- Tristan Byon - Theo Saville
- Stephanie Szostak - Delilah Dixon
- Ron Livingston - Jon Dixon
- Floriana Lima - Darcy Cooper
- Enuka Okuma - Sandra
- Sam Huntington - Tom
- Ricky He - Don
- Rob LaBelle - Gene
- Nathan Witte - Mark
- Dante Basco - Cory
- Tanner Stine - KC
- Henderson Wade - Hunter
- Chris Humphreys - Dr. Martin
- Emmy Raver-Lampman - Rebecca
- Donna Benedicto - Kendra
- Alanna Ubach - Dawn
- June Kyoto Lu - Joo Hee
- Richard Kind - Seymour
- James Tupper - Andrew Pollock
- Jennifer Ashton - Dr. Jennifer Ashton
- L. Scott Caldwell - Renee Howard
- Jay Pharoah - Omar
- Drea de Matteo - Barbara Nelson
- Rhys Coiro - Mitch
- Chandler Riggs - PJ
- Brian Scolaro - Brian
- Jenny O'Hara - Enid
- Niecy Nash-Betts - Gloria
- Bodhi Sabongui - Elliot
- Julian Acosta - Max
- Jessie Fraser - Jackie
- Scott Patey - Dashiell
- Andy Thompson - Principal Taylor
- JayR Tinaco - Stevie
- Ashley Wood - Jess
- Conor Wylie - Gavin
- Paul Guilfoyle - Lenny
- Caitlin Stryker - Susan
- Shauna Johannesen - Karen
- Elan Ross Gibson - Abigail
- Leo Chiang - Wayne
- Carla Jimenez - Elena
- Veronika Hadravá - Kay
- Andy Nez - Vincent
- Jason Ritter - Eric
- Jerry Ferrara - Todd
- Sutton Foster - Chloe
- Seneca Paliotta - Skyler Burns
- B.J. Britt - Isaac Martin
- Tyler Cody - Jake
- Stephi Chin-Salvo - Becky
- Romy Rosemont - Shelly
- Melora Hardin - Patricia
- Helenna Santos - Teller
- Michelle Choi-Lee - Nurse
- Parker Young - Miles
- Betsy Brandt - Colleen Stewart
- Olivia Steele-Falconer - Alex Stewart
- Aleita Northey - Georgia
- Ebboney Wilson - Eve
- Moneca Delain - Cailey
- Ryan Beil - Louis
- Carolyn Tinglin - Surgical Nurse
- Brian Johnston - State Trooper
- Greta Carew-Johns - Cassie
- Jeffrey Joseph - Dr. Heller
- Gerard Plunkett - Reverend Stewart
- Ryan Mah - Clark
- Jaiven Natt - Tyler
- Natasha Leggero - Joyce
- Leana Yu - Real estate agent
- Matty Finochio - Teddy
- Synthia Yusuf - Hannah
- Anna Akana - Dakota
- Sprague Grayden - Lindsay Saville
- Michael Adamthwaite - Albert
- Jonah Lietzau - Singer (uncredited)
- Peter Benson - Trevor Matlof
- Chris Geere - Jamie
- Terry Chen - Alan
- Adam Swain - Tyrell
- Rachel Nichols - Nicole
- Lochlyn Munro - Coach
- Mizinga Mwinga - Larry
- Viv Leacock - Sully
- Ash Lee - Dr. Lee
- Gerald McRaney - Lenny Farache
- Lennon Parham - Gail
- Paul Jarrett - Principal McIsaac
- Neil Webb - Keith
- Derek Green - Dr. Cohen
- Jenn MacLean-Angus - Dr. Mathers
- Dylan Sloane - Chad
- Veenu Sandhu - Dr. Jansen
- Lou Beatty Jr. - Walter Howard
- Marissa Jaret Winokur - Linda
- Jordan R. Coleman - Kevin
- Jordan R. Coleman - Keith
- Leandro Guedes - Jack
- Ken Tremblett - Henry
- Chris Shields - Dr. Ehrlich
- Evelyn Burke - Young Sophie
- Trent Redekop - Christmas Tree Guy
- Sam Pancake - Carter French
- Sebastian Kroon - Truck Driver
- Lauren Lapkus - Mallory
- Elizabeth Weinstein - Veterinarian
- Constance Zimmer - Jeri Huntington
- Constance Zimmer - Mourner
- Maggie Ma - Host
- Karen Robinson - Florence Davis
- Vanessa Prasad - Receptionist
- Madeleine Kelders - EMT #1
- Sonia Beeksma - Reporter
- Philip Cabrita - Guy in Line
- John Innes - Priest
- Leeah Wong - Peggy
- Jamall Johnson - Security Guard
- Shane Twerdun - Firefighter
- Brian Cook - Bruins Fan
- Scott J. Ateah - Bruins Fan
- Diana Pavlovská - Judge Silva
- Scott McNeil - Randy
- Joel Cottingham - Mr. Andrews
- Todd Matthews - Samuel Benson
- Arlina Rodríguez - Beth
- Gregory Tunner - Jorge
- Wonser De-Gbon - Nurse
- Cameron Crosby - Keyboardist
- Cameron Crosby - Drummer
- Cameron Crosby - Teddy
- Naomi King - Announcer
- Jesse Muhoozi - Kid
- Danny Dworkis - Man
- Matthew Harrison - Bank Manager
- Fletcher Donovan - Jared
- Taz VanRassel - Husband
- Rosie Frier-Dryden - Dorothy
- Matt Oberg - Waiter
- Julian Christopher - Mover
- Chad Rook - Shelton
- Reed Birney - Eugene Bloon
- Neil Charlesworth - Man
- Ryan Hesp - Lead Exec
- Barry W. Levy - Cal
- Myrasol Martinez - Receptionist
- Klarc Jerome Wilson - Bike Courier
- Bronson Pinchot - Berge
- Chris Nowland - Frank Jordano
- Jake T. Roberts - Gus
- Lindsey Gort - Joanna
- Wesley Salter - Owen
- Darren Dolynski - Dr. Anthony
- Ingo M. Holst - Orderly
- Malia Baker - Little Girl
- Leo Thomas - Bartender
- Serge Jaswal - Nurse
- Lee Shan Gibson - Policeman
- Jennifer Kitchen - Robin
- Adam Thomas - Doctor
- Lia Lam - Nurse
- Natalie Trent - Grace
- Brandy Le - Luis
- Derek Kwan - Scrub Tech
- Jasmine Lukuku - Lizzie
- Anita Barone - Sophie
- Edward Ruttle - Dave
- Aaron Read - Tour Guide
- Brendan Riggs - Clerk
- Samuel Francisco - New Dad
- Natalie von Rotsburg - Gift Shop Clerk
- Quinnie Vu - Dana
- Quinnie Vu - Brenda
- Farrah Aviva - Lucy
- Jeb Beach - Doctor
- Bonnie Hay - Leader
- Bonnie Hay - Eileen
- Aadila Dosani - Julie
- Nelson Franklin - Elon
- Jaleese Green - Sarah
- John Shaw - Christopher
- Marco Soriano - Maître D'
- Debbie Podowski - Wendy
- Jason McKinnon - Ken
- Jannen Karr - Nancy
- Mat Lo - Maître D'
- Meghan Drew - Emily
- Janet Glassford - Drama Teacher
- Donald Sales - Dustin
- Mark Gash - Doctor
- Yuta Takenaka - Organ Donor Rep
- Jason Asuncion - Vendor
- Tyler McConachie - Businessman
- Angela Trimbur - Tessa
- Sunita Prasad - Tammy Blakely
- Annette Reilly - Helen
- Ramon Terrell - Nate
- Steve Annan - Carl
- Lennora Esi - Andrea
- Sei Campbell - Host
- Cristina Rosato - Debra Pollock
- Jay Zhang - Coworker
- Katrina Reynolds - Carol
- Mike Dopud - Officer Maddox
- Kalvin Olafson - Bryan
- Morgana Wyllie - Lauren
- Oscar Hartley - Caleb
- Jonté LeGras - Young Walter
- Candus Churchill - Ann
- Sheila Tyson - Joyce
- Robin T. Rose - Minister
- Akiz Aguma - Young Rome
- Erica Cerra - Tara Simone
- Kurt Long - Doctor
- Brad Kelly - Man
- Pippa Mackie - Clair
- Mark Anthony Pariñas - Stage Manager
- Jayce Barreiro - Officer
- Blake Stadel - Coach
- Marcia Gay Harden - Alice Mendez
- Blythe Hubbard - Taylor
- Bronwen Smith - Saleswoman
- Craig Haas - Josh
- Hector Johnson - Judge
- Jessie Liang - Nurse
- Robert Corness - Owner
- Destiny Millns - Avery
- Troy Mundle - Bailiff
- Jan Bos - Dr. Stein
- Angela Moore - Dr. Thune
- Shauna Hansen - Patient
- Tim Zhang - Jamie
- Steve Dhillon - Elliot's Dad
- Jimmy Kimmel - Jimmy Kimmel (voice)
- Michael Drayer - Derek
- Keisha Haines - Trisha
- Jag Bal - Anton
- Kheon Clarke - Bodyguard
- Sunny Chen - Woman
- Todd Thomson - Dale
- Yoshie Bancroft - Hotel Clerk
- Ellen Ewusie - Cheryl Higgins
- Anthony Bolognese - Liam
- Amanda Marier - Hotel Notary
- Saul Camargo - Game Master Dave
- Braedon Cox - Bartender
- Lillian Doucet-Roche - Young Lindsay
- Karen Holness - Cindi
- Milo Shandel - Father
- Deborah Ramsay - Mrs. Stewart
- Cardi Wong - Marty
- Nikolas Dukic - Teenage Son
- Abbi Donovan - Young Colleen
- Tom McBeath - Flannel Shirt Man
- Nevin Burkholder - Carnival Worker
- Logan Tarasoff - Rowdy Customer
- Ashley O'Connell - Cabbie
- Veena Sood - Nurse Shayna
- Matt Ward - Isaac Martin
- Keeya King - Tennille
- Daylin Willis - Taylor
- Andrew Leeds - Peter Benoit
- Erin Karpluk - Anna
- Kimi Alexander - Teresa
- Cameron Alexander Andres - Henry
- Andrew Barber - Ron
- Allan Luna - Soldier
- Nisreen Slim - Reception Nurse
- Magda Ochoa - Cancer Patient
- Theresa Wong - Dr. Stacey Adams
- Harris Allan - Devon
- Kim Wylie - Mother
- Francisca Dennis - Moderator
- Patrick Rinehart - NA Member (Todd)
- Romeo Reyes - NA Member
- Kris McRonney - NA Member
- Chris West - NA Member
- Susan Hanson - Joo Hee Kim
- Susie Lee - CPS Worker
- Chris Cound - Neighbor
- Bobbi Charlton - Jackie
- Víctor Ayala - Counselor
- Amanda Wong - Nora
- Andrea Savage - Dr. Stacy
- Jenny Brizard - Martine
- Jillian Fargey - Dr. Reeves
- Gary Sanghera - Dr. Wolman
- Jason Wong - Professor Kennedy
- Paul Rodríguez - Javier Mendez
- Elle McKinnon - Jen
- Erin Aubrey - Madame Berkner
- Andrea Bang - Claudia
- Jason Riki Kosuge - Security Guard
- Michael Weston - Christopher Gregory
- Kari Matchett - Georgia Gregory
- Paul McGillion - Dr. Anton
- Miranda Edwards - Nya Byrne
- Winson Won - Technician
- Rob Huebel - Xander Holmes
- Emily Giannozio - Layla
- Chris Webb - Brandon
- Brian Markinson - Detective Craig Saunders
- Adam Greydon Reid - Kyle
- Alex Vishniakoff - Mr. Mills
- Dumisile Owane - Officer Anderson
- Nadeen Lightbody - Nurse
- Edwin Rodriguez - Manny
- Laura Lyall - Marce
- Laura Lyall - Amanda
- Stephnie Weir - Jane Goodman
- Kurt Evans - Brandon
- Eric Regimbald - Martin Tisdale
- Michael Patrick Thornton - Russ
- Mark Derwin - Nick
- Glynis Davies - Cheryl
- Neemish Parekh - Manager
- Jaeda Owens - Kiana
- Cecilly Day - Singing Server
- Olivia Poon - Woman
- Tariq Leslie - Bob
- Jorden Birch - Greg
- Andrea Navedo - Valerie Sandoval
- Jill Morrison - Rachel
- Primo Allon - Joel
- Donny Lucas - Austin
- Kathleen Duborg - Nurse
- Toby Berner - Gerald
- Aidan Drummond - Edgar
- Ruth Bidner - Crocodilze Hostess
- Ryan Hansen - Camden Lamoureux
- Kristina Lao - Doctor
- Wei Chung - Production Assistant
- Mario Van Peebles - Ronald
- Azie Tesfai - Cassandra Thomas
- Meghan Gardiner - Sarah
- Christopher Logan - Anthony
- Ambika Vas - Shannon
- Peter Chao - Delivery Guy
- AJ Crivello-Jones - Man
- Ian Hawkins - Husband
- Emma Leduc - Fan
- Jessica Lee - Real Estate Agent
- Mya Lowe - Monica
- Arianna McGregor - Property Master
- Walcott E. Morgan - Custodian
- Chris Wood - Stanley
- Don Mike - 1st Assistant Director
- Emma Rendell - Wife
- Leia Bajic - Sasha
- Danny Wattley - Bulldog
- Clara Alexandrova - Morgan
- Shawn Stewart - Phil
- Arghavan Jenati - Samantha
- Francesca Bianchi - Heather
- Baraka Rahmani - Carly
- Greg Csiszar - Team Manager
- Derek Richardson - Stephen
- Michelle Creber - Jenna
- Mark Chavez - Professor
- Shiraine Haas - Fay
- Gillian Hurtig - Audrey
- David Attar - Passenger
- Donia Kash - Meetra
- Elisa Paszt - Vali
- Cheryl Swan - Meredith
- Paul Almeida - Rider
- Laura Mitchell - Becca
- Marcel Zadé - Kyle
- Cameron Esposito - Greta Strobe
- Tammy Hui - Receiving Doctor
- Lydia Campbell - ER Nurse
- Edem Nyamadi - EMT
- Colm Hill - EMT
- Shaun Morse - Cam Fan
- Prince Justin Atkinson - Security Guard
- Keith D. Robinson - Dre Washington
- Sam Anderson - Mr. Dennings
- Lee Shorten - Randy Kwan
- Christopher J. Hanke - Dr. Ashley Anderson
- Stephanie Lavigne - Receptionist
- Stephanie Lavigne - Eloise
- Tebo Nzeku - Kendra Davis
- Gelsea Mae - Nurse
- Dan Bucatinsky - Harrison
- Steph Song - Dr. Jacobs
- Pam Kearns - Dottie
- Mirella Gibeau - Carole Feldman
- Katrina Kwan - Nurse
- Colin Hay - Colin Hay
- Jessica Lindsey - Julia
- Robyn Ross - Carly
- Amanda May - Susan Jeffries
- Tim Howe - Guy
- Joshua Pak - Organizer
- Sakura Sykes - Hostess
- Gabrielle Jacinto - Customer
- Laura K. MacDonald - Fan
- Nicole Muñoz - Vali
- Jude Wilson - Kevin
- Kelsey Lopes - Brianna
- Sharmaine Yeoh - Woman
- Andrea Abreu - Jen
- Liana Liberato - Kai
- Melody Nosipho Niemann - Kiana
- Andres Collantes - Benjamin Hernandez
- Andres Collantes - Benny Hernandez
- Lisa Kimberley - Lauren
- Larry MacDonald - Janitor
- Dylan Ratzlaff - Clare
- Caroline Cave - Isabelle Ainsworth
- Sebastien Roberts - Clark Ainsworth
- Matt Clarke - Desk Clerk
- Randall Hua - Table Attendant
- Ron Robinson - Leader
- Sydney Bell - Joanie
- Rohain Arora - Officer Puri
- David Marshall Grant - Gene Grant
- Teagan Vincze - Joyce
- Jessica St. Clair - Amelia
- Kuba Oms - Joseph
- Bresha Webb - Dr. Jessica Bruno
- David Walton - Colton Cutler
- Shyinne Anastacio - Waitress
- Roraigh Falkner - Young Dad
- Katherine Haysbert - Young Mom
- Justin Singh - Larry
- Eduard Witzke - Attendant
- Lily Yawson - Police Officer
- Dana Gourrier - Melissa
- Jace Fleming - Lars
- Adrian Formosa - Herb
- Nicco Del Rio - Tim
- Ty Barnett - Evan Fisher
- Johanna Braddy - Claire Fisher
- Dwain Murphy - Terrence
- Clare Filipow - Brie
- Andrew McNee - Graham
- Chanelle Peloso - Celeste
- Heather Feeney - Cindee
- Silvana Estifanos - Molly
- Annabelle Loi - Intake Vet Nurse
- Jesse Stretch - Unhoused Man
- Liz Vassey - Dr. Craft
- Thalia Campbell - Daniella
- Nicholas Elia - Jet
- Lisa Huynh - Marie
- Patti Kim - Diane
- Andrew Woo - Male Student
- Tara Pratt - Carol
- Renée Victor - Inez
- Mary-Beth Manning - Councilwoman Dottie Lewis
- Zahf Paroo - Raju Perera
- Cassandra Consiglio - Receptionist
- Jennifer Rose Garcia - April
- Sarah Almonte Peguero - Nurse
- JoBeth Williams - Lana Strobe
- George Wyner - Lonny Strobe
- Christopher Lloyd - Christopher Lloyd
- Chris Robson - Teacher
- Joe Costa - Tyrone
- Robyn Bradley - Sandra
- Sook Hexamer - Elderly Woman
- Linden Banks - Doctor
- Wanda Ayala - Nurse
- Lisa Paxton - School Nurse
- Michael Hogan - Tim
- BJ Harrison - Melinda
- Caitlin Howden - Kirsten
- Kavandeep Hayre - Young Man
- Daniel Bacon - Lukasz / Bartender
- Serge Houde - Captain
- Eric Yue - Man
- Marlene Ginader - Nurse
- Lance Lim - Adult Theo
- Josh Zaharia - Teen Javi
- Agnes Tong - Mishelle Lybell
- Audrey Wise Alvarez - Lana
- Reanna Cameron - Adult Charlie
- Andy Canete - Doctor
- Alia Domino - Nurse
- Marshall Boone
- D.J. Nash
- Aaron Kaplan
- David Marshall Grant
Christopher Lloyd interpreta a Christopher Lloyd en la serie.
Bronson Pinchot hace el papel de Berge.
Marcia Gay Harden hace el papel de Alice Mendez.
Jenny O'Hara hace el papel de Enid.
Melora Hardin interpreta a Patricia en la serie.
Paul Guilfoyle interpreta a Lenny en la serie.
David Giuntoli hace el papel de Eddie Saville.
Romany Malco hace el papel de Rome Howard.
James Roday Rodriguez interpreta a Gary Mendez en la serie.
Christina Moses interpreta a Regina Howard en la serie.
Capítulo disponible en las siguientes plataformas:
