- Sarah Paulson - Cordelia Goode / Wilhemina Venable / Billie Dean Howard
- Sarah Paulson - Bette Tattler / Dot Tattler
- Sarah Paulson - Lana Winters
- Sarah Paulson - Sally McKenna / Billie Dean Howard
- Sarah Paulson - Ally Mayfair-Richards / Susan Atkins
- Sarah Paulson - Tuberculosis Karen / Mamie Eisenhower
- Sarah Paulson - Audrey Tindall / Lana Winters
- Alison Pill - Ivy Mayfair-Richards
- Joseph Fiennes - Monsignor Timothy Howard
- Michael Chiklis - Dell Toledo
- Cuba Gooding Jr. - Dominic Banks
- Kathy Bates - Delphine LaLaurie
- Kathy Bates - Ethel Darling
- Kathy Bates - Iris
- Kathy Bates - Agnes Mary Winstead
- Kathy Bates - Miriam Mead / Delphine LaLaurie
- Cheyenne Jackson - Will Drake
- Cheyenne Jackson - Dr. Vincent Anderson
- Cheyenne Jackson - John Henry Moore
- Cheyenne Jackson - Sidney Aaron James
- Angelica Ross - The Chemist / Theta
- Angelica Ross - Nurse Rita
- André Holland - Matt Miller
- Lizzie Brocheré - Grace Bertrand
- James Cromwell - Dr. Arthur Arden
- Matt Czuchry - Dexter Harding
- Jessica Lange - Constance Langdon
- Jessica Lange - Fiona Goode
- Jessica Lange - Elsa Mars
- Jessica Lange - Sister Jude Martin
- Angela Bassett - Desiree Dupree
- Angela Bassett - Ramona Royale
- Angela Bassett - Monet Tumissee
- Kim Kardashian - Siobhan Corbyn
- Annabelle Dexter-Jones - Sonia Shawcross / Adeline Harding
- Michaela Jaé Rodriguez - Nicolette
- Cara Delevingne - Ivy Ehrenreich
- Julie White - Io Preecher
- Matthew Morrison - Trevor Kirchner
- Gus Kenworthy - Chet Clancy
- Zach Villa - Richard Ramirez
- Audrey Ellis Fox - Betty Lou Jensen
- Maaz Ali - Kamal
- Evan Peters - Tate Langdon
- Evan Peters - Jimmy Darling
- Evan Peters - Kit Walker
- Evan Peters - Kyle Spencer
- Evan Peters - James Patrick March
- Evan Peters - Kai Anderson
- Evan Peters - Rory Manahan
- Evan Peters - Mr. Gallant/ Jeff Pfister / Tate Langdon / James Patrick March
- Evan Peters - Austin Sommers
- Emma Roberts - Madison Montgomery
- Emma Roberts - Maggie Esmerelda
- Emma Roberts - Anna Victoria Alcott
- Emma Roberts - Brooke Thompson
- Emma Roberts - Serena Belinda
- Denis O'Hare - Spalding
- Denis O'Hare - Stanley
- Denis O'Hare - Larry Harvey
- Denis O'Hare - Liz Taylor
- Denis O'Hare - William Van Henderson
- Denis O'Hare - Henry
- Denis O'Hare - Dr. Andrew Hill
- Denis O'Hare - Holden Vaughn
- Taissa Farmiga - Zoe Benson
- Taissa Farmiga - Violet Harmon
- Taissa Farmiga - Sophie Green
- Lily Rabe - Misty Day
- Lily Rabe - Sister Mary Eunice McKee
- Lily Rabe - Doris Gardner / Amelia Earhart
- Lily Rabe - Shelby Miller
- Lily Rabe - Lavinia Richter
- Lily Rabe - Aileen Wuornos
- Zachary Quinto - Dr. Oliver Thredson
- Zachary Quinto - Sam
- Zachary Quinto - Chad Warwick
- Wes Bentley - Det. John Lowe
- Wes Bentley - Dylan
- Wes Bentley - Edward Mordrake
- Patti LuPone - Kathy Pizazz
- Patti LuPone - Joan Ramsey
- Cody Fern - Michael Langdon
- Cody Fern - Xavier Plympton
- Cody Fern - Valiant Thor
- Billie Lourd - Winter Anderson / Linda Kasabian
- Billie Lourd - Hannah Wells
- Billie Lourd - Mallory
- Billie Lourd - Montana Duke
- Billie Lourd - Ashley
- Billie Lourd - Leslie 'Lark' Feldman
- Gabourey Sidibe - Queenie
- Gabourey Sidibe - Regina Ross
- Sandra Bernhard - Fran
- Sandra Bernhard - Hannah
- Dylan McDermott - Ben Harmon
- Dylan McDermott - Bruce
- Isaac Powell - Theo Graves
- Isaac Powell - Troy Lord
- Chloë Sevigny - Alex Lowe
- Chloë Sevigny - Shelley (archive footage)
- Lady Gaga - The Countess Elizabeth Johnson
- Lady Gaga - Scáthach
- Adina Porter - Dinah Stevens
- Adina Porter - Chief Burleson
- Adina Porter - Sally Freeman
- Leslie Grossman - Coco St. Pierre Vanderbilt
- Leslie Grossman - Ursrula Kahn / Calico
- Leslie Grossman - Barbara Read
- Leslie Grossman - Margaret Booth
- Leslie Grossman - Meadow Wilton
- Leslie Grossman - Ashleigh
- Leslie Grossman - Patricia Krenwinkel
- Leslie Grossman - Meadow Wilton (archive footage)
- Joshua Malina - Dr. Curran
- Jamie Harris - Franklin
- Rebecca Wisocky - Lorraine Harvey
- Christian Serratos - Becca
- April Grace - Nurse Naima
- Derek Richardson - Constance's Lawyer
- Shelby Young - Leah
- Eve Gordon - Dr. Hall
- Mageina Tovah - Bianca
- W. Earl Brown - Phil Critter
- Bianca Lawson - Abby
- Gregory Sporleder - Peter McCormick
- Missy Doty - Angela
- Michael Graziadei - Travis
- Eric Close - Hugo
- Andy Umberger - Dr. Day
- Eric Stonestreet - Derek
- Brando Eaton - Kyle Greenwell
- Ashley Rickards - Chloe Stapleton
- Azura Skye - Fiona
- Charles S. Dutton - Detective Granger
- Kate Mara - Hayden McClaine
- Alessandra Torresani - Steph Bogg
- Kathleen Rose Perkins - Chad's Therapist
- Malaya Rivera Drew - Detective Barrios
- Rosa Salazar - María
- David Anthony Higgins - Stan
- Grey Damon - Archie
- Ian Anthony Dale - David
- Arabella Field - Nora Benson
- Lance E. Nichols - Detective Sanchez
- Michelle Page - Young Myrtle
- Christine Ebersole - Anna-Lee Leighton
- Meg Chambers Steedle - Stillborn Mother
- Ameer Baraka - Bastien
- Matt Bomer - Donovan
- Matt Bomer - Andy
- Raeden Greer - Pauline LaLaurie
- John Aylward - Father Malachi
- Parker Croft - Devon
- John Lee Ames - Rudy
- David Chisum - Jim Brown
- Amy Farrington - Mrs. Reynolds
- Franka Potente - Anne Frank / Charlotte Brown
- Valorie Hubbard - Mrs. Hindsman
- Alexandra Breckenridge - Young Moira
- Alexandra Breckenridge - Kaylee
- Frances Conroy - Myrtle Snow
- Frances Conroy - Gloria Mott
- Frances Conroy - Belle Noir / Sarah Cunningham
- Frances Conroy - Angel of Death
- Frances Conroy - Bebe Babbitt
- Frances Conroy - Mama Polk
- Nikki Hahn - Jenny Reynolds
- Mark Margolis - Sam Goodman
- William Mapother - Driver
- Sean Patrick Thomas - Terry
- Tongayi Chirisa - Miles
- Debra Christofferson - Mrs. Stone
- Lara Harris - Rhonda Lancaster
- Chris McGarry - Mr. Lancaster
- Ian McShane - Leigh Emerson
- Brooke Smith - Dr. Gardner
- Ezra Buzzington - Sedated Patient
- Robin Bartlett - Cecily Pimbrooke
- Robin Bartlett - Dr. Miranda Camp
- Robin Bartlett - Pembroke
- Barbara Tarbuck - Mother Superior Claudia
- Jill Marie Jones - Pandora
- Matthew John Armstrong - Detective Byers
- Joel McKinnon Miller - Detective Connors
- Britne Oldford - Alma Walker
- Jack Conley - Officer Woods
- Camille Chen - April Mayfield
- Mark D. Espinoza - Jorge
- Joan Severance - Marian
- Andrew Leeds - Dr. Dunphy
- Riley Voelkel - Young Fiona
- Alexander Dreymon - Luke Ramsey
- Josh Hamilton - Hank Foxx
- Dana Gourrier - Chantal
- Stevie Nicks - Herself
- Michael Cristofer - Harrison Renard
- Neil Patrick Harris - Chester Creb
- Brennan Mejia - Gabriel Ramos
- Jon Bass - Milo
- Jacob Artist - Todd Connors
- Lee Hudson - Viking Hustler
- Josh Pence - Nick Harley
- Amir Talai - Mitch
- Ava Acres - Madeline
- Jessica Belkin - Vampire Girl
- Jessica Belkin - Wren
- Emma Bell - Tracy Logan
- Abby Donnelly - Peggy Cartwright
- Aimee Carrero - Picnic Girl
- Kimberly Dawn Guerrero - Ballgag
- Zack Ward - Roger
- Charles Melton - Mr. Wu
- Rafael de la Fuente - Picnic Guy
- Cameron Cowperthwaite - Speed Wagon
- Eugene Byrd - Greyson's Partner
- Walker Mintz - Son
- Adam Chambers - Paul Morrisey
- Joseph Will - Councilman Perry
- Ryan Alvarez - Maurice
- James Morosini - R.J.
- James Morosini - Bob Kinneman
- Chelsea Alden - Alissa
- Jim Calvert - Reporter #3
- Juli Cuccia - Mrs. St. Pierre Vanderbilt
- Dina Meyer - Nora Campbell
- Dennis Cockrum - Senator Herbert Jackson
- Rachel Roberts - Sharon Tate
- Sarah Yarkin - Riley
- Jeffrey Bowyer-Chapman - Andre Stevens
- Kingston Foster - Angelic Girl
- Naomi Campbell - Claudia Bankson
- Mare Winningham - Rita Gayheart
- Mare Winningham - Sally Keffler
- Colton Haynes - Detective Jack Samuels
- Christine Estabrook - Marcy
- Lena Dunham - Valerie Solanas
- Dermot Mulroney - Bob Thompson
- Ashley Santos - Emily
- Carlo Rota - Anton LaVey
- Charlene Amoia - Woman
- Lauren Stamile - Wife
- Caleb Foote - Pus Bucket
- Stephen Holland - Medical Examiner
- Mitch Pileggi - Art
- Dreama Walker - Real Rita
- Orla Brady - Dr. Karen Hopple
- John DeLuca - Rod
- David Bowe - Detective
- Vanessa Giselle - Cop
- Mark Daugherty - Chan
- Todd Stashwick - Blake
- Steven Culp - Brooke's Father
- Spencer Neville - Joseph Cavanaugh
- Zach Tinker - Sam
- Alexandra Fatovich - Reporter
- Christopher Murray - Sheriff
- Alex Livinalli - Julian Ramirez
- Laura Vallejo - Mercedes Ramirez
- Carlos Javier Rivera - Miguel
- Frederick Dawson - Minister
- Steve Kuzj - News Anchor
- Don Swayze - Roy
- Finn Wittrock - Dandy Mott
- Finn Wittrock - Tristan Duffy
- Finn Wittrock - Harry Gardner
- Finn Wittrock - Rudolph Valentino
- Finn Wittrock - Jether Polk
- Finn Wittrock - Bobby Richter
- Finn Wittrock - Jether Polk (archive footage)
- Billy Eichner - Harrison Wilton
- Billy Eichner - Mutt Nutter
- Billy Eichner - Tex Watson
- Billy Eichner - Brock
- Kaylee Bryant - Zombie Slut
- Tim Russ - David
- Richard Gunn - Chief Deputy
- Joseph Winford Warren - Bus Driver
- Doug Hurley - Forensic Tech
- Steven Hack - Coroner
- Brie Carter - Paramedic
- Cathy Marks - Dorothy
- Eric Staves - Dustin / Birdwatcher
- Yvonne Zima - Red
- John Carroll Lynch - Benjamin Richter
- John Carroll Lynch - Twisty the Clown
- John Carroll Lynch - John Wayne Gacy
- Tanya Clarke - Lorraine
- Nick Chinlund - Warden
- Kat Purgal - Younger Woman
- Vera R. Taylor - Older Woman
- Vico Ortiz - Rudy
- Connor Cain - Young Mr. Jingles
- Kat Solko - Helen
- Conor Donnally - Eddie
- Emma Meisel - Midge
- John Tague - Cop
- Stefanie Black - Stacey Phillips
- Victoria Hoffman - Mary Kay Lady
- Paul Rogan - Tour Manager Graham
- Misha Crosby - Limahl
- Piers Stubbs - Jez Strode
- Adam Zastrow - Roadie
- Jeremiah Folia - Steve Askew
- Jeremiah Folia - Steve Askew (uncredited)
- Lou Taylor Pucci - Jonas Shevoore
- DeRon Horton - Ray Powell
- Tara Karsian - Chef Bertie
- Naomi Grossman - Pepper
- Naomi Grossman - Samantha Crowe
- Sean Liang - Pete
- Harriet Sansom Harris - Madelyn
- BD Wong - Baldwin Pennypacker
- Billy Porter - Behold Chablis
- Kyle Allen - Timothy Campbell
- Brendan McCarthy - Detective Monroe
- David Atkinson - Butcher
- John Getz - Mr. St. Pierre Vanderbilt
- Melissa Barker - Wife (uncredited)
- Melissa Barker - Step Mom (uncredited)
- Martin Bats Bradford - George
- Donald Trump - Self (archive footage)
- Mike Pence - Self (archive footage)
- Hillary Clinton - Self (archive footage)
- Tim Kaine - Self (archive footage)
- Anna Carini - Loxi
- Heather Wynters - Daphne
- Collin Sutton - Man
- Kira Durbin - Wife
- John Dixon - Orderly #1
- Gloria Laino - The Mexican
- Marc Aden Gray - Dad
- Mark Engelhardt - Carl
- Joe Egender - Billy
- Chelsey Valentine - Missy Stone
- Devon Graye - Jed Potter
- Kristin Slaysman - Missy
- Bryan Rasmussen - Hank Stone
- Danielle Kennedy - Tudy
- Karen Constantine - Nun
- Erin Allin O'Reilly - Nurse Fuller
- Jennifer Holland - Nurse Blackwell
- Don Stark - Kit's Lawyer
- Lily Knight - Sister Felicity
- Victoria Reid - Asylum Inmate
- Anthony Ruivivar - Richard Ramirez / Miguel Ramos
- Anthony Ruivivar - Richard Ramirez
- Adam Levine - Leo Morrison (archive footage)
- Lori Mae Hernandez - Student
- Gary-7 - The Headbanger Inmate
- Cathy Fielding - Asylum Nun
- Nikki Christie - Hippie Babysitter
- Meg Wolf - Neo-Natal Nurse
- Paul Tei - Ted
- Rodney Rowland - Milo
- Evan Parke - Detective #1
- Thyme Lewis - Dante
- Sal Landi - Detective #2
- Chandler Kinney - Older Julia
- Brady Hender - Bully
- Nolan Gross - Young Johnny
- Callder Griffith - Older Thomas
- Cole Stratton - Worshipper #2
- Benjamin Papac - Rory
- Alan Brooks - Jack Krenski
- Christopher Carroll - Elder #1
- Marnie Crossen - Elder #2
- Rif Hutton - Elder #3
- Neal McDonough - Dwight 'Ike' Eisenhower
- Kaia Gerber - Kendall Carr
- Vince Foster - Henry Kissinger
- Eric Nenninger - Security
- Matt Nolan - G. Gordon Liddy
- Marty Dew - Bob Woodward
- Joe Pistone - Deputy
- Geoffrey Tozer - Piano Player
- Leslie Jordan - Courtney
- Leslie Jordan - Ashley Gilbert / Cricket Marlowe
- Leslie Jordan - Quentin
- Daeg Faerch - Joey
- Austin Woods - Hustler
- Blake Shields - Tony
- Rachel Finninger - Melanie
- Michael Andrew Baker - Chaka
- John Lacy - Mikey
- Ashlynn Ross - Marie Jeanne LaLaurie
- Ashlynn Ross - Myrna
- Jen Kober - Hostess
- Laurie Deziel - Pale Person #3
- V Nixie - Pale Person #5
- Kayla Blake - Doctor
- Jim Ortlieb - Ray Cunningham
- Eureka O'Hara - Crystal Decanter
- Deborah Geffner - JoAnna
- Gabriel F. Bellotti - Frank
- Robin Weigert - Mama Polk
- Robin Weigert - Martha
- Robin Weigert - Cynthia Potter
- Robin Weigert - Martha Edwards
- Jason Medwin - Bouncer
- Christine Lin - Woman in Costume
- Chad Michaels - Host
- Macaulay Culkin - Mickey
- Chris Caldovino - Colonel Jenson
- Samuel Hunt - Adam
- Maxwell Caulfield - Dwight's Friend
- Steven M. Gagnon - Air Force Officer
- Henry Joseph Samiri - Timmy Wycoff
- Emil Beheshti - Surgeon #2
- Sam Boxleitner - Army Major
- Mark Atteberry - Doctor
- Crystal Hughes - Waitress
- Jacqueline Pinol - Dr. Reyes
- Len Cordova - Steve Jobs
- Brett Edwards - Rattled Lieutenant
- Jeff L. Williams - Air Force General
- Michael Broderick - Navy Admiral
- Amelie Zazik - young Marilyn Monroe
- Emmett Hunter - Leader
- Rachel Hilson - Jamie Howard
- Craig Sheffer - Richard Nixon
- Christopher Stanley - Sherman Adams
- Mike Vogel - John F. Kennedy
- Bryce Johnson - Neil Armstrong
- Karl Makinen - Lyndon B. Johnson
- Briana Lane - Dr. Richards
- Jim Garrity - Air Force Officer
- Mark Mullaney Jr. - John
- Rebecca Dayan - Alana
- Rebecca Dayan - Maria Wycoff
- Ryan Kiera Armstrong - Alma Gardner
- Anthony Coons - Secret Service Agent #1
- Nico Greetham - Cal Cambon
- Paul David Story - Secret Service Agent #2
- Jon Jon Briones - Ariel Augustus
- Jon Jon Briones - Ariel Augustus (Archive Footage)
- David Shiflett - Old Dude Carny (uncredited)
- Nanrisa Lee - Marylin Chang
- Elaine Rivkin - Evelyn Lincoln
- Shane Carpenter - Gray
- John Sanders - Buzz Aldrin
- Mike Colter - David
- Lee Aaron Rosen - Captain Ross
- Jared Reinfeldt - Sully
- Quei Tann - Lita
- Clara McGregor - KK
- Jeff Hiller - Mr. Whitely
- John Bubniak - Freddy Moore
- Taylor Bloom - Stewart
- Danny Garcia - Chief Manney
- Kelsey Lea Jones - Tawny
- Brian Ray Norris - Detective Mulcahey
- Casey Thomas Brown - Hans Henkes
- Hale Appleman - Daniel Kanowicz
- Chris McGinn - Homeless Woman
- Sis - Dunaway
- Gideon Glick - Cameron Deitrich
- Sean-Michael Wilkinson - Young Detective
- Zach Meiser - Wiry Man
- Gabriel Awan - Officer
- Shirleyann Kaladjian - Coroner
- Candy Castillo - Dancer #2
- Atika Greene - Receptionist
- Thomas Michael Allen - Dr. Kornblatt
- Hannah Jane McMurray - Shachatth
- Ralph Adriel Johnson - Frankie
- Alexandre Bagot - Tom
- James Ciccone - Angelo DeMarco
- Henry G. Sanders - Willie
- Henry G. Sanders - Mr. Royale
- Danny Kornfeld - Billy
- Tyler Vincent - Club Goer #4
- Nathan Mattingly - Club Goer #5
- Dean Cestari - Sean
- Michael Austin Nicolo - Tipsy Gay Man
- David Robert - Bobby
- Tyler Johnson Ellis - Beautiful Young Man
- Chris Henry Coffey - Patrick's Father
- Ned Noyes - Priest
- Jamie Brewer - Marjorie
- Jamie Brewer - Hedda
- India Chappell - Theo's Assistant
- Brian David Tracy - Sam's Father
- Kevin Paul Woods - Wall Street Exec
- Colin Chapin - Patrick's Roommate
- Jane Dashow - Neighbor
- Nick Vergara - Cop
- Adrian Alvarado - Detective
- Layne Herrin - Handsome Stranger
- Tony Chiroldes - Doctor
- Barbara Christie - Patrick's Mother
- Jaren Anderson - Patrick's Brother
- Tony Bordonaro - Patrick Clone
- Thomas Barbusca - Jimmy
- Tom Virtue - Priest
- Tom Virtue - Reporter #1
- Tom Virtue - Principal Johnson
- Melanie Cruz - Teacher
- Katelyn Reed - Young Adelaide
- Riley Schmidt - Rubber Man
- Sarah Booth - Servant Girl
- Erik Adkins - M.P.
- Adam Gibson - M.P. #2
- Barry Anderson - Anesthesiologist
- Ari Barkan - Paparazzi #1
- Andy Cohen - Andy Cohen
- Taylor Richardson - Babette Eno
- Dominic Burgess - Hamish Moss
- Tavi Gevinson - Cora
- Tavi Gevinson - Cora (voice)
- Tavi Gevinson - Receptionist
- Tommy Nohilly - Detective #1
- Ryan Spahn - Derek
- Carmen Borla - Yoga Teacher
- Brady Hales - Paparazzo
- Chhoyang Cheshatsang - Male P.A.
- Tony von Halle - Paramedic
- Tim Venable - Dr. Sapirstein
- Debra Monk - Virginia Harding
- Sophie von Haselberg - Ashleigh
- Blair Sams - Midwife
- Daniella Alma - Head Lady-in-Waiting
- David Ilku - Karl Lagerfeld
- Pascal Yen-Pfister - Yves Saint Laurent
- Jade Cayne - Siobhan's Assistant
- Harry Bouvy - Luther Feldman
- Taylor Schilling - Golden Globes Presenter (uncredited)
- Ben Woolf - Meep
- Ben Woolf - Infantata
- Shaun Ross - Albino #3
- Shaun Ross - Albino #2
- Chrissy Metz - Ima 'Barbara' Wiggles
- Celia Weston - Lillian Hemmings
- Danny Huston - Massimo Dolcefino
- Malcolm-Jamal Warner - Angus T. Jefferson
- Angela Sarafyan - Alice
- John L. Armijo - Gardener
- Dot-Marie Jones - May
- Dot-Marie Jones - Trooper Jan Remy
- David Burtka - Michael Beck
- Jyoti Amge - Ma Petite
- Christopher Neiman - Salty
- Patti LaBelle - Dora Ross
- Lee Tergesen - Vince
- Cynthia LeBlanc - Townie
- Blanca Araceli - Widow
- Blanca Araceli - Pilar
- Tony Bentley - Mr. Hainey
- Elton LeBlanc - Townie
- Matthew Glave - Larry
- Ross Britz - Uniformed Officer
- Vernel Bagneris - Dancin' Joe
- Lyle Brocato - George Mills
- J.D. Evermore - Rakes
- Judd Lormand - Doyle
- James DuMont - Foster
- Al Vicente - Mr.Russell
- Major Dodson - Corey Bachman
- Benton Jennings - Butler Graves
- Benton Jennings - Butler
- Candi Brooks - Southern Belle
- Dodie Brown - Mary
- Lucy Faust - Joanne
- Amber Gaiennie - Elaine
- John Cromwell - Young Arden
- Christopher Berry - Leo
- Richard Holden - Henry Gable
- Robert Walker Branchaud - Erickson
- Sharon Landry - Brenda
- Laura Flannery - Jane
- Ann McKenzie - Eudora Tattler
- Dalton E. Gray - Mike
- Neal Kodinsky - Bartender
- Lara Grice - Avon Lady
- John Henry - Carney
- Ruby Lou Smith - Judy Manners
- John Wilmot - Father Kelly
- Skyler Samuels - Bonnie Lipton
- Thomas Francis Murphy - Mr Haddonfield
- John Neisler - Dr Hudson
- Ramona Tyler - Mildred Bachman
- Dane Rhodes - Det. Bunch
- Jerry Leggio - Dr Bonham
- Edward Gelhaus - Younger Dell
- Mattie Liptak - Tommy
- Mädchen Amick - Mrs. Ellison
- Jack Fisher - Albert
- Kevin Fry-Bowers - Martin Gamboa
- Tiffany Brouwer - Janice
- Barbara Lee Bragg - Sheik's Mother
- Mat Fraser - Paul
- Richard T. Jones - Det. Andy Hahn
- Lucius Baybak - Sheik
- Christopher Foley - Lex
- Garrett Nichols - Leonard Landecker
- Eden Malyn - Miranda
- Shree Crooks - Scarlett Lowe
- Jessica Lu - Babe
- Helena Mattsson - Agnetha
- Adam Lieberman - Detective Colquitt
- David Barrera - Dr Kaplan
- Alexandra Daddario - Natacha Rambova
- Lyn Alicia Henderson - Detective Barker
- Lindsay Pulsipher - Tina Black
- Alanna Ubach - Jo
- Jo Farkas - Phyllis Landecker
- Nico Evers-Swindell - Craig
- Colby French - Officer
- Larry Cedar - Auctioneer
- Grady Lee Richmond - Ishmael Polk
- Orson Chaplin - Cain Polk
- John Farzad Strong - Doctor
- Stephan Goldbach - Serial Rapist
- Luke LaGraff - Scalped Man
- Marti Matulis - Piggy Man
- Kristen Rakes - Nurse Bridget
- Charles Malik Whitfield - Mason Harris
- Jonathan Pessin - Bank Rep
- Irene Roseen - Margaret
- Irene Roseen - Molly
- Saniyya Sidney - Flora Harris
- Michael McCusker - Officer
- Tim Scanlon - Dead Parent #2
- Tim Scanlon - Bailiff
- Gigi Bermingham - Lawyer
- Jamieson Deacy - Creepy School Kid
- Monnae Michaell - Judge
- John Pyper-Ferguson - Mr. Cage
- Jacquie Barnbrook - Social Worker
- Joe Calarco - Henry Dorrell
- Celeste Den - FBI Agent
- Connor Rosen - Feral Boy #2
- Molly Baker - Karen
- Miya Cech - Amy Chen
- Hahn Cho - Gary Chen
- Nick George - Fort Guard
- Megan Truong - Grace Chen
- Becky Wu - Daisy Chen
- Kevin Bielinski - Prison Guard
- Henderson Wade - Guinness
- Doris Kearns Goodwin - Doris Kearns Goodwin
- David A. Kimball - Art Auctioneer
- Shannon Lucio - Diana Cross
- William R. Moses - Frank
- John Prosky - Production Legal Team
- Chaz Bono - Gary K. Longstreet
- Chaz Bono - Lot Polk
- Chaz Bono - Brian Wells
- Joe Alvarez - Mason’s Corpse
- Kimberly Bailey - OSHA Rep
- Areana Cirina - Nurse Bridget’s Ghost
- Dana Daurey - Female Executive
- Jenna Doolittle - Nurse Miranda’s Ghost
- Julie Rei Goldstein - Tall Amazonian Woman
- Gary Kraus - Mack
- Andy Kreiss - Bald Executive
- Ric Sarabia - Crazed Man
- Michele Santopietro - Sultry Woman (archive footage)
- Susan James Berger - Real Butcher
- Frank Collison - Real Ishmael Polk
- Elliott Ehlers - Real Edward Mott
- Frederick Koehler - Real Lot Polk
- Jamie Martz - Bodycam Officer
- Michael Whaley - Investigating Detective
- Alexis Jacknow - Engle
- Billy Snow - Uber Driver / Rhett Snow
- Jesse La Flair - Ambrose
- Marlon Correa - Officer Costa
- Christopher Allen - Officer Benton
- Simone Baker - Flora Harris
- Brian Howe - Mark Phillips
- Danielle Macdonald - Bristol Windows
- Julie Claire - Stephanie Holder
- Joe Spellman - Dave Elder
- Thea Andrews - Pundit #1
- Audrey Casson - Priscilla
- Christine Devine - Anchor #1
- Kirk Hawkins - Anchor #2
- Kevin Foster - Sheriff
- Tony Forsmark - News Cameraman
- Juliana Canfield - Talia Thompson
- Juliana Canfield - Talia Baldwin
- Juliana Canfield - Talia Donovan
- Juliana Canfield - Talia
- Diane Mizota - Reporter #2
- Tai Bennett - Reporter #3
- Cassandra Relynn - FBI Negotiator
- Jessica Pressley - Flora Harris (TV)
- Napoleon Tavale - Juror #2
- Betsy Baker - Juror #5
- Melody Peng - Audience Member
- Savannah Liles - Real Priscilla
- Skyler Shelley - Weeping Fan Girl
- Trixie Mattel - Self
- Kamilla Alnes - Vendela
- Chasty Ballesteros - Young Woman
- Grace Gummer - Penny
- Grace Gummer - Margaret Alcott
- Mark Gantt - EMT Worker
- Andy Martinez, Jr. - Officer Romero
- Liana Mendoza - Cop
- Maz Siam - Cabbie
- Kenley Smyth - Young Scarlett
- Jean-Christophe Febbrari - Concierge
- Punnavith Koy - Carnival Goer
- Alexander Ward - Addiction Demon / Mattress Man
- Nick Baker - 1930’s Cop
- Bradley Fisher - Young Man (1930's)
- Ron Roggé - Barker
- JB Tadena - Bomb Tech
- Sean Laguna - Young Donovan (Deleted Scene)
- Tanya Flynn - Fashion Show Background
- Drew Kenney - Runway Model
- Sarah Allyn Bauer - Terrified Girl (1930's)
- Roxana Brusso - Dr. Kohan
- Tyler Bryan - Colin Marshall
- Tyler Bryan - Man in Tux
- Zay Harding - Holes
- Jorge-Luis Pallo - Pedro Morales
- Cooper Dodson - Oz Mayfair-Richards
- Bo Roberts - Kooks
- Stephen Simon - Officer
- Arlene Barshinger - Election Party House Guest
- Tim Kang - Tom Chang
- Sadiqua Bynum - Suspenders
- Laura Allen - Rosie
- Ron Melendez - Mark
- Seth Coltan - Nude Man
- Derek Johnson - Officer
- Michelle Jubilee Gonzalez - Mara
- T.J. Hoban - Vincenzo 'Vinny' Ravoli
- Bill Parks - Cole
- Annette Azcuy - Soccer Mom
- Yeniffer Behrens - Volunteer
- Matthew Bridges - Young Hipster
- Jasper Cole - Shaggy Thug
- Michael Delgado - Skeevy Thug
- Ashlie Atkinson - Susan
- Ashlie Atkinson - Anna's Superfan
- Ashlie Atkinson - Fan
- Heather Olt - Shirley
- T.J. Alvarado - Stoner Dude
- J. Grant Albrecht - Scott Anderson
- Wylie Small - Julie Anderson
- Chris Guzzi - The Gimp
- Exie Booker - Pundit #2
- Exie Booker - Commander
- Chip Chinery - Leland Candoli
- Rusnico Canonigo Jr. - Noah
- Jorga Caye - Rally Goer
- Steve Bannos - Policeman
- Lyla Porter-Follows - Young Bebe Babbitt
- Marqus Bobesich - Clerk
- Erin Mulvey - Cecelia Shepherd
- Jeff Rector - Male Anchor
- Tyler Cook - Lumberjack (archive footage)
- Tyler Cook - Lumberjack
- Ben Rosenbaum - Cop
- Miguel Sagaz - Bruce
- Shondalia White - Martha
- Michael Lanahan - Taylor Mead
- Jess Allen - Sandstorm
- Jess Allen - Cracker #1
- Brandon Molale - 1969 Institution Guard
- Brandon Van Vliet - Inmate
- Rick Springfield - Pastor Charles
- Sasha Boggs - Woman
- Derek Chariton - Man
- Mario Diaz - Gay Man
- Dustin Christenson - Tripod
- Kaiwi Lyman - Gutterball
- Denver Smith - Male Heaven's Gate Member
- Noelle Messier - Female Heaven's Gate Member
- Martin Mathieu - Councilman Moyer
- Kevyn Bashore - Citizen / Lawyer
- Kate Boyer - Angel
- Adam Burnette - Cult Member
- Suzanne LaChasse - Angel
- Damion Le Vias - Jonestown Guard
- Frank Lui Geo - Ritualist
- Tisha French - Female Attendant
- Frank Gallegos - Cameraman
- Annie Gonzalez - Demonstrator
- Miraj Grbić - Wojciech Frykowski
- Charlie Farrell - Jay Sebring
- Alexandra Marian Hensley - Abigail Folger
- Zachary Conneen - Steven Parent
- Riley Rose Critchlow - Woman
- Monique Lea-Gall - Bailey
- Tom Frank - Manson
- Adam Dunnells - Freddy
- Matt Lasky - Jimbo
- Courtney Friel - Female Anchor
- Monique Blanchard - Hostess
- Derek Burton Morris - New Proud Boy
- Liz Jenkins - Gloria
- Annie Ilonzeh - Erika
- Ian Bamberg - Trevor
- Brian Oerly - Clifton
- Brian Oerly - Cracker #2
- David Mattey - Cracker #3
- Jason Scott Jenkins - Prophet Moses
- Baxter Humby - Bleeding Man
- Dalia Phillips - ER Doctor
- Anton Starkman - Max Ellison
- Louise Van Veenendaal - Heroin Girl
- David Naughton - Mr. Samuels
- Dieterich Gray - Cop (1927)
- Cyd Strittmatter - Woman in Bed
- Brittany Panzer - Halloween Girl
- Harry Hains - Boy
- Mouzam Makkar - Nurse Leena
- Robert Knepper - Lieutenant
- Kristen Ariza - Mrs. Pritchard
- Bill Coelius - Franklin
- Yolanda Snowball - ICU Nurse
- Annie Savage - Patty
- Granville Ames - Detective
- Laura Black - Tracy
- Summer H. Howell - Policewoman
- Summer H. Howell - Girl
- Robert Lewis Stephenson - Madeline’s Father
- Nicole Tompkins - Older Scarlett (17)
- Drew Snyder - Televangelist
- Jill E. Alexander - Nurse
- Veronica Mannion - Fan Girl #1
- Shannon Lorance - Fan Girl #3
- Lars Slind - Vince
- Jimmy Taylor - Gareth
- Henrik Rutgersson - Murnau
- Catherine Fetsco - Carpathian #3
- Courtney Cooper - Carpathian #6
- Benjamin Franczuszki - Carpathian #5
- Travis Hammer - Laborer
- Tom Oakley - Jesse
- Bruno Oliver - Foreman
- Blake Webb - Guard
- Monica Hewes - Gibby
- Clayton Farris - Assistant Director
- Helen Eigenberg - Nurse
- Steven T. Bartlett - Minister
- Michael Laren - Hotel Hobo
- Kurt Meyer - Officer
- Stevie Lee - Evil Dwarf #2
- Reed Birney - Dexter Harding
- Carter Hudson - Ned Alcott
- David Healy - Doctor
- Janel Koloski - Cristin
- Katie Kuang - Salesperson
- Cricket Brown - Sonia / Adeline Double
- Gaby Slape - Mia Farrow
- Tom O'Keefe - Frank Sinatra
- Ben Beckley - DP
- Janell Sexton - Nurse
- Mallory Portnoy - Peppy Nurse
- Lauren Hines - Vendor #1
- Nhumi Threadgill - Vendor #2
- Scarlett Fernandez - Angela
- Josh Plasse - Waiter
- Ryan Murphy
- Brad Falchuk
Chloë Sevigny interpreta a Shelley (archive footage) en la serie.
Lily Rabe interpreta a Doris Gardner (Red Tide) / Amelia Earhart (Death Valley) en la serie.
Harriet Sansom Harris hace el papel de Madelyn.
Craig Sheffer interpreta a Richard Nixon en la serie.
John Carroll Lynch interpreta a John Wayne Gacy en la serie.
Jessica Lange hace el papel de Elsa Mars.
Sandra Bernhard hace el papel de Fran.
Frances Conroy interpreta a Belle Noir (Red Tide) en la serie.
Dina Meyer interpreta a Nora Campbell en la serie.
Eugene Byrd interpreta a Greyson's Partner en la serie.
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