- Andy Buckley - John Fitzgerald Kennedy Jr.
- Jessica Tuck - Lorraine Murrey
- Sarah Michelle Gellar - Teenage Jacqueline Bouvier
- Eve Gordon - Marilyn Monroe
- Bob Gunton - Hugh Auchincloss
- Boyd Gaines - Yusha Auchincloss
- Anna Thomson - Ilona
- Nick Gregory - Clay Holmby
- Lisa Eichhorn - Dr. Jordan
- Mary McMillan - Martha Bartlett
- David Petersen - James Lee
- Ralph Cosham - Dr. Wilson
- Ann Buckles - Gossip Columnist
- Kate Skinner - Woman Reporter
- Stephen Pearlman - City Editor
- Walt MacPherson - Man on Street
- Kathleen Goldpaugh - Woman on Street
- Nadia Dajani - Christina Onassis
- Jad Mager - Alex Onassis
- Brian Smiar - Lyndon B. Johnson
- Carlin Glynn - Lady Bird Johnson
- Clark Gregg - Ken O'Donnell
- Nan Martin - Diana Vreeland
- Mark Metcalf - George Smathers
- Michael O'Gorman - Coleman
- Jack Ryland - Larry O'Brien
- Sam Stoneburner - Andre Meyer
- Nicholas Walker - Peter Lawford
- Tom Todoroff - Mr. Kenneth
- John Leonard Thompson - Ex-boyfriend
- Nancy Youngblut - Press Secretary
- Paul D'Elia - Reception Guest
- Joss Ackland - Aristotle Onassis
- Robin Morse - Adult Caroline Kennedy
- Gary Wade Morton - N Street Photographer
- David Gibbs - Waiter (uncredited)
- Larry Peerce
- Roger O. Hirson
- C. David Heymann
- Lester Persky
- Lalo Schifrin
Stephen Collins interpreta a John Fitzgerald Kennedy en la serie.
Josef Sommer interpreta a Joseph Kennedy Sr. en la serie.
Rosemary Murphy interpreta a Rose Kennedy en la serie.
William Devane hace el papel de Black Jack Bouvier.
Kathleen McNenny interpreta a Ethel Kennedy en la serie.
Wendy Hughes interpreta a Janet Lee Bouvier en la serie.
Ashley Crow interpreta a Lee Bouvier Radziwill en la serie.
Tim Ransom interpreta a Robert Kennedy en la serie.
Andy Buckley interpreta a John Fitzgerald Kennedy Jr. en la serie.
Jessica Tuck interpreta a Lorraine Murrey en la serie.
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