- Charlie Sheen - Charlie Sheen (uncredited)
- Angus T. Jones - Angus T. Jones (uncredited)
- Ray Romano - 536 (Artie) (uncredited)
- Eugene Byrd - Eugene Byrd
- Frankie J. Allison - Frankie J. Allison
- Milton T.J. Taylor - Lamar
- Jack Doolan - Bobby Knox
- Ninja N. Devoe - Simone
- Toby Huss - Carl
- Izzy Diaz - Waiter Jerry
- Patrick Cage - Tarifa
- Arnetia Walker - Grandma Marion
- Michael McMillian - Stewie Malenkovich
- Jennifer Taylor - Crying Woman
- Marcus Folmar - Rehab Security Guard
- Kue Lawrence - Artie's Son
- Brittany Panzer - Rhiannon
- Gianna Bilby - Artie's Daughter
- Rob Corddry - Walt
- Wayne Knight - The Cowboy
- C.S. Lee - Jack Han
- Bob Clendenin - Gregory
- Christopher Bencomo - Lex
- Tara Holt - Brook
- Selina Kaye - Janelle
- Rebekah Graf - Walt's Girlfriend
- Steve Olson - Guy
- Rich Grosso - Director
- Matt Shea - Man
- Michael James Bell - Eugene
- Joe Hanna - 713 (O.C.) (voice)
- Brent Jennings - John 'Frank' Franklin
- Laraine Newman - Eileen
- Danny Woodburn - Petey
- Stephen Wesley Green - Paramedic
- Jeff Perry - Danny's Accountant
- Christopher Shyer - Patrick Ryan
- Jay Huguley - Dr. Hegland
- Beau Minniear - Zach Ryan
- Logan Riley - Danny's Mistress
- Gabriel Oliva - Waiter
- Chloe Zubiri - Female Client
- Roma Maffia - Nancy
- Stephen Guarino - Viggy
- Victor Turpin - Marco
- Bill Parks - Jeffrey
- Jeanette O'Connor - Phyllis
- Shelly Kurtz - Dino
- Leticia Bombardier - Juanita
- Natasha Hall - Yvette
- Ted Ferguson - Roger
- Earnestine Phillips - Delores
- Ronnie Clark - Homeless Person #1
- Madonna Cacciatore - Homeless Person #2
- Michael Franklin - Homeless Person #3
- Nelson Franklin - Kevin Miller
- DJ Qualls - Alan
- Ashley Rae Spillers - Mrs. Miller
- Joanna Sotomura - Gabby
- Frederick Dawson - Minister
- Pono Say - Jason
- Alex Lombard - Woman
- André Sogliuzzo - 703 (O.C.) (voice)
- Andy Tennant
- Nick Bakay
- Scott Printz
- Chuck Lorre
- Sebastian Maniscalco
- Judi Brown-Marmel
Eugene Byrd hace el papel de Eugene Byrd.
Wayne Knight interpreta a The Cowboy en la serie.
Sebastian Maniscalco interpreta a Danny Colavito en la serie.
Omar J. Dorsey hace el papel de Ray.
Jorge Garcia interpreta a Hector en la serie.
Andrea Anders hace el papel de Sandra Colavito.
Vanessa Ferlito hace el papel de Lorraine Colavito.
Maxim Swinton hace el papel de Anthony.
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