- Liam Dunn - Mr. Fairchild
- Charles Durning - Detective
- Nedra Volz - Aunt Iola
- Terry Kiser - Bob
- Philip Carey - Steve
- George Wyner - Dr. Sidney Shapiro
- Rafael Campos - Emanuel
- Jack Weston - Joe Girgis
- Donald Randolph - Mr. Scott
- Robert Guillaume - Dr. Franklin
- Liz Torres - Teresa Betancourt
- Nita Talbot - Marcia
- Joseph Mascolo - Mr. Bushmill
- John Zaremba - Anesthetist
- Ron Glass - Jack
- Art Metrano - Jack
- Helen Page Camp - Nun
- James Gregory - William R. Kirkwood
- Allan Rich - Gallery Manager
- Demond Wilson - Horace
- Rae Allen - Amelia DeKuyper
- Neva Patterson - Ms. Maloney
- Katherine MacGregor - Nurse
- Mary Kay Place - Betty Sue
- John Alvin - Bailiff
- George Furth - Whitney Fitzroy IV
- Michael Conrad - Uncle Casimir
- Will Mackenzie - Reverend Schaeffer
- Rue McClanahan - Ruth Rempley
- Bill Macy - Uniformed Policeman
- Vic Tayback - Joe Tucker
- Mike Wagner - Leonard
- Clyde Kusatsu - Rev. Chong
- Bernadette Peters - Linda Galloway
- Alan Hamel - Ricky Buffano
- M. Emmet Walsh - Billy Hartfield
- Bea Arthur - Cousin Maude
- Eileen Brennan - Angelique McCarthy
- Victor Argo - Mr. Estrada
- Arlene Golonka - Tina
- Herb Voland - Ed Bradley
- Priscilla Lopez - Debbie Ballantine
- Joshua Shelley - Willie
- Michael Gregory - Jerry
- Janis Paige - Denise
- Robert Mandan - Mr. Morrison
- Vincent Gardenia - Curtis Rempley
- Henry Fonda - Self
- David Soul - Szabo Daborba
- Diane Shalet - Sheila Tishman
- Leslie Ackerman - Sharyn Talbot
- Cliff Osmond - Nick Howard
- Milton Selzer - Dr. Seymour Shapiro
- Howard Morton - Funeral Director
- Barnard Hughes - Father Majeski
- Abbey Lincoln - Laura Grant
- Doris Singleton - Lydia Stonehurst
- Tim O'Connor - Roy Johnson
- James Cromwell - Stretch Cunningham
- John Karlen - Leo
- Burt Mustin - Harry Feeney
- Bern Bennett - Sports Broadcaster (voice)
- Jenny Sullivan - Robin
- Charles Hallahan - Officer Harrison
- George S. Irving - Russell DeKuyper
- Charlotte Rae - Lillian Henderson
- Stephen Manley - Danny Sanders
- Jack Gilford - Bernard Bernstein
- Lee Bergere - Dean Winslow
- Angela Clarke - Mrs. Loretta Dillon
- Richard Ward - Ed Lewis
- F. Murray Abraham - Clerk
- Mike Kellin - Bummie Fencel
- John Harkins - Gordon Faraday
- Mel Stewart - George Jefferson
- Salem Ludwig - Solomon Rabinowitz
- Mike Evans - Lionel Jefferson
- Sorrell Booke - Joseph Sanders
- Sorrell Booke - Mr. Bennett
- Ian Wolfe - Herbert Hooper
- Roscoe Lee Browne - Hugh Victor Thompson III
- Charles Aidman - Mr. Willis
- Larry Storch - Bill Mulheron
- Ray Sharkey - Man At Clinic (uncredited)
- Sandy Kenyon - Dave the Cop
- Anthony Geary - Roger
- Garn Stephens - Dotty
- David Dukes - Lambert
- Darryl Hickman - Peter Grey
- Billy Sands - Nick
- Billy Sands - Bailiff (voice)(uncredited)
- Christopher Guest - Jim
- Jane Dulo - Nurse
- Roger C. Carmel - Mr. Ligway
- Richard Lawson - Angry Black Man
- James Hong - Doctor (uncredited)
- Roger Bowen - Mitch Turner
- Thalmus Rasulala - Mr. Byrd (as Jack Crowder)
- Cleavon Little - Coke
- Richard Masur - George
- Scott Brady - Joe Foley
- Richard Dysart - Russ DeKuyper
- Patty Weaver - Joanie
- Gene Blakely - Dr. Seymour Shapiro
- A Martinez - Manuel
- Theodore Bikel - Albrecht 'Alvin' Klemmer
- David Doyle - Jim Sanders
- Val Bisoglio - Ralph Silvestri
- Marcia Rodd - Marilyn Sanders
- John Randolph - Joe Peterson
- Joan Copeland - Elizabeth Tannen
- Elizabeth Wilson - Amelia DeKuyper
- Rod Loomis - Charlie
- Graham Jarvis - Larry Grundy
- Michael Alldredge - Policeman
- Billy Halop - Mr. Munson
- William Benedict - Jimmy McNab
- Roxie Roker - Helen Willis
- Corey Fischer - Jeff Walker
- Ruth Manning - Aunt Rose
- Joe Mantell - Sidney Schwartz
- Gloria LeRoy - Mildred 'Boom Boom' Turner
- Gloria LeRoy - Bobbi Jo
- Michael Mann - Dr. Dolby
- Michael Mann - Rev. Harris
- Jonelle Allen - Marabel
- Danny Dayton - Hank Pivnik
- Diane Sommerfield - Judy
- William Pierson - Wino
- Owen Bush - Charley
- Zara Cully - Mother Jefferson
- Zara Cully - Mrs. Jefferson
- Gregory Sierra - Paul Benjamin
- Maurice Marsac - Waiter (uncredited)
- Frank Aletter - Mr. Prescott
- Jon Korkes - Mr. Bradford
- J.A. Preston - Elmo 'Black Elmo' Bridgewater
- Frank Campanella - Det. Sgt. Perkins
- Allan Melvin - Barney
- Hector Elizondo - Carlos Mendoza
- Phyllis Avery - Sister Theresa
- Tyler McVey - 2nd Man
- Bob Hastings - Tommy Kelsey
- Richard Stahl - Clarence V. Marshall
- John Brandon - Cop
- Jeannie Linero - Nurse
- Ruth McDevitt - Jo
- Ruth McDevitt - Josephine 'Jo' Nelson
- Lynne Moody - Jennie
- Arny Freeman - Watkins
- Teddy Wilson - Whitey Monroe
- Franklin Cover - Tom Willis
- Barbara Cason - Claire Packer
- Estelle Parsons - Blanche Hefner
- Estelle Parsons - Dolores Mancheney Fencel
- Leonard Stone - Mr. Johnson
- Doris Roberts - Marge
- Jack Grimes - Mr. Whitehead
- Ellen Travolta - Secretary
- Elliott Reid - Harold Tannen
- Sammy Davis Jr. - Self
- Eugene Roche - Pinky Peterson
- Michael Pataki - Sgt. Roselli
- Michael Pataki - Lichtenrauch
- Harvey Lembeck - Sam
- Harvey Lembeck - Wally
- Beatrice Colen - Nurse
- Paulene Myers - Judge Frances MacKenzie
- Jack Somack - Tony Vicino
- Jason Wingreen - Harry Snowden
- Victor Kilian - Mr. Burkvist
- Victor Kilian - Clerk
- Ray Henderson - Bilkey
- John Putch - Boy Scout
- Peggy Rea - Bertha
- Bill Quinn - Mr. Van Ranseleer
- Jane Connell - Sybil Gooley
- Peter Hobbs - Judge Polanski
- Bernie Hamilton - Walter
- Betty Garrett - Irene Lorenzo
- Bob Dishy - David Green
- Paul Benedict - Harry Bentley
- Ed Peck - Man on Phone
- Ed Peck - Officer
- Bibi Osterwald - Mrs. Henshaw
- Gerald Hiken - Frank Edwards
- Mark Lonow - Pete Gavaris
- Ken Lynch - Guard Callahan
- Dennis Patrick - Gordie Lloyd
- Dennis Patrick - Mr. Scanlon
- Edith Diaz - Serafina Mendoza
- Raymond O'Keefe - Man #2
- Louis Guss - Sam
- Louis Guss - Delivery Man
- K Callan - Veronica Cartright
- James Greene - Charles Martin
- Nancy Stephens - Anita
- Connie Sawyer - Mrs. McNab
- Florence Halop - Martha Linfoot
- Billy Crystal - Al Bender
- Kim Hamilton - Mrs. Willis
- Phil Leeds - Mr. Stanley
- Phil Leeds - Sol Kleeger
- Berlinda Tolbert - Jenny Willis
- Patrick Cronin - Brian Schlemmer
- Isabel Sanford - Louise Jefferson
- Isabel Sanford - Mrs. Jefferson
- James O'Rear - Mr. Dundee
- Madeleine Fisher - Vikki
- Greg Mabrey - Dr. Culver
- Tom Fitzsimmons - Frank
- Rich Little - Richard Nixon (voice) (uncredited)
- Holly Near - Mona
- Jack Bender - Paul Goodrow
- Hollis Irving - Clara Weidermeyer
- Jack Perkins - The Drunk
- Keith Taylor - Pizza King Delivery Guy (Uncredited)
- William Windom - Eddie Frazier
- Brendan Dillon - Tommy Kelsey
- Brendan Dillon - Bartender
- Brendan Dillon - Tommy Kelsey (uncredited)
- George Savalas - Joe Frouge
- Will B. Able - Rev. Felcher
- Herbie Faye - The Deliveryman
- Charles Siebert - Young Man
- Charles Siebert - Rabbi
- Charles Siebert - D.A.
- Len Lesser - Billy Pendergast
- Harrison Page - Black Hippie in Jail (uncredited)
- Frank Whiteman - The Policeman
- Ida Mae McKenzie - Mrs. Edwards
- Robert R. Barry - Man at the Door
- Phil Proctor - Wendell
- Jack Griffin - Bill Hopper
- Neil J. Schwartz - Levy
- Priscilla Morrill - Nurse
- Priscilla Morrill - Kate Korman
- Priscilla Morrill - Sarah
- Priscilla Morrill - Bernice
- Noam Pitlik - Wilbur
- Jeannie Linero - The Waitress
- Fay DeWitt - Mrs. Haskell
- Keri Shuttleton - Clarissa
- Hector Elias - Alfredo Estrada
- Dianne Hull - Linda
- James McEachin - Mr. Turner
- Diana Hale - IRS Agent (uncredited)
- Ken Sansom - IRS Agent (uncredited)
- Lynnette Mettey - Susan (uncredited)
- Norman Lear
- Morton Lachman
- Hal Kanter
- Milt Josefsberg
- Bernie West
- Bill Davenport
Victor Argo interpreta a Mr. Estrada en la serie.
M. Emmet Walsh interpreta a Billy Hartfield en la serie.
Ken Lynch hace el papel de Guard Callahan.
Henry Fonda interpreta a Self en la serie.
Phil Leeds hace el papel de Sol Kleeger.
Leonard Stone interpreta a Mr. Johnson en la serie.
F. Murray Abraham hace el papel de Clerk.
Hector Elizondo hace el papel de Carlos Mendoza.
Charles Durning interpreta a Detective en la serie.
Clyde Kusatsu interpreta a Rev. Chong en la serie.
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