- Adam Scott - Surgeon
- Gary Cole - Professor Everett Lamereau
- James Franco - Sgt. Eddie Pepper
- Sarah Chalke - Mrs. Parsons
- David Koechner - Commissioner Bigfish
- Keegan-Michael Key - Helmut FröntBüt
- Kerri Kenney - Laurie Partridge
- Scott MacArthur - Gordon Manhattan
- Danny Trejo - Himself
- Gene Simmons - Himself
- Ryan Hansen - Wilson Phillips
- Rhys Darby - Dr. Helm
- David Walton - Brad Wilson
- Danny Pudi - Garth Tweedner
- Paul Mabon - Cedric
- Heather Graham - Diane Duran
- Maya Rudolph - Jackie Wilder
- Colton Dunn - Denarius
- Michaela Watkins - Melanie Burke
- John Michael Higgins - Dr. Zaius
- John Michael Higgins - Randy / Dr. Zaius
- John Magaro - Snick
- Josh McDermitt - Cook
- Timothy Omundson - Dr. Duncan Farnsworth III
- Andrew Bachelor - Aaron McLaren
- Jean Smart - Carnie
- Rob Riggle - Calvin Sniglet
- Rob Riggle - Detective Zachary Fontaine
- Kyle Bornheimer - Scott
- Ed Helms - Dr. Clive Mister
- Chris Pine - Dr. Thomas Hornbein
- Graham Rogers - Eric
- Niecy Nash-Betts - Pandora
- Natalie Portman - Christina Craft
- Rob Huebel - Sperber Pennington
- Tyler Wiseman - Speed Racer
- Nick Cardiff - Telemetry Engineer
- Paul McKinney - Engines Engineer
- Ervin Ross - Orderly
- Cory Walls - Dave
- Peggy Lipton - Peggy Tribeca
- Mary McCormack - Abigail Liukin
- Scott Michael Morgan - Diet Coke Derek
- Matthew Cardarople - Neil
- Amy Smart - Stacy
- Jo Farkas - Old Lady Victim
- Pearce Joza - Kenny Atkins
- Aaron Carter - P.T. Cruiser
- Angel Laketa Moore - Nurse Jacqueline Margot
- Bobby Flay - Gary the Prisoner
- Michael Garza - Teen
- Jim Titus - Victor
- Bill Murray - Vic Deakins
- John Gemberling - Carl
- John Gemberling - Hipster Barista
- Cecily Strong - Samantha Stephens
- Aaron Lustig - Eric 'Short Game' Stehens
- Melinda Chilton - Sara in the Supermarket
- Marc Fajardo - Attendant
- Matt Miller - Starter
- Gabriela Flores - Paul's Daughter
- Judith Drake - Elderly Lady #1
- Laura Bell Bundy - Vivian Tribeca
- Duncan Bravo - Doctor
- Brett Gilbert - Nathan Prickley
- Dan Kinsella - Middle Aged Passenger
- Stacey Hinnen - Passenger #1
- Keiko Elizabeth - Passenger #3
- Heather Fox - Passenger #4
- Conor Duffy - Passenger #5
- Steven Shaw - Passenger #6
- Jonathan Cake - Nafan
- Brett Rice - Warden Harding
- Luis Fernandez-Gil - Bank Manager
- Chidi Ajufo - Chimney Sweep
- Nikea Gamby-Turner - Doris
- Josh Breeding - Ticket Taker
- Ryan Chase - Tough Guy
- Price Carson - Guard #1
- Teddy Lane Jr. - Gary the Guard
- Cuete Yeska - Delivery Man
- Jonathan Erickson Eisley - Cowboy
- Evan Boymel - Reporter #1
- Eileen Fogarty - Reporter #2
- Jackie Michele Johnson - Reporter #3
- William Walton - Charlie (Swat)
- Andreas Wigand - Screaming Cop Dave
- Michelle Dockery - Victoria Nova
- Randall Park - Dr. Moreau
- Chris Kirkpatrick - Chad
- Saul Rubinek - Pfoopa
- Joey McIntyre - Skylar
- Constance Zimmer - Detective Jessie Goldstein
- Kelly Rohrbach - Laura Ashley
- Ana Ortiz - Betty Crocker
- Lizzy Caplan - Deirdre
- Ernie Hudson - Pete Tribeca
- Eliza Coupe - Dr. Autumn Portugal
- Isla Fisher - Lana Bobanna
- Dove Cameron - Grace
- Jimmy Tatro - Paul Boneson
- Gillian Jacobs - Becky Bunker
- Anjelica Huston - Anna Summour
- Jim Rash - Philip Grammbbowski
- Rose Byrne - Norrah Newt
- Gina Torres - Gillian Kayhill
- Kathryn Hahn - Susan
- Carol Burnett - President Priscilla Filcox
- Jonney Ahmanson - Pilot
- Drew Fonteiro - Photographer
- Jamie VanDyke - Dead Model
- Mark Mullaney Jr. - Football Kicker
- Shira Scott Astrof - Susie
- Paul Zies - Kathy
- Matthew Glave - Joe Perry
- Nancy Carell - Mrs. Perry
- Lisa Kudrow - Monica Vivarquor
- Kerby Joe Grubb - Luge
- Joe Keyes - Contractor
- Rey Borge - Contractor
- Christine Bently - Pretty Young Woman
- David Haley - Plumber
- Francisco Ramos - Teaching Assistant
- Eric Garcetti - Mayor's Security
- Alfred Molina - Dr. Edelweiss (uncredited)
- Gillian Vigman - Jean Naté
- Will Greenberg - Dave the Sweeper
- Jeff Dunham - Fisher Price
- Nicole Byer - Holly
- Norma Michaels - Elderly Woman
- Luke Judy - 7-Year-Old Geils
- Hiram A. Murray - Gate Guard
- Katy Chase - Sales Rep
- Mike Holley - Security Guy
- Jenny Phagan - Stage Manager
- Jeff Marlow - John the Whisper Shouter
- Damian Cecere - Thomas Dolby
- Rob Mainord - Tour Guide
- Mark Chaet - Middle Aged Man
- Natisha Anderson - Tour Guide
- Christopher Carroll - Businessman
- Aryan Simhadri - Kid With Bullhorn
- David Douglas - Greg
- Rob Zabrecky - Dealer
- Aaron Ikeda - Mailman
- Stevens Gaston - Construction Worker
- Jon Hamm - McCormick
- Vicki Lewis - Anne Muffet
- Alison Rich - Detective Small
- Celia Finkelstein - Jane Dough
- Gary Ballard - Small Bald Man
- Lynette DuPree - Nurse Sharkey
- Nakia Burrise - Mrs. Quigley
- David L. King - Mr. Quigley
- Bruno Amato - Neighbor
- Harry Yi - Man
- Jonathan Palmer - Lawyer
- Gwen Van Dam - Kindly Old Woman
- Tzi Ma - Joseph Takagi
- Busy Philipps - Courtney Woodpatch-Newton
- Hira Ambrosino - Mrs. Maru
- Takuya Matsumoto - Fat Cat
- Kristen O'Meara - Computer Voice
- Gabrielle Sanalitro - Gloria
- Austen Jaye - Don
- Frank Noon - Gross Businessman
- Caitlin Kimball - Rookie Cop
- Kevin Pollak - Lieutenant Weinberg
- Jesse Rodriguez - Alberto Martínez
- Tiffany Panhilason - Stacy Galina
- Graham Outerbridge - Jeremy
- Kinyumba Mutakabbir - Mama Lukabubude
- Max E. Williams - Wilhelm
- Katie Gunderson - Gail
- Arianna Jaffier - Sandy
- Josh Meyers - Ned & Ted Doppelganger
- Anthony Giangrande - Frank
- Timothy E. Goodwin - Customer
- Edward James Gage - Security Guard
- Edward Hong - Matt
- Rachel Daigh - Detective Miles
- Matt Malloy - Bob Terrier
- Todd Robert Anderson - Peter Warren
- Jill E. Alexander - Rebecca Warren
- Terrence Beasor - Old Man
- David Salsa - Mark
- Derwin Jordan - Louis Potomac
- Irene Yee - Charlotte Potomac
- Edwin H. Bravo - Detective Steele
- Eriq La Salle - Dr. Brainerd
- Noah Wyle - Lewis Alcindor
- Todd Louiso - Fibonucci
- Melanie Hutsell - Nurse Barton
- Cheryl Francis Harrington - Nurse Lowboobs
- David Michie - Dr. Nate Stein
- Shannon Welles - Old Lady
- Christopher Corbin - Booth Owner
- Darrel Cherney - Booth Owner
- Joe Jonas - Detective Green
- Julie Dove - Fran Tabuto
- Freedom Bridgewater - Guard
- Jonathan Frakes - Commandant Van Zandt
- Daniel Stern - Dreyfuss
- Craig Gellis - Nathan Sterelli
- Abel Arias - Delivery Man
- Winston James Francis - Large Coastie
- Paul Bernard - Canadian
- Chasty Ballesteros - Young Woman
- Chasty Ballesteros - Zelda
- Wayne Wilderson - Sousa
- Blake Lee - Sebastian
- Patrick Hume - Janitor
- Jill Lover - Sobbing Woman
- Kurtis Bedford - Officer Stan
- Ed Begley Jr. - Bonnie
- Sean Poolman - UPS Guy
- Frank Birney - Old Man
- Daniel Nguyen - Dale
- John Eddins - Security
- David Grant Wright - Suity Guy
- Max Cutler - Man in Line
- Jessica St. Clair - Mrs. Claire Farnsworth
- Annie Mumolo - Beth Wiedner
- Juan Pablo Di Pace - Ricardo Vasquez
- Brian Michael Jones - Clerk
- Tom Billett - Warden Duffy
- Cassandra Relynn - Meter Maid
- Christian Calloway - Homeless Man
- Marcia Ann Burrs - School Teacher
- Gloria Calderón Kellett - Gretchen
- Antonio Aaron - SWAT Guy
- Greg Audino - SWAT Guy
- Myles Cranford - Dealer
- Markus Silbiger - Frat Boy
- Champagne Powell - Willie
- Lou Beatty Jr. - Swampy Latrine
- Bamm Ericsen - Bartender
- Nate Torrence - Kurt Piedmont
- Brad Leland - Arnold Waifer
- William Charles Mitchell - Judge Gruff
- Barry Livingston - Defense Lawyer
- Caroline Redekopp - Reporter
- Tom Riley - Dr. Frederick Wurst
- Connor Hines - Spencer
- Charan Prabhakar - Dr. Kottbulle
- Michael Vitiello - Stirelli
- Rachel Dratch - Masha Chekov
- Robert Pine - Larry Sniglet
- Michael D. Cohen - Louie
- Kelly Lester - Martha Sniglet
- Ulysses Lee - On Looker
- Iris Frank - On Looker
- Sheila Collins - Theatergoer
- C.J. Lindsey - Young Pete Tribeca
- Meredith Thomas - Carnie Tribeca
- Jack McBrayer - Wade
- Stephen Root - Mortimer Begoyle
- Cory Blevins - Mr. X / Gary Ecks
- David Weisenberg - Chairman
- Frank Pacheco - Executioner
- Drea Garcia - Mom
- Lucas Jaye - Kyle
- Scott Anthony Leet - Edward Stracciatelli
- Christopher Darga - Theodore Stracciatelli
- Scott Broderick - Guard
- Anthony Mingilino - Tommy Crocker
- Hymnson Chan - Busboy
- Ren Hanami - Fluga
- Eileen O'Connell - Lydia Curtis
- Scott Beehner - Fredrick Curtis
- Alan Brooks - Conrad Stone
- Kate Butler - Carol Stone
- Jonathan Ohye - Oliver Towne
- Dillon Paigen - Vomiting Cop
- Sabrina Revelle - Nurse Rached
- Billy Gardell - Officer Depot
- Eileen Barnett - Tanya Wiedner
- Nardeep Khurmi - Bartender
- Taran Killam - Pierre Cardin
- Vladimir Perez - Karl Vinson
- Dylan Mooney - Paramedic
- Dominique Domingo - Mother Giving Birth
- Begine White-Klein - Young Angie Tribeca
- Ben Lin - Elderly Asian Man
- Adam Karst - Claude Merlot
- Dustin Fasching - Charlie Clef
- Blaine Mizer - Peter
- Gerald Isaac Waters - Todd
- Lita Lopez - Ms. Smith
- Christopher Jefferson - Durphy
- Brandon Gibson - State Trooper
- Wayne Bastrup - State Trooper
- Joey Morgan - Ozzy
- Nik Dodani - CRISPIN_GLOVES0FF295
- Mark Weiler - Sergeant on Duty
- Romel de Silva - Richard
- Mapuana Makia - Nurse
- Keeshan Giles - Plumber
- Hash Patel - Man
- Jesus Ruiz - Waiter
- Bruce Katzman - Bobson Dugnutt
- Tony Cavalero - Timmy Rhebus
- Brian Adrian Koch - Fitz McSorley
- Katie O’Grady - Local Woman
- Ted Rooney - Bank Teller
- Jason Rouse - Willy Peter
- Eric Newsome - Dale Rugsby
- Betty Moyer - Darlene
- Carl Reiner - Glenn-Allen Mixon
- Jake Picking - Emerson Lake-Palmer
- Nikki Boyer - Sherry Netherlands
- Michael Hyland - Jeromy Gride
- Bill Lippincott - Mr. Kayhill
- Thomas Daniel Smith - Security Guard
- Sarah Cortez - Desk Clerk
- Ryan Windish - Bartender
- Romy Rosemont - Ellen Marmaduke
- Phil Morris - Samuel Hagar
- Harry Hamlin - Leonard Scholls
- Indira G. Wilson - Judge Sweeney
- Katherine Skelton - Dorothy Blatt
- Adrian Bustamante - Raul Chamgerlain
- Gabriel 'G-Rod' Rodriguez - Adrian Bustamante
- Chiquita Fuller - Factory Worker
- Andrea Hutchman - Co-Worker
- Dean Sharpe - Security Guard
- Alexis Frank Koczara - Stacey
- Christine Smith Shevchenko - Lisa
- Daniele Gaither - Gate Agent
- Lasaundra Gibson - Anchorwoman
- Ronnie Alvarez - Clerk
- Noah Applebaum - Hipster
- Jay Lee - Aide
- Joyce Greenleaf - Old Lady
- Roni Akurati - Donald
- James Brewster - Carpaccio MacGuffin
- Allison Dunbar - Julie Gaffney
- Alexander G. Eckert - Dennis the Menace
- Spencer Thomas - Life Guard
- Nick Bush - Jack Harbinson
- Ludwig Göransson
- Nathan Matthew David
Natalie Portman hace el papel de Christina Craft.
Jonathan Frakes interpreta a Commandant Van Zandt en la serie.
Carl Reiner interpreta a Glenn-Allen Mixon en la serie.
Saul Rubinek hace el papel de Pfoopa.
Alfred Molina hace el papel de Dr. Edelweiss (uncredited).
Todd Louiso interpreta a Fibonucci en la serie.
Mary McCormack hace el papel de Abigail Liukin.
Bill Murray hace el papel de Vic Deakins.
Rashida Jones interpreta a Angie Tribeca en la serie.
Bobby Cannavale interpreta a AJ Geils en la serie.
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