- James Urbaniak - Miles Van Ert
- Lesley Boone - Rose
- Meagen Fay - Miriam Fry
- Alexander Carroll - Agent Yauch
- Neal McDonough - Dum-Dum Dugan
- Leonard Roberts - Sam Sawyer
- Richard Short - Pinky Pinkerton
- Ralph Brown - Dr. Ivchenko
- Toby Jones - Arnim Zola
- Currie Graham - Calvin Chadwick
- Lotte Verbeek - Ana Jarvis
- Sarah Bolger - Violet
- Sean O'Bryan - Andrew Henry
- Kurtwood Smith - Vernon Masters
- Chris Browning - Rufus Hunt
- Ray Wise - Hugh Jones
- Ken Marino - Joseph Manfredi
- Matt Braunger - Dr. Samberly
- Casey Sander - Thomas Gloucester
- Randy Sklar - Director Kenneth
- Max Brown - Michael Carter
- Samaire Armstrong - Wilma Cully
- Olivia Scott Welch - Teen Agnes Cully
- Rey Valentin - Agent Vega
- Chris Mulkey - Oncle Bud
- Tina D'Marco - Nonna Manfredi
- Tom Choi - Dr. Chung
- Russell Edge - Agent Blackwell
- Christopher Grove - Mr. Edwards
- Madonna Cacciatore - Ovechkin's Mom
- Hope Lauren - Gorgeous Blonde
- Lincoln Melcher - Emmett Dooley
- Ashley Grace - Colleen O'Brien
- Bill Kalmenson - Senator Webster
- Costa Ronin - Anton Vanko
- Andre Royo - Spider Raymond
- Kevin Heffernan - Madison Avenue Guy
- Johnny Marques - Bartender
- Carrick O'Quinn - Tall Bouncer
- Don Luce - Mob Boss
- Atticus Todd - Winston
- Joseph Wilson - Gino DeLucia
- James Frain - Leet Brannis
- James Landry Hébert - Sasha Demidov
- Rob Mars - Jerome Zandow
- Laura Coover - Molly
- Christie Herring - Emily
- Tim James - Jimmy
- Paul Roache - Building Manager
- Rick Steadman - Automat Customer
- Jack Conley - Ernst Mueller
- Gregory Sporleder - Otto Mink
- Sarah Schreiber - Lorraine
- Benita Robledo - Carol
- Meagan Holder - Vera
- Joanna Strapp - Gloria
- Billy Malone - Large Smuggler
- Jeremy Timmins - Larger Smuggler
- Jim Palmer - Goon
- Chad Dashnaw - Thug
- Stan Lee - Man on Bench
- Greg Serano - Rick Ramirez
- Eddie Shin - Mike Li
- James Austin Kerr - Junior Juniper
- Alex Veadov - Nikola
- John Glover - SSR Informant
- Vladimir Tevlovski - Leviathan Soldier
- J. Anthony McCarthy - Pete
- Veronika Bonell - 10 Year Old Dottie
- Caitlin Carmichael - 10 Year Old Anya
- Chiara Aurelia - 10 Year Old Eva
- Rick Peters - Seth Honicky
- Yasmine Aker - Thelma Crawford
- Devin Ratray - Sheldon McFee
- Krista Marie Yu - Edith Oberon
- Steven Hack - Albert
- Dimiter D. Marinov - Fyodor
- Victoria Profeta - Josephine
- Joyce Greenleaf - Esther
- Sarah Bloom - Loretta Dooley
- Travis Johns - Agent Corcoran
- Kevin Cotteleer - Alex Doobin
- Pawel Szajda - Ovechkin
- Rob Locke - Surgeon
- Diana Gettinger - Usherette
- Mary-Beth Manning - Woman
- Chris Palermo - Middle-Aged Man
- Sandra Lee Gimpel - Elderly Woman
- Glenn Taranto - Prendergast
- Ralph Garman - Announcer
- Ralph Garman - Radio Announcer
- John Prosky - Walt Cooper
- DaJuan Johnson - Officer Pike
- Kevin Ashworth - Agent Fisher
- Patrick Robert Smith - Agent Wallace
- Gerald Webb - Gary Tower
- Alex Daniels - Mechanic
- Christopher Poehls - Ground Crewman
- Matt Raimo - Reporter
- Ward Roberts - Reporter
- Kirsten Vangsness - Ruby (uncredited)
- Gabriella Graves - Young Peggy
- John Gilbert - Elderly Teller
- Bruce Katzman - Meltzer
- Edward Deraney - SSR Agent
- Alex Alcheh - Rookie Cop
- Nick Hoffa - Restaurant Owner
- Robert Buscemi - Concierge
- Angela Cristantello - Isodyne Receptionist
- Patrick Quinlan - EMT
- John Balma - Torrance
- Clayton Norcross - Sheriff
- Kevin Changaris - Fred
- Carole Ruggier - Mrs. Carter
- Tamika Katon-Donegal - Mabel
- Ivy George - Young Agnes
- Khalilah Joi - Ticket Lady
- Jonathan LaVallee - FBI Agent
- Catriona Toop - Bletchley Girl
- Jennifer Neala Page - Bletchley Girl
- Alexandra Vino - Bombshell Secretary
- Ryan Sturz - Roxxon Guard
- Malosi Leonard - Goon
- Christopher Allen - Agent Ryan
- Arielle McFadden - Nurse
- Sean Bolger - Guard
- Alva Loomis - LAPD Officer
- Myles Grier - Man
- Damian O'Hare - Nick Driscoll
- Brian Glanney - Agent Ford
- Timothy Thomas Brown - Snub Nose
- Tim Soergel - Paul
- Bert Rotundo - Ralph
- Lon Gowan - Truck Driver
- Dominic Cooper - Howard Stark
- Chris Coppola - Hank
- Reggie Austin - Jason Wilkes
- Erin Torpey - Radio Actor "Betty Carver"
- Jeff Locker - Lab Tech
- John Bishop - Frank
- Tim DeZarn - George
- Hayley McCarthy - Melody
- Jared Gertner - Cryptographer
- Kevin Feige
- Sara E. White
- Christopher Markus
- Stephen McFeely
- Louis D'Esposito
- Stan Lee
- Daniel Colman
- Robert Carr
- Dave Jordan
- Amber Funk
- Mark D. Fleming
- Christopher Lennertz
Kurtwood Smith interpreta a Vernon Masters en la serie.
Neal McDonough interpreta a Dum-Dum Dugan en la serie.
Damian O'Hare interpreta a Nick Driscoll en la serie.
Hayley Atwell interpreta a Peggy Carter en la serie.
James D'Arcy interpreta a Edwin Jarvis en la serie.
Enver Gjokaj interpreta a Daniel Sousa en la serie.
Wynn Everett interpreta a Whitney Frost en la serie.
Capítulo disponible en las siguientes plataformas:
