- Jonathan Hale - Professor Roberts
- Maurice Cass - Meldini
- John Crawford - Jack Morrell
- William Forrest - Mr. Crane
- Herbert Rawlinson - Rozan
- Jack Kruschen - First Airport Robber
- Victor Sen Yung - Harry Wong
- Henry Kulky - Crusher (uncredited)
- John Banner - Bronsky
- Robert J. Wilke - Bingham
- Patrick Aherne - Murray
- Tris Coffin - Mr. Stoddard
- Maudie Prickett - Mrs. Matilda Tazey
- Bobby Barber - Tony the Masseur
- Murray Alper - Sanders
- Arthur Space - Dr. Wilson
- Jack Pepper - Custodian
- Olaf Hytten - Jarvis
- Stanley Andrews - Sam Garvin
- Joe Kirk - Gangster with Binoculars (uncredited)
- Lois Hall - Mrs. Winters
- Marshall Reed - Inspector Hill
- Rhys Williams - Macy
- Ray Bennett - Stan Hacker
- Pierre Watkin - Airline Official
- Louis Jean Heydt - Pawley
- James Seay - Bill Hurd
- Percy Helton - Hamlet
- Barbra Fuller - Sally
- Steve Pendleton - Lynch
- Peter Whitney - Capt. McBain
- Leon Askin - Joseph Ferdinand
- Dale Van Sickel - Baker
- Dale Van Sickel - Slim's Partner
- Jane Frazee - Farmwoman
- Ted Hecht - Ahmed
- Dabbs Greer - Joe Winters
- Mabel Albertson - Kate White
- Denver Pyle - Emile Hatch
- Trevor Bardette - Bet-a-Million Butler
- Anthony Caruso - Luigi Dinelli
- Mickey Simpson - Hercules
- Myrna Fahey - Miss Dunn
- Vic Perrin - Scurvey
- Frank Jenks - Lazy
- Henry Corden - William Johnson / Legbo
- Dennis Moore - Officer Riley
- George Eldredge - John Salem
- George Eldredge - Thomas Wingate
- Robert Rockwell - Jor-El (uncredited)
- Jean Willes - Marion Cummings
- Jim Hayward - Tim Mallory
- Roy Gordon - Postello
- Russell Johnson - Man on Phone in Montage (archive footage)
- Sterling Holloway - Prof. Oscar Quinn
- Ric Roman - Nate
- Selmer Jackson - Col. Jack Redding
- Selmer Jackson - Gen. Summers
- Herb Vigran - Mortimer Murray
- Herb Vigran - Mugsy Maple
- Herb Vigran - Legs Leamy
- Rudolph Anders - Dr. Rudolf Albrecht
- Don Dillaway - Fred Harris
- George "Spike" Hamilton - Dr. Simon Jerrod
- Dean Cromer - Mickey
- Jeffrey Silver - Teenaged Clark Kent (uncredited)
- Harold Goodwin - Brakeman
- Robert Tafur - Vice-President Oberon
- Judy Nugent - Ann Carson
- Kay Morley - Elaine Carson
- Raymond Greenleaf - Dr. Anderson
- Paul Fix - Ollie
- Paul Fix - Gangster in Montage (archive footage)
- Paul Fix - Fingers
- James Brown - Jim Carson
- Sam Flint - Warden
- Sam Flint - Eben's Doctor (uncredited)
- Cyril Delevanti - King of Sartania
- Laurie Mitchell - Ruby
- Jack Reitzen - Ali Zing
- Jack Reitzen - Philippe Gonzalez
- Everett Glass - Prof. La Serne
- Hal Taggart - Informant (uncredited)
- John Phillips - Man at the Election Booth
- Milton Kibbee - Harry Hansen
- Charles Williams - Yo Yo
- Charles Williams - Tim
- Fred Sherman - Inspector Sims
- Fred Sherman - Dr. Oscar Jessup
- Sarah Padden - Mrs. Carmody
- Dan Seymour - Gangster in Montage (archive footage)
- Dan Seymour - Lou Cranek
- Myron Healey - Paul Craymore
- Myron Healey - Gunner Flinch
- Ray Montgomery - Tyler
- Ray Montgomery - Jeff
- Helen Wallace - Woman on Phone in Montage (archive footage)
- Helen Wallace - Mrs. Olsen, Jimmy's Mother
- Philip Van Zandt - Regan
- Philip Van Zandt - Nick Marone
- Joseph Mell - The Professor
- Lane Bradford - Capt. Chris White
- Lane Bradford - Al
- John Eldredge - Mr. X
- John Eldredge - Walter Canby
- John Eldredge - Jonas Rockwell
- John Eldredge - Burt Burnside
- Billy Gray - Alan Harper
- Paul Burke - Ace
- Paul Burke - Rosy
- Wayne Heffley - Duke Barlow
- Larry J. Blake - Rausch, the Henchman
- Larry J. Blake - Steve Martin
- Keith Richards - Rutherford Jones
- Keith Richards - A Henchman
- Keith Richards - Steve Barton
- Ruta Lee - Claire - High School Girl
- John Harmon - Clicker
- John Harmon - Skinny
- Ralph Sanford - Buckets
- Ralph Sanford - George - Customer
- Joseph Vitale - Cap
- Chuck Connors - Sylvester J. Superman
- Norma Varden - Mabel McCredy
- Leonard Mudie - Capt. Blood
- Leonard Mudie - Brockhurst the Magician
- Leonard Mudie - Prof. Jody
- Leonard Mudie - Leland Masters
- Eve Brenner - Betty
- Eve Brent - Woman
- John Doucette - Joe
- John Doucette - Slugger
- John Doucette - Foster
- Maurice Marsac - Marcel Duval
- Maurice Marsac - Orresto el Centro Jones
- Sol Gorss - Sailor (uncredited)
- Sid Tomack - Curtis
- Sid Tomack - Ruffles
- Jack Daly - Witness in Montage (archive footage)
- Jack Daly - Dogcatcher
- Jack Daly - Mr. Perkins
- Dick Rich - Toots
- Richard Reeves - Bad Luck Brannigan
- Richard Reeves - Frenchy
- Richard Reeves - Little Jack
- Richard Reeves - Stacey Tracy
- Richard Reeves - Babe
- Peter Brocco - Dr. H.L. Ort
- Peter Brocco - Crackers
- Peter Brocco - The Spectre
- Lyn Thomas - Waitress
- Lyn Thomas - Ann - a Phony Nurse
- George E. Stone - Big George
- George E. Stone - Duke Taylor
- William Challee - Mack (uncredited)
- William Challee - Max
- Douglas Henderson - Noodles
- John George - Dwarf in Pool Hall (uncredited)
- Frank Mills - Voter (uncredited)
- Frank Mills - Reward Seeker (uncredited)
- Louis Mercier - LaRue
- Ben Welden - Lefty
- Ben Welden - Curley
- Ben Welden - Carni
- Ben Welden - 'Leftover' Louie Lyman
- Ben Welden - Hank
- Ben Welden - Gangster in Montage (archive footage)
- Ben Welden - Nosey
- Ben Welden - Jody Malone
- Ben Welden - Blade
- Howland Chamberlain - Fisher / Dr. Albert Schumann
- Raymond Hatton - Jonathan Crag / Craymore
- Raymond Hatton - Sagebrush
- Raymond Hatton - Grandfather Jackson
- Mauritz Hugo - Tiger
- Mauritz Hugo - Luke Palmer
- Mauritz Hugo - Slim
- John Baer - Kreuger (unconfirmed)
- Dick Gordon - Reporter (uncredited)
- Dick Gordon - Scientist (uncredited)
- Dick Gordon - Onlooker at Customs (uncredited)
- Herschel Graham - Scientist (uncredited)
- Milton Wood - Mr. Bergeret
- Cecil Elliott - Elsa
- James Craven - John Greer
- Gloria Saunders - Lily
- Lou Lubin - Small Henchman
- Ted Ryan - Large Henchman
- John Maxwell - Studio Police Chief
- Jane Adams - Babette DuLoque
- Lou Krugman - Jacques Olivier
- Al Eben - Big Ed Bullock
- Lewis L. Russell - W.T. Wayne
- John Kellogg - Turk
- William E. Green - Governor
- Houseley Stevenson - Pop Polgase
- Edmund Cobb - Lafe Reiser
- June Foray - Doll (uncredited)
- Virginia Christine - Mrs. Frank
- Frank Ferguson - Mr. Frank
- Doris Singleton - Gloria Harper
- Damian O'Flynn - J. W. Gridley
- Damian O'Flynn - Dr. Ralph Harper
- Steve Conte - Thug #2
- Fred Essler - Scientist Jan Moleska (uncredited)
- Peter Mamakos - Happy King
- Joseph Forte - Prof. Adams
- Robert Carson - Allen
- Gregg Barton - Sheriff
- Tom London - Peter Thomas
- Julie Bennett - Sometimes Mabel
- Milton Frome - Faraday
- Milton Frome - Lank Garrett
- Milton Frome - Mr. Gannis
- John Cliff - Heavy
- Paul E. Burns - Mr. Whitlock
- Paul E. Burns - Lu Song
- Billy Nelson - Larry McCoy
- Billy Nelson - Knuckles Nelson
- Billy Nelson - Muscles McGurk
- Billy Nelson - Louie
- Billy Nelson - Sully
- Frank J. Scannell - Canfield
- Paul Bryar - Scott
- John Merton - Doc
- Joey Ray - Marty Mitchell
- Lester Dorr - Bus Driver
- Lester Dorr - Man at Well
- Clark Howat - Professor Roberts' Assistant
- Tom Moore - Shop Owner
- Russell Custer - Police Officer (uncredited)
- Phil Tead - Prof. Pepperwinkle
- John Vivyan - Duke
- Sherry Moreland - Bank Teller
- Nacho Galindo - Alberto
- Al Kikume - Native Chief
- Leon Lontoc - Witch Doctor
- Billy Wayne - Rollo
- Harry Mendoza - Sung Lo Too (magician)
- George Douglas - Security Guard
- Jan Arvan - Max
- Tom Monroe - Diver
- Tom Powers - Railroad Official
- Renny McEvoy - Carnival Barker
- Robert Bice - Bennett
- Wes Hudman - Dock Hand
- Charles Anthony Hughes - Doctor
- Ron Hargrave - Boy Mayor
- Robert Crosson - Boy Police Chief
- Lawrence Ryle - Dr. Gregory Barnak
- Jean Dean - Alma
- Anthony De Mario - March
- Jerry Siegel
- Joe Shuster
- Robert H. Justman
- Robert Maxwell
Percy Helton hace el papel de Hamlet.
George E. Stone interpreta a Duke Taylor en la serie.
Sol Gorss interpreta a Sailor (uncredited) en la serie.
Jack Kruschen interpreta a First Airport Robber en la serie.
George Reeves interpreta a Superman en la serie.
Noel Neill hace el papel de Lois Lane.
John Hamilton interpreta a Perry White en la serie.
Jack Larson hace el papel de Jimmy Olsen.
Robert Shayne interpreta a Inspector Henderson en la serie.
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