenage Paula
- Danny Bonaduce - Ricky
- Julie Claire - Customer #2
- Ileen Getz - Michelle
- Dave Florek - Guy
- Matt Battaglia - Dean
- Kevin McDonald - Dave
- Jeff Doucette - Dale
- Ashley Peldon - Young Kitty
- Linda Wallem - Jinx Mandell
- Linda Wallem - Nurse Phillips
- Deanna Wright - Sarah
- Constance Marie - Little Drummer Boy (voice)
- Leigh-Allyn Baker - Officer Debbie
- Andrea Bendewald - Ms. McGee
- Maud Adams - Holly
- Terry Wills - Craps Player
- Bob Clendenin - Earl
- Mitch Pileggi - Bull
- Shonda Farr - Rachel
- Suanne Spoke - Iris
- David Jeremiah - Game Show Announcer (voice)
- Jerry Hauck - Vet Rep
- Alice Cooper - Alice Cooper
- Gene LeBell - Referee
- Dwayne Johnson - Rocky Johnson
- China Chow - China
- Anne Stedman - Jill
- Amanda Noret - Bachelorina #1
- Ron Roggé - Robber
- Ron Roggé - Crazy Fan
- Marisa Brown - Bachelorina #3
- Wayne Pére - Randy
- John A. Maraffi - Masher
- Paul Kreppel - Mr. Burkhart
- Chris L. McKenna - Destroy
- Karri Bowman - Hostess
- Niklaus Lange - Giveback
- Mark Bramhall - Principal Pridwell
- Leslie David Baker - Janitor
- Michael James Reed - Cop #1
- Glen Beaudin - Jake
- Shannon Holt - Rebecca Erdman
- Drew Ebersole - Waiter
- Scott Haven - Cop
- Jenny Maguire - Kate
- Joe Medalis - Pastor
- Wendy Worthington - Customer #1
- Sarah Hawkins - Lisa
- Matt McKenzie - Patrolman #1
- Heidi Marshall - Jenny
- Megan Paul - Tracy
- Chip Heller - Cop #1
- Chris Hogan - Therapist #2
- Carolyn Hennesy - Sharon Singer
- Carolyn Hennesy - Patty Ryals
- Nick Bakay - Donna's Journal (voice)
- Nick Bakay - Santa (voice)
- Nick Bakay - Gus
- Steve Ireland - Dr. Ashley
- Grey DeLisle - Ms. Kaminsky
- Jade Gordon - Chrissy
- Pat Skipper - Marty
- Buckley Sampson - Charlene
- Kevin McClatchy - Man #1
- Jessica Meyerson - Charlotte
- Mary Pat Dowhy - Waitress
- Cindy Caponera - Amy
- Pat Finn - Frank
- Steve Larson - Judd
- Carol Mansell - Timmy's Mother
- Carol Mansell - Mary
- Josh Barker - Mike
- Amy Adams - Kat Peterson
- J. Robin Miller - Hot to Trot
- Jamie Anderson - Foxy Lady
- Al Leong - Ninja Warrior
- Paul Connor - Timmy
- Thomas Downey - Cop
- Charo - Charo
- Jordan Masterson - Paperboy
- Kavan Reece - Chip
- Lynsey Bartilson - Lynsey
- Lynsey Bartilson - Tammy Sue
- Oliver Macready - Guy
- Paul McKinney - Waiter
- Mindy Spence - Mindy
- Mindy Spence - Girl
- Doug Killen - Square Dance Caller
- Curtis Andersen - Teenage Boy
- Trent Gill - Nerd
- Corey Landis - Young Red
- Cheryl White - Mrs. Anderson
- Harry Campbell - The Dapper Four
- Shelby Grimm - The Dapper Four
- French Stewart - Daniel
- Terry Rhoads - Border Guard
- Terry Rhoads - Dr. Don
- Howard Hesseman - Max
- Reagan Gomez-Preston - Melissa
- Courtney Peldon - Katie
- Carnie Wilson - Carnie
- Sally Levi - Sally
- Laura Wernette - Joyce Ferguson
- Lisa Robins - Suzie
- Aimee J. Nelson - Connie
- Alicia Ziegler - Girl #1
- Natalie Farrey - Girl #2
- Erika Christensen - Stacy
- William Mesnik - Irate Customer
- Timothy Bottoms - Vice Principal Cole
- Pamela Sue Martin - Wizard
- Alice Frank - Alice
- Alice Frank - Leslie
- Cynthia Lamontagne - Rhonda
- Don Perry - Ed
- Don Perry - Older Man
- Timmy Deters - Jake
- Timmy Deters - Young Boy #1
- Laurel Garner - Ruth
- Matt Winston - Photographer
- Broc Benedict - Young Eric
- Ethan Peck - Young Kelso
- Alexandra Brandl - Young Jackie
- Victor Z. Isaac - Geeky Guy
- Sal Vassalo - Guy #1
- Becca Sweitzer - Girl #2
- Alexandra Lee - Kid #2
- Jeff Lewis - Guy in Line
- Jeanne Bates - Game Show Contestant (voice)
- Fred Willard - Charlie
- Jim Holmes - Olafsen Rep
- Tom Allard - Meat Rep
- Ashley Yegan - Bikini Clad Girl
- Garrett M. Brown - Nina's Dad
- Joanna Canton - Nina
- Caryn Greenhut - Julie
- Rozonda 'Chilli' Thomas - Hot Nurse
- Chancellor Miller - Little Boy
- Ashley Eckstein - Julie
- Ben Ziff - Guy
- Katie O'Rourke - INS Lady
- James Avery - Officer Kennedy
- Luke Wilson - Casey Kelso
- Tom Kiesche - Mr. Romine
- Saige Spinney - Receptionist
- Stacy Barnhisel - Rally Leader
- Nectar Rose - Kimberly
- Rachel Style - Girl #1
- Melissa Reneé Martin - Girl #2
- Jennifer Hamilton - Girl #1
- Jennifer Hamilton - Dancer #3
- Winston Story - Dennis
- Chip Chinery - Milkman
- Jamison Jones - Guy #1
- Todd Duffey - Guy #2
- Morgan Nagler - Ticket Girl
- Myra Turley - Woman
- Jordan Orr - Boy
- Jennifer Ann Massey - Janie
- Michael Cotter - Groom
- Marcia Ann Burrs - Stew's Mom
- Megalyn Echikunwoke - Angie Barnett
- Bret Harrison - Charlie
- Loretta Fox - Waitress
- Catherine Kresge - Kim
- Jack Lindine - Veteran
- Cody Nickell - Young Leo
- David Joyner - Jazz Musician
- Michael Maury - Army Buddy
- Richard V. Licata - Mr. Visotsky
- Jim Rash - Fenton
- Robert Kokol - Santa Claus
- Carol Ann Susi - Receptionist
- Isaac Hayes - Isaac Hayes
- Nicole Pantenburg - Dancer #1
- Sarah Christine Smith - Dancer #2
- Jud Tylor - Samantha
- Robert Clotworthy - Customer
- Tom Bosley - Dr. Hammond
- Lara Everly - Hilary
- Matt Cedeño - Indian
- Samantha Raddock - Linda
- Zach Selwyn - Rocker Guy
- Gavin MacLeod - Smitty
- Andrew Borba - Mr. Ortmeyer
- Colette Freedman - Mrs. Hollweg
- Tom Werner
- Greg Schaffer
- Caryn Mandabach
Stephen Tobolowsky interpreta a Professor en la serie.
Bruce Willis interpreta a Vic en la serie.
Wayne Knight hace el papel de Angel.
Dan Castellaneta interpreta a Agent Armstrong en la serie.
Billy Dee Williams interpreta a Pastor Dan en la serie.
Chris Elliott hace el papel de Mr. Bray.
Mila Kunis interpreta a Jackie Burkhart en la serie.
Danny Masterson interpreta a Steven Hyde en la serie.
Laura Prepon hace el papel de Donna Pinciotti.
Wilmer Valderrama interpreta a Fez en la serie.
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