- Chris Obi - Mr. Jacquel / Anubis, the Egyptian god of the dead.
- Chris Obi - Mr. Jacquel/Anubis
- Gillian Anderson - Goddess Media
- Gillian Anderson - Media
- Cloris Leachman - Zorya Vechernyaya, the Evening Star
- Cloris Leachman - Zorya Vechernyaya
- Peter Stormare - Czernobog, Slavic god of darkness, death, and evil
- Peter Stormare - Czernobog
- Jacqueline Antaramian - Mrs. Fadil
- Jonathan Tucker - 'Low Key' Lyesmith
- Betty Gilpin - Audrey
- Beth Grant - Jack
- Joel Murray - Paunch
- Dane Cook - Robbie
- Keller Viaene - Young Essie Macgowan
- Jake Manley - Bartholomew
- Laura Bell Bundy - Columbia
- Tracie Thoms - Buffer
- Ron Lea - Cambro
- Matthew Gouveia - Cassius
- Chris Handfield - Clay
- Corbin Bernsen - Vulcan
- David Labiosa - Tattooed Man
- Ernesto Reyes - Mexican Jesus
- Tim Progosh - Richard Miller
- Orlando Jones - Mr. Nancy
- Jeremy Davies - Jesus Prime
- Kristin Chenoweth - Easter
- Parveen Kaur - Young Persian Woman
- Jerald Bezener - Handsome American Man
- Marni Van Dyk - Stewardess
- Mousa Kraish - The Jinn
- Dean Winters - Mr. Town
- Christian Lloyd - Argus
- William Sanderson - The Bookkeeper
- Mustafa Shakir - Baron Samedi
- Glynn Turman - Reverend Hutchins
- Mouna Traoré - Ruby Goodchild
- Derek Theler - Donar
- Clark Middleton - Sindri
- Niamh Carolan - Fiona
- Sakina Jaffrey - Mama-Ji
- Clare McConnell - Eorann
- Eric Peterson - The Caretaker
- Kahyun Kim - New Media
- Oluniké Adeliyi - Shadow's Mom
- Scott Hilton - Farmer
- Sash Striga - Show Girl #8
- Hani Furstenberg - Maman Brigitte
- Luc Trottier - Viral
- Neil Girvan - Mr. Road
- Dave Lapsley - State Trooper
- Joan Gregson - Helen
- Zarrin Darnell-Martin - Sadie
- Anwen O'Driscoll - Sophie
- Donald Burda - Factory Supervisor
- Graham Greene - Whiskey Jack
- Graham Greene - Whiskey Jack (voice)
- Rick Amsbury - Vengard Velten
- Glenn Edward Gyorffy - Band Member #2
- Amanda Barker - Bus Clerk
- Cassandra Potenza - Death Metal Ballerina #4
- Marilyn Manson - Johan Wengren
- Marilyn Manson - Johan
- Erika Kaar - Zorya Polunochnaya
- Martha Kelly - Zorya Utrennyaya
- Yan Lecomte - French Trader
- Bas Reitsma - German Trader
- Dan Willmott - Lou Hennings
- Andi Hubick - Alison McGovern
- Gil Bellows - Bill Sanders
- Gil Bellows - William Huntington Sanders
- Jackson Reid - Nervous Boy
- Samantha Brown - Nervous Boy's Mother
- Ian Deakin - Middle Aged Andy
- Flint Eagle - Tribal Elder
- Sochi Fried - Usherette
- Sarah McVie - Agatha
- Dominique Jackson - Ms. World
- Denis O'Hare - Tyr
- Denis O'Hare - Tyr / Tyrell
- Ian Matthews - All-Seven
- Andrew Gillies - Woody
- Sean Bell - Mark
- Martin Roach - Gilbert
- Deb Filler - Cocktail Waitress
- Lela Loren - Marguerite Olsen
- Lela Loren - Marguerite Olsen / Property Manager
- Blythe Danner - Demeter / Caroline Wells
- Blythe Danner - Demeter
- Jeremy Crutchley - Maximillian
- Spencer MacPherson - Derek
- Nabeel El Khafif - Hank
- Sebastian Spence - Larry Hutchinson
- Robert Cormier - Winston
- Danijel Mandic - Aaron
- Gina Phillips - Megan Gunther
- Dan Darin Zanco - Laundromat Owner
- Eric Woolfe - Hustler
- Karen Glave - Aye
- Karen Glave - Aya
- Jacob Soley - Boy
- Troy Amos-Ross - Bare Knuckle Fighter
- Tom York - Colonial Wednesday
- Devery Jacobs - Sam Blackcrow
- Aaron Poole - Colonial Tyr
- Gwynne Phillips - Colonial Demeter
- Jane Spidell - Mabel
- Demore Barnes - Mr. Ibis
- Herizen F. Guardiola - Oshun
- Mercedes Morris - Meme
- David Reale - Dr. Fapp
- Danny Trejo - Mr. World
- Sharon Hope - Eugenia
- Iwan Rheon - Doyle
- Julia Sweeney - Ann-Marie Hinzelmann
- Eric Johnson - Chad Mulligan
- Bea Santos - Trending
- Bridget Ogundipe - Yemoja
- Stephannie Hawkins - Priestess Io
- Conphidance - Okoye
- Wale - Chango
- John Tench - Viking Leader
- Julian Richings - Iktomi
- Gianpaolo Venuta - Man on Bus (uncredited)
- Adam Kane
- Jon Amiel
- Metin Hüseyin
- Christopher J. Byrne
- Rachel Talalay
- Deborah Chow
- Maria Melnik
- Laura Pusey
- Tyler Dinucci
- Heather Bellson
- Aditi Brennan Kapil
- Adria Lang
- David Graziano
- Padraic McKinley
- Ian McShane
- David Coatsworth
- Orlando Jones
- Neil Gaiman
- Kevin Banks
- Danny Bensi
- Saunder Jurriaans
Julian Richings interpreta a Iktomi en la serie.
Crispin Glover interpreta a Mr. World en la serie.
Jeremy Davies interpreta a Jesus Prime en la serie.
Peter Stormare hace el papel de Czernobog.
Ian McShane interpreta a Mr. Wednesday / God Odin en la serie.
William Sanderson interpreta a The Bookkeeper en la serie.
Ricky Whittle interpreta a Shadow Moon en la serie.
Emily Browning interpreta a Laura Moon en la serie.
Yetide Badaki hace el papel de Bilquis.
Bruce Langley hace el papel de Technical Boy.
Capítulo disponible en las siguientes plataformas:
