- Alexandra Bastedo - Penny Caspar-Morse
- James Lance - Daniel
- Jeillo Edwards - Jeillo
- Nickolas Grace - Jonny
- Celia Imrie - Claudia Bing
- Natascha McElhone - Art Gallery Assistant
- John Wells - Uncle Humphrey
- Mark Wing-Davey - Malcolm
- Richard E. Grant - Dream Justin
- Miranda Richardson - Bettina
- Kate O'Mara - Jackie Stone
- Mariella Frostrup - Self
- Emma Pierson - Kasha
- Jean-Paul Gaultier - Self
- Crispin Bonham-Carter - Jago Balfour
- Robert Lindsay - Pete
- James Dreyfus - Christopher
- Eleanor Bron - Patsy's Mother
- Rupert Penry-Jones - Boy at Party
- Orla Brady - Nurse Mary
- Meera Syal - Suzy
- Gwen Humble - Sondra Lorrance
- Dale Winton - Self
- Lulu - Self
- Lulu - Herself
- Naoko Mori - Sarah
- Minnie Driver - Self
- Kevin Allen - Ben
- Rebecca Front - Cherysh
- Paul Reynolds - Squeak
- Tim Woodward - Headmaster Tony Simmonds
- Kristin Scott Thomas - Plum Berkeley
- Dora Bryan - Dolly
- Fern Britton - Self
- Perou - Photographer
- Philip Franks - Poet
- Leigh Lawson - Self
- Gary Beadle - Oliver
- Elton John - Sir Elton John
- Idris Elba - Hilton
- Lisa Coleman - Joanna
- Naomi Campbell - Self
- Daniela Denby-Ashe - Saffy's Daughter Victoria
- Tim Wylton - Brice
- Clarissa Dickson Wright - Clarissa
- Patrick Barlow - Max
- Twiggy - Self
- Christopher Malcolm - Justin
- Kathy Burke - Magda
- Suzy Aitchison - 1970s Nurse
- Ruby Wax - Beth De Woodi
- Ian Gelder - David
- Peter Richardson - Tony
- Harriet Thorpe - Fleur
- Suzi Quatro - Dream Nurse
- Sam Spedding - Booberella Actor
- Christopher Ryan - Marshall
- Sylvia Anderson - Lady Penelope
- Josie Lawrence - Cable TV Presenter
- Emma Bunton - Self
- Emma Bunton - Herself
- Germaine Greer - Dream Mother
- Britt Ekland - Self
- Mo Gaffney - Bo
- Antony Cotton - Damon
- Jo Brand - Carmen
- Zandra Rhodes - Self
- Adrian Edmondson - Hamish
- Llewella Gideon - Nurse
- Mandy Rice-Davies - Dream Patsy
- Katy Wix - Annabelle
- Miranda Hart - Yoko
- Dawn French - Kathy
- Jennifer Saunders
- Dawn French
- Jon Plowman
Helena Bonham Carter interpreta a Dream Saffron en la serie.
Joanna Lumley interpreta a Patsy en la serie.
Julia Sawalha interpreta a Saffron en la serie.
June Whitfield interpreta a Mother en la serie.
Jane Horrocks interpreta a Bubble en la serie.
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