- Darnell Williams - Jesse Hubbard
- Chrishell Stause - Amanda Dillon
- Aiden Turner - Aidan Devane
- Ricky Paull Goldin - Jake Martin
- Debbi Morgan - Angie Hubbard
- James Mitchell - Palmer Cortlandt
- Jason Olive - Dr. Frank Hubbard
- Jesse McCartney - Adam 'J.R.' Chandler, Jr.
- Josh Duhamel - Leo du Pres
- Justin Bruening - Jamie Martin
- Mathew St. Patrick - Adrian Sword
- Olga Sosnovska - Lena Kundera
- Terri Ivens - Simone Torres
- Brittany Allen - Marissa Tasker
- Eden Riegel - Bianca Montgomery
- Mark Consuelos - Mateo Santos
- Julia Barr - Brooke English
- Marcy Walker - Liza Colby
- Cady McClain - Dixie Cooney
- Kathleen Noone - Ellen Shepherd
- Dorothy Lyman - Opal Cortlandt
- Matt Bomer - Ian Kipling
- Elizabeth Lawrence - Myra Murdock Sloane
- Louis Edmonds - Langley Wallingford
- Robert LuPone - Zach Grayson
- Warren Burton - Eddie Dorrance
- Francesca James - Kelly Tyler
- Michel Gill - Dr. Hawkins
- Mary Fickett - Ruth Parker Brent Martin
- Adam Mayfield - Scott Chandler
- Peter Bergman - Cliff Warner
- Bobbie Eakes - Krystal Carey
- Michael E. Knight - Tad Martin
- Susan Lucci - Erica Kane / Jane Campbell
- Susan Lucci - Erica Kane
- Céline Dion - Self
- Alexa Gerasimovich - Kathy Mershon
- Caroline Lagerfelt - Dr. Massey
- Sam Freed - Raymond Jenkins
- Michael B. Jordan - Reggie Porter Montgomery
- KaDee Strickland - Alison Waters
- Sarah Michelle Gellar - Kendall Hart
- Matthew Gumley - Scooter
- Jonathan Bennett - Adam 'J. R.' Chandler Jr.
- Bob Hiltermann - Walter Novak
- Frances Heflin - Mona Kane
- Jill Larson - Opal
- Ray MacDonnell - Joe Martin
- Colin Egglesfield - Joshua Madden
- Martin Thompson - Patrick
- Ruth Warrick - Phoebe Tyler
- Leslie Hendrix - Judge Hannah Lampert
- Ronald Guttman - Alexander Cambias
- Ronald Guttman - Alexander Cambias / Sheldon
- Matthew Arkin - Dr. Norton
- Alexa Havins - Babe Carey
- Patina Miller - Pam Henderson
- Brea Cola - Margie
- Jeff Branson - Jonathan Lavery
- Ambyr Childers - Colby Chandler
- Kelli Giddish - Di Henry
- Leven Rambin - Ava Benton
- Sabine Singh - Greenlee Smythe
- Will Kempe - Dr. Donovan Hillard
- Billy Miller - Richie Novak
- Tamara Braun - Reese Williams
- J.R. Martinez - Brot Monroe
- Brianne Moncrief - Colby Chandler
- Laila Robins - Claire Williams
- Anna Stuart - Mary Greenlee Smythe
- Denise Vasi - Randi Morgan
- McKenzie Westmore - Riley Sinclair
- Cornelius Smith, Jr. - Frankie Hubbard
- Adam Fiorentino - Simon Marshall
- Anna Koonin - Nurse Gayle
- Frank Runyeon - Forrest Williams
Capítulo disponible en las siguientes plataformas:
