- Carrie Snodgress - Mrs. Cranston
- Rob Stone - Jed
- Ronee Blakley - Gina Sherman
- Albert Hague - Prof. Steinberg
- Beth Howland - Eleanor Flemming
- John Karlen - Joe Farrell
- Katharine Ross - Maggie's Mother
- Carl Weintraub - Peter
- Don Murray - Jack Karpinsky
- Lycia Naff - Bernice Sherman
- Cindy Pickett - Joanne Kelly
- Adam Sandler - Drug Dealer
- Ernie Lively - Jack Harmon
- Stan Kirsch - Matt
- Jessica Alba - Christy
- Vincent Van Patten - Mark (voice)
- John Lupton - Mr. Adams
- Kenneth Kimmins - Father
- Christopher Knight - Joe
- Alex Karras - Alex 'Moose' Novak
- Eduard Franz - Grandpa
- Alfred Lutter - Eric
- Kristy McNichol - Jenna McPhail
- Nora Denney - Receptionist
- Billy Jayne - Ivan
- Mercedes Ruehl - Sandy
- Perry Lang - Hewitt Calder
- Lauri Hendler - Teague Harrington
- Alexa Kenin - Gerri Pattison
- Michael Biehn - Seth
- Holland Taylor - Felicia Martin
- Al Corley - Jack Peters
- Michael Currie - Dr. Mudd
- Danny Aiello - Dominic Ginetti
- Lee Curreri - Steve
- Karin Argoud - Renie Lake
- Corey Parker - David
- Seth Green - Tommy Sanders
- Kyra Sedgwick - Cindy Eller
- Matt Clark - Phil Cranston
- Allison Balson - Jed's Girlfriend
- David Margulies - Justin
- James Noble - Max Smiley
- Megan Follows - Dana Sherman
- John Savage - Bernie Morton
- Charles Siebert - Mr. McNeil
- Pat Benatar - Donna
- Wil Wheaton - Nick Karpinsky
- Emily Schulman - Anna
- Kristin Dattilo - Allison Street
- Andrea Elson - Liz
- Lisa Robin Kelly - Ashley
- Helen Kleeb - Emily
- James Pritchett - Tom
- Katy Kurtzman - Joss
- Molly Dodd - Mrs. Bayliss
- Med Flory - John McPhail
- Joseph Mascolo - Mr. Singleton
- Russell Johnson - Mr. Calder
- Clark Brandon - Mark Henderson
- Stephen Elliott - Dan Meredith
- Inga Swenson - Mrs. Marston
- Trini Alvarado - Dena McKain
- Melora Hardin - Amy Warner
- Jay O. Sanders - Mr. Miller
- Jere Burns - Hal
- John Getz - Thomas Sanders
- Debra Mooney - Mrs. Anderson
- Robert DoQui - Sgt. Corbett
- Grant Show - Gregory Prince III
- Malcolm-Jamal Warner - Charlie Curtis
- Stephen Mailer - Mickey Sherman
- Bernie Kopell - Tom Warner
- Sparky Marcus - Young Tuck
- Sparky Marcus - Tootie
- Maria Tucci - Marie Mills
- Priscilla Morrill - Aunt Willie
- Eric Scott - Eric
- Eric Scott - David
- Fran Bennett - Nurse Etting
- Alison Elliott - Cindy
- Ike Eisenmann - Joey Grant
- Ike Eisenmann - Larry (voice)
- Vince Vaughn - Jason
- Jennifer Grey - Laura Eller
- Jennifer Grey - Carol Schwartz
- Mara Hobel - Rose Ann Ginetti
- Mara Hobel - Vanessa
- Jenny O'Hara - Irene Harmon
- Robbie Rist - Raymond
- Rance Howard - Myron Faraday
- Dave Madden - Coach Puckett
- Peggy McCay - Mrs. Calder
- Bob Hastings - Harry Harrington
- Priscilla Pointer - Ruth Meredith
- Peggy Rea - Mrs. Atwater
- Marcia Rodd - Barbara McKain
- Lindsay Crouse - Louise Sanders
- John Glover - Mr. Stewart
- Michele Greene - Andrea Cranston
- Patricia Kalember - Maria Acero
- Uta Hagen - Omi
- Lin McCarthy - Russell Lake
- Tammy Lauren - Colleen McNeil
- James Sutorius - Mr. Sanders
- Debbi Morgan - Celia
- Patricia Stevens - Tuck's Mother
- Larry Gelman - Luncheonette Owner
- Kim Richards - Minnow
- Kim Richards - Missey
- Miriam Colon - Yolanda
- Lauren Tom - Sarah
- Melba Moore - Ms. Varady
- Allison Smith - Maggie
- Kerry MacLane - Tom
- Peter Brandon - Mr. Arthur
- Yeardley Smith - Jenny
- Sam McMurray - Trendy Liberal
- Jean De Baer - Tiffany
- Mary Kay Place - Ellie Skinner
- Christopher Maleki - Palumbo
- Christopher Maleki - C.C.
- Jonathan Ward - Ben
- Michelle Pfeiffer - Annie
- Anne Seymour - Dr. Bancroft
- Anne Seymour - Miss Pemberthy
- Val Kilmer - Eric
- Gabrielle Carteris - Cecile
- Gabrielle Carteris - Leslie
- Mare Winningham - Beth
- Grace Zabriskie - Mrs. Linton
- Bibi Besch - Marlene Lake
- Bibi Besch - Coach
- Sarah Jessica Parker - Suzanne Henderson
- Garrett M. Brown - John Henderson
- Mary Elaine Monti - Helen Henderson
- Christopher Curry - Surveyor
- Jodie Foster - Sharon Lee
- Jodie Foster - Sue
- Vicky Dawson - Jen
- Vicky Dawson - Laura
- Vicky Dawson - Lisa
- Ben Affleck - Danny Coleman
- Will Smith - Hawker
- Laura Dean - Alison
- Laura Dean - Ginger Ginetti
- Madeline Kahn - Ellie Coleman
- Rob Lowe - Charles Elderberry
- Stephen Keep Mills - Michael Skinner
- Stephen Keep Mills - Mr. Eller
- Rita Karin - Mrs. Reuben
- Cindy Eilbacher - Marge
- Cindy Eilbacher - Elva Grimes
- Pam Potillo - Melanie
- Keith Szarabajka - Peter Desmond
- Lance Kerwin - Ezzie
- Lance Kerwin - P.J. / The President's Son
- Lance Kerwin - Adam Rush
- Lance Kerwin - Peter Finley
- Lance Kerwin - Buzz
- Candy Trabuco - Woman on Bus
- Melanie Mayron - Sue
- Allison Marra - Passenger
- Chad Burton - Super
- Reed Diamond - Charlie
- Reed Diamond - Gary Farrell
- Peter Onorati - (uncredited)
- John Gielgud - Various Roles
- Ralph Richardson - Various Roles
- Lynn Redgrave - Various Roles
- Simon Ward - Various Roles
- Paul Jones - Various Roles
- Nicholas Clay - Various Roles
- Sasha Jenson - Rick
- Lennie Weinrib - Timer (voice)
- Sarah Kennedy - Little Red (voice)
- Diane Murphy - Carol (voice)
- Joan Gerber - Mother / Adeline / Diane (voice)
- Lance Guest - Tim
- Lance Guest - Doug Henshaw
- Michael Link - Joey
- Peter Broderick - Joey (voice)
- Kathy Buch - Missey (voice)
- Willie Aames - Kid at Gumball Machine
- Hal Smith - Uncle Carl
- Hal Smith - Professor Latouche (voice)
- Drake Bell - Scott
- Lynn Hamilton - Mrs. Ellis
- Knowl Johnson - Duck Levine
- Keith Coogan - Matt Thompson
- Michael St. Gerard - Bobby Stewart
- Sam Rockwell - Jason
- Olivia Barash - Eugenie
- Michael Barbera - Young Michel (voice)
- Rita Lynn - Madame Footy (voice)
- Donna Vivino - Kendall Bard
- Rosalind Chao - The Kurmese Ambassador's Daughter
- Gabrielle Beaumont
- Melissa Gilbert
- Robert Mandel
- Tom Blank
- Jim Gates
- Stephen Gyllenhaal
- Jameson Brewer
- Mary Pleshette Willis
- George Mendoza
- William Shakespeare
- Larry Spiegel
- Courtney Flavin
- Joseph Barbera
- William Hanna
- Friz Freleng
- Judith Stoia
- Dick Clark
- Debra Di Maio
- Jonathan Sheffer
- Dean Elliott
- Michel Legrand
- Edward Newmark
Carrie Snodgress interpreta a Mrs. Cranston en la serie.
Rob Stone interpreta a Jed en la serie.
Ronee Blakley hace el papel de Gina Sherman.
Albert Hague interpreta a Prof. Steinberg en la serie.
Beth Howland hace el papel de Eleanor Flemming.
John Karlen interpreta a Joe Farrell en la serie.
Katharine Ross interpreta a Maggie's Mother en la serie.
Carl Weintraub interpreta a Peter en la serie.
Don Murray hace el papel de Jack Karpinsky.
Lycia Naff interpreta a Bernice Sherman en la serie.
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