- Matt Walsh - Alan Waxman
- Jessica Makinson - Trudy
- Bobbie Prewitt - Lily
- Paul Rust - Jerry
- Jacob Hopkins - Connor
- Phillip Wilburn - Connor's Dad
- June Diane Raphael - Dr. Jill Leiter
- Brian Huskey - Nurse Howard
- Kevin Heffernan - Max Ricketts
- Chris Williams - Hubert Queel
- Adam Goldberg - Himself
- Christina Pickles - Sabrina French
- Fiona Gubelmann - Tinsley French
- Leigh Bush - Hot Girl
- Marisa Quinn - Animal Handler
- Crystal the Monkey - Dr. Rizzo
- Dominic Daniel - Vet Tech
- Peter Reinert - Hipster
- Lano Medina - Vet Tech
- Jeremiah Hu - Waiter
- Danielle Riffenburgh - Veterinarian
- Nick Jaine - Rod
- Kenny Ridwan - Young Yamamoto
- Kenji Nakamura - Yamamoto's Father
- Alice Dinnean - Bunraku Puppeteer
- Drew Massey - Bunraku Puppeteer
- Brandon Ford Green - Reporter
- Laura Spencer - Sarah
- Drew Tarver - Todd
- Jessica Leigh Gonzales - Vet Tech
- Chris Fogleman - Vet Candidate
- Jodie Mann - Nurse Judy
- Pat Kiernan - Self
- Annie Potts - Virginia Coleman
- Alan Brooks - Mr. Wesley
- Circus-Szalewski - Cab Driver
- Irene Roseen - Olivia
- Wyatt Oleff - Young George
- Jack Axelrod - Old Man
- Nick Youssef - Pet Owner
- Roni Akurati - Little Boy
- Steve Hely - Nurse McGarrity
- Mark Proksch - Gary
- Mark Berry - Judge
- Jonny Davila - Pet Owner
- Elena Varela - Lawyer
- Peter Vogt - Mr. Gruber
- Andrea Rosen - Ms. Mosely
- J.R. Ritcherson - Anthony Robinson
- Christopher Rich - Jack Jackson
- Vernee Watson-Johnson - Evelyn
- Lou Beatty Jr. - Don
- AlgeRita Wynn - Aunt Anna
- William Charles Mitchell - Uncle Walter
- Harrison White - Uncle Jake
- Peter A. Hulne - Trucker
- Zylan Brooks - Cousin Jasmine
- Ernest Harden Jr. - Uncle Nathan
- Brian Gatewood
- Alessandro Tanaka
- Anthony Russo
- Joe Russo
- Ravi Nandan
- Scot Armstrong
- Ludwig Göransson
Justin Kirk interpreta a George Coleman en la serie.
JoAnna Garcia interpreta a Dorothy Crane en la serie.
Tyler Labine interpreta a Doug Jackson en la serie.
Bobby Lee hace el papel de Robert Yamamoto.
Kym Whitley interpreta a Juanita en la serie.
Betsy Sodaro interpreta a Angela en la serie.
Capítulo disponible en las siguientes plataformas:
