- F. Murray Abraham - Narrator
- Liev Schreiber - Narrator (voice)
- Linda Hunt - Narrator (voice)
- Jason Robards - Narrator (voice)
- Mary McDonnell - Narrator (voice)
- Donald Sutherland - Narrator (voice)
- Peter Coyote - Narrator (voice)
- Alfre Woodard - Narrator (voice)
- Dion Graham - Narrator (voice)
- Brian Dennehy - Aaron Burr (voice)
- Joe Morton - Narrator (voice)
- Mandy Patinkin - Narrator (voice)
- Randy Quaid - Narrator (voice)
- René Auberjonois - Woodrow Wilson (voice)
- René Auberjonois - Alexander Hamilton (voice)
- Judith Light - Narrator (voice)
- Tom Hanks - Narrator (voice)
- Carl Lumbly - Narrator (voice)
- Marion Ross - Edith Bolling-Galt (voice)
- Cherry Jones - Narrator (voice)
- Keith Carradine - Narrator (voice)
- Hector Elizondo - Narrator (voice)
- Blair Brown - Narrator (voice)
- Blair Brown - Ellen Wilson (voice)
- Morgan Freeman - Narrator (voice)
- Scott Glenn - Narrator (voice)
- Courtney B. Vance - Narrator (voice)
- Laura Linney - Narrator (voice)
- Robert Duvall - Narrator (voice)
- Glenn Close - Narrator (voice)
- Charles Kuralt - Narrator (voice)
- Irv Drasnin - Narrator (voice)
- Hume Cronyn - Narrator (voice)
- Ruby Dee - Narrator (voice)
- Robert Redford - Narrator (voice)
- Stacy Keach - Narrator (voice)
- Philip Bosco - Narrator (voice)
- Joe Mantegna - Narrator (voice)
- David McCullough - Narrator (voice)
- David McCullough - Self
- Hal Linden - Narrator (voice)
- James Avery - Charles Hamilton Houston (voice)
- James Avery - Narrator (voice)
- Ellen Burstyn - Narrator (voice)
- Susan Sarandon - Narrator (voice)
- Russell Baker - Narrator (voice)
- William Stanley Merwin - Narrator (voice)
- Hal Holbrook - Narrator (voice)
- Eric Sevareid - Himself
- Eric Sevareid - Narrator (voice)
- Richard Ben Cramer - Narrator (voice)
- Garrison Keillor - Narrator (voice)
- Roy Scheider - Narrator (voice)
- Anna Deavere Smith - Narrator (voice)
- Morley Safer - Narrator (voice)
- Harris Yulin - Narrator (voice)
- Simon Russell Beale - John Adams (voice)
- Brian Paulette - Frank James
- Campbell Scott - Narrator (voice)
- Christopher Plummer - Narrator
- Marilyn Spanier - Annie Oakley (voice)
- Kenneth Branagh - Narrator (voice)
- Jeffrey Wright - Narrator (voice)
- Colm Feore - Narrator (voice)
- Kathy Bates - Narrator (voice)
- Ping Wu - Narrator (voice)
- Chris Cooper - Narrator (voice)
- Martin Luther King Jr. - Himself (archive footage)
- Nicholas Purcell - Charles Adams
- David Ogden Stiers - Narrator (voice)
- Bugsy Siegel - Self (archive footage)
- Roger Rees - William Bradford
- Richard Thomas - Narrator (voice)
- Sada Thompson - Narrator (voice)
- Len Cariou - Narrator (voice)
- Stephen Ives - Himself - Director
- Jesse Owens - Self
- Jeremy Schaap - Self
- Theodor Michael - Self
- Harry Edwards - Self
- Guy Walters - Self
- Rainer Rother - Self
- Oliver Platt - Narrator (voice)
- Oliver Platt - Narrator
- Louis Zamperini - Self
- Michael Murphy - Narrator (voice)
- Michael Murphy - Narrator
- Renée Elise Goldsberry - Narrator
- André Holland - Narrator
- Joanna Rhinehart - Narrator
- Kate Burton - Narrator
- Peter Krause - Narrator
- Lea Salonga - Narrator
- Vanessa Williams - Narrator (voice)
- Bahni Turpin - Zora Neale Hurston (voice)
- J. Hunter - Self
- Jim Jones - Self (archive footage)
- Leo J. Ryan - Self (archive footage)
- Julian Bond - Narrator (voice)
- Ronald Reagan - Self (archive footage)
- Donald Regan - Self
- Christine Jorgensen - Self (archive footage)
- Andre Braugher - Narrator
- Andre Braugher - Narrator (voice)
- Andre Braugher - Robert Carter (voice)
- Chris Dodd - Self
- Lee Wilkof - Dr. Walter Freeman (voice)
- Joanna Merlin - Family Member (voice)
- Judd Hirsch - (voice)
- Al Lewis - Self
- Lois Smith - (voice)
- George Plimpton - (voice)
- George Plimpton - Self (voice)
- Frances Sternhagen - (voice)
- Frances Sternhagen - Self (voice)
- Timothy Hutton - (voice)
- David Margulies - (voice)
- David Margulies - Self (voice)
- Beverly Gage - Self
- William Hitchcock - Self
- Sarah Churchwell - Self
- Steven Ross - Self
- Leah Wright Rigeur - Self
- Vladimir Lenin - Self (archive footage)
- Dorothy Thompson - Self (archive footage)
- J. Edgar Hoover - Self (voice) (archive footage)
- Kyle MacLachlan - Narrator
- Ron Vawter - Charles Guiteau
- Bart Whiteman - James Garfield
- Adolph Mall - Judge Cox
- Marty McDonough - District Attorney Cockhill
- Kevin Murray - Mr Jocelyn
- Mary Pickford - Self
- Douglas Fairbanks - Self
- Jeanine Basinger - Self
- Charlie Chaplin - Self
- D.W. Griffith - Self
- Amelia Earhart - Self
- Charles "Buddy" Rogers - Self
- Jack Pickford - Self
- Lottie Pickford - Self
- Hermann Göring - Self (archive footage)
- Benjamin Ferencz - Self
- Clarence Darrow - Self
- Franklin D. Roosevelt - Self
- Gutzon Borglum - Self
- Theodore Roosevelt - Self
- Corey Stoll - Narrator
- Jackson Walker - Daniel Ross
- Josh Blaylock - Young John Ross
- Benjamin Bratt - Narrator (voice)
- William J. Finley - Elias Boudinot
- Wesley French - John Ridge
- Robert Hatch - Missionary
- Ryan Lewis - Wealthy Plantation Owner
- Emily Podleski - Sarah Northrup
- Frederick Stuart - John Ross
- Wes Studi - Major Ridge
- Curtis LeMay - Self
- Robert Lansing - Narrator
- Marc Seifer - Self
- Louis Gossett Jr. - Self - Narrator
- Denzel Washington - Self - Narrator
- Matthew Broderick - Jack Binns (voice)
- Stephanie Castellarin - Hallie Davis (voice)
- Walter Cronkite - Self
- Walter Cronkite - Self (archive footage)
- Paul Guilfoyle - James Connolly (voice)
- John Maxtone-Graham - Self
- Bill Paxton - Self - Reader (voice)
- John Mahoney - (voice)
- Mary Bacon - Sally Thorpe
- Samuel Barnett - Philip's Schoolmate
- Gerry Bamman - Peter Fenner
- Lauren Bloom - Young Eliza Schuyler
- John Ellison Conlee - Shopkeeper Evans
- John Curless - David Hosack
- Michael Cumpsty - James Callender
- Richard Easton - George Washington
- Peter Gerety - Robert Bartlett
- Daniel Gerroll - Thomas Jefferson
- Neal Huff - Ephraim Slattery
- Neil McGarry - Aaron Burr
- Brian Murray - Gouverneur Morris
- Mark Nelson - Nathaniel Pendleton
- Denis O'Hare - Henry Lee
- Kelli O'Hara - Maria Reynolds
- Jamie Parker - Philip Hamilton
- Brandon Reilly - Young Hamilton in St. Croix
- Bridget Regan - Angelica Shippen
- Henry Strozier - John Adams
- Michael Stuhlbarg - Officer Stephen Colden
- Angela Thornton - Old Elizabeth Schuyler Hamilton
- Joanne Freeman - Self
- Kevin R. Hershberger - Continental Soldier
- Brían F. O'Byrne - Alexander Hamilton
- John Pagano - Continental Officer
- Matthew Arkin - Alexander Bickel (voice)
- Lyndon B. Johnson - Self (archive footage)
- Dan Rather - Self (archive footage)
- Rachel Maddow - Self
- Dwight D. Eisenhower - Self (archive footage)
Glenn Close interpreta a Narrator (voice) en la serie.
Robert Duvall interpreta a Narrator (voice) en la serie.
Randy Quaid interpreta a Narrator (voice) en la serie.
Tom Hanks interpreta a Narrator (voice) en la serie.
Christopher Plummer interpreta a Narrator en la serie.
Robert Redford interpreta a Narrator (voice) en la serie.
Mary McDonnell interpreta a Narrator (voice) en la serie.
Scott Glenn interpreta a Narrator (voice) en la serie.
Laura Linney interpreta a Narrator (voice) en la serie.
Jeffrey Wright interpreta a Narrator (voice) en la serie.
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