- Tristan Byon - Theo Saville
- Stephanie Szostak - Delilah Dixon
- Ron Livingston - Jon Dixon
- Floriana Lima - Darcy Cooper
- Enuka Okuma - Sandra
- Sam Huntington - Tom
- Ricky He - Don
- Rob LaBelle - Gene
- Nathan Witte - Mark
- Dante Basco - Cory
- Tanner Stine - KC
- Henderson Wade - Hunter
- Chris Humphreys - Dr. Martin
- Emmy Raver-Lampman - Rebecca
- Donna Benedicto - Kendra
- Alanna Ubach - Dawn
- June Kyoto Lu - Joo Hee
- Richard Kind - Seymour
- James Tupper - Andrew Pollock
- Jennifer Ashton - Dr. Jennifer Ashton
- L. Scott Caldwell - Renee Howard
- Jay Pharoah - Omar
- Drea de Matteo - Barbara Nelson
- Rhys Coiro - Mitch
- Chandler Riggs - PJ
- Brian Scolaro - Brian
- Jenny O'Hara - Enid
- Niecy Nash-Betts - Gloria
- Bodhi Sabongui - Elliot
- Julian Acosta - Max
- Jessie Fraser - Jackie
- Scott Patey - Dashiell
- Andy Thompson - Principal Taylor
- JayR Tinaco - Stevie
- Ashley Wood - Jess
- Conor Wylie - Gavin
- Paul Guilfoyle - Lenny
- Caitlin Stryker - Susan
- Shauna Johannesen - Karen
- Elan Ross Gibson - Abigail
- Leo Chiang - Wayne
- Carla Jimenez - Elena
- Veronika Hadravá - Kay
- Andy Nez - Vincent
- Jason Ritter - Eric
- Jerry Ferrara - Todd
- Sutton Foster - Chloe
- Seneca Paliotta - Skyler Burns
- B.J. Britt - Isaac Martin
- Tyler Cody - Jake
- Stephi Chin-Salvo - Becky
- Romy Rosemont - Shelly
- Melora Hardin - Patricia
- Helenna Santos - Teller
- Michelle Choi-Lee - Nurse
- Parker Young - Miles
- Betsy Brandt - Colleen Stewart
- Olivia Steele-Falconer - Alex Stewart
- Aleita Northey - Georgia
- Ebboney Wilson - Eve
- Moneca Delain - Cailey
- Ryan Beil - Louis
- Carolyn Tinglin - Surgical Nurse
- Brian Johnston - State Trooper
- Greta Carew-Johns - Cassie
- Jeffrey Joseph - Dr. Heller
- Gerard Plunkett - Reverend Stewart
- Ryan Mah - Clark
- Jaiven Natt - Tyler
- Natasha Leggero - Joyce
- Leana Yu - Real estate agent
- Matty Finochio - Teddy
- Synthia Yusuf - Hannah
- Anna Akana - Dakota
- Sprague Grayden - Lindsay Saville
- Michael Adamthwaite - Albert
- Jonah Lietzau - Singer (uncredited)
- Peter Benson - Trevor Matlof
- Chris Geere - Jamie
- Terry Chen - Alan
- Adam Swain - Tyrell
- Rachel Nichols - Nicole
- Lochlyn Munro - Coach
- Mizinga Mwinga - Larry
- Viv Leacock - Sully
- Ash Lee - Dr. Lee
- Gerald McRaney - Lenny Farache
- Lennon Parham - Gail
- Paul Jarrett - Principal McIsaac
- Neil Webb - Keith
- Derek Green - Dr. Cohen
- Jenn MacLean-Angus - Dr. Mathers
- Dylan Sloane - Chad
- Veenu Sandhu - Dr. Jansen
- Lou Beatty Jr. - Walter Howard
- Marissa Jaret Winokur - Linda
- Jordan R. Coleman - Kevin
- Jordan R. Coleman - Keith
- Leandro Guedes - Jack
- Ken Tremblett - Henry
- Chris Shields - Dr. Ehrlich
- Evelyn Burke - Young Sophie
- Trent Redekop - Christmas Tree Guy
- Sam Pancake - Carter French
- Sebastian Kroon - Truck Driver
- Lauren Lapkus - Mallory
- Elizabeth Weinstein - Veterinarian
- Constance Zimmer - Jeri Huntington
- Constance Zimmer - Mourner
- Maggie Ma - Host
- Karen Robinson - Florence Davis
- Vanessa Prasad - Receptionist
- Madeleine Kelders - EMT #1
- Sonia Beeksma - Reporter
- Philip Cabrita - Guy in Line
- John Innes - Priest
- Leeah Wong - Peggy
- Jamall Johnson - Security Guard
- Shane Twerdun - Firefighter
- Brian Cook - Bruins Fan
- Scott J. Ateah - Bruins Fan
- Diana Pavlovská - Judge Silva
- Scott McNeil - Randy
- Joel Cottingham - Mr. Andrews
- Todd Matthews - Samuel Benson
- Arlina Rodríguez - Beth
- Gregory Tunner - Jorge
- Wonser De-Gbon - Nurse
- Cameron Crosby - Keyboardist
- Cameron Crosby - Drummer
- Cameron Crosby - Teddy
- Naomi King - Announcer
- Jesse Muhoozi - Kid
- Danny Dworkis - Man
- Matthew Harrison - Bank Manager
- Fletcher Donovan - Jared
- Taz VanRassel - Husband
- Rosie Frier-Dryden - Dorothy
- Matt Oberg - Waiter
- Julian Christopher - Mover
- Chad Rook - Shelton
- Reed Birney - Eugene Bloon
- Neil Charlesworth - Man
- Ryan Hesp - Lead Exec
- Barry W. Levy - Cal
- Myrasol Martinez - Receptionist
- Klarc Jerome Wilson - Bike Courier
- Bronson Pinchot - Berge
- Chris Nowland - Frank Jordano
- Jake T. Roberts - Gus
- Lindsey Gort - Joanna
- Wesley Salter - Owen
- Darren Dolynski - Dr. Anthony
- Ingo M. Holst - Orderly
- Malia Baker - Little Girl
- Leo Thomas - Bartender
- Serge Jaswal - Nurse
- Lee Shan Gibson - Policeman
- Jennifer Kitchen - Robin
- Adam Thomas - Doctor
- Lia Lam - Nurse
- Natalie Trent - Grace
- Brandy Le - Luis
- Derek Kwan - Scrub Tech
- Jasmine Lukuku - Lizzie
- Anita Barone - Sophie
- Edward Ruttle - Dave
- Aaron Read - Tour Guide
- Brendan Riggs - Clerk
- Samuel Francisco - New Dad
- Natalie von Rotsburg - Gift Shop Clerk
- Quinnie Vu - Dana
- Quinnie Vu - Brenda
- Farrah Aviva - Lucy
- Jeb Beach - Doctor
- Bonnie Hay - Leader
- Bonnie Hay - Eileen
- Aadila Dosani - Julie
- Nelson Franklin - Elon
- Jaleese Green - Sarah
- John Shaw - Christopher
- Marco Soriano - Maître D'
- Debbie Podowski - Wendy
- Jason McKinnon - Ken
- Jannen Karr - Nancy
- Mat Lo - Maître D'
- Meghan Drew - Emily
- Janet Glassford - Drama Teacher
- Donald Sales - Dustin
- Mark Gash - Doctor
- Yuta Takenaka - Organ Donor Rep
- Jason Asuncion - Vendor
- Tyler McConachie - Businessman
- Angela Trimbur - Tessa
- Sunita Prasad - Tammy Blakely
- Annette Reilly - Helen
- Ramon Terrell - Nate
- Steve Annan - Carl
- Lennora Esi - Andrea
- Sei Campbell - Host
- Cristina Rosato - Debra Pollock
- Jay Zhang - Coworker
- Katrina Reynolds - Carol
- Mike Dopud - Officer Maddox
- Kalvin Olafson - Bryan
- Morgana Wyllie - Lauren
- Oscar Hartley - Caleb
- Jonté LeGras - Young Walter
- Candus Churchill - Ann
- Sheila Tyson - Joyce
- Robin T. Rose - Minister
- Akiz Aguma - Young Rome
- Erica Cerra - Tara Simone
- Kurt Long - Doctor
- Brad Kelly - Man
- Pippa Mackie - Clair
- Mark Anthony Pariñas - Stage Manager
- Jayce Barreiro - Officer
- Blake Stadel - Coach
- Marcia Gay Harden - Alice Mendez
- Blythe Hubbard - Taylor
- Bronwen Smith - Saleswoman
- Craig Haas - Josh
- Hector Johnson - Judge
- Jessie Liang - Nurse
- Robert Corness - Owner
- Destiny Millns - Avery
- Troy Mundle - Bailiff
- Jan Bos - Dr. Stein
- Angela Moore - Dr. Thune
- Shauna Hansen - Patient
- Tim Zhang - Jamie
- Steve Dhillon - Elliot's Dad
- Jimmy Kimmel - Jimmy Kimmel (voice)
- Michael Drayer - Derek
- Keisha Haines - Trisha
- Jag Bal - Anton
- Kheon Clarke - Bodyguard
- Sunny Chen - Woman
- Todd Thomson - Dale
- Yoshie Bancroft - Hotel Clerk
- Ellen Ewusie - Cheryl Higgins
- Anthony Bolognese - Liam
- Amanda Marier - Hotel Notary
- Saul Camargo - Game Master Dave
- Braedon Cox - Bartender
- Lillian Doucet-Roche - Young Lindsay
- Karen Holness - Cindi
- Milo Shandel - Father
- Deborah Ramsay - Mrs. Stewart
- Cardi Wong - Marty
- Nikolas Dukic - Teenage Son
- Abbi Donovan - Young Colleen
- Tom McBeath - Flannel Shirt Man
- Nevin Burkholder - Carnival Worker
- Logan Tarasoff - Rowdy Customer
- Ashley O'Connell - Cabbie
- Veena Sood - Nurse Shayna
- Matt Ward - Isaac Martin
- Keeya King - Tennille
- Daylin Willis - Taylor
- Andrew Leeds - Peter Benoit
- Erin Karpluk - Anna
- Kimi Alexander - Teresa
- Cameron Alexander Andres - Henry
- Andrew Barber - Ron
- Allan Luna - Soldier
- Nisreen Slim - Reception Nurse
- Magda Ochoa - Cancer Patient
- Theresa Wong - Dr. Stacey Adams
- Harris Allan - Devon
- Kim Wylie - Mother
- Francisca Dennis - Moderator
- Patrick Rinehart - NA Member (Todd)
- Romeo Reyes - NA Member
- Kris McRonney - NA Member
- Chris West - NA Member
- Susan Hanson - Joo Hee Kim
- Susie Lee - CPS Worker
- Chris Cound - Neighbor
- Bobbi Charlton - Jackie
- Víctor Ayala - Counselor
- Amanda Wong - Nora
- Andrea Savage - Dr. Stacy
- Jenny Brizard - Martine
- Jillian Fargey - Dr. Reeves
- Gary Sanghera - Dr. Wolman
- Jason Wong - Professor Kennedy
- Paul Rodríguez - Javier Mendez
- Elle McKinnon - Jen
- Erin Aubrey - Madame Berkner
- Andrea Bang - Claudia
- Jason Riki Kosuge - Security Guard
- Michael Weston - Christopher Gregory
- Kari Matchett - Georgia Gregory
- Paul McGillion - Dr. Anton
- Miranda Edwards - Nya Byrne
- Winson Won - Technician
- Rob Huebel - Xander Holmes
- Emily Giannozio - Layla
- Chris Webb - Brandon
- Brian Markinson - Detective Craig Saunders
- Adam Greydon Reid - Kyle
- Alex Vishniakoff - Mr. Mills
- Dumisile Owane - Officer Anderson
- Nadeen Lightbody - Nurse
- Edwin Rodriguez - Manny
- Laura Lyall - Marce
- Laura Lyall - Amanda
- Stephnie Weir - Jane Goodman
- Kurt Evans - Brandon
- Eric Regimbald - Martin Tisdale
- Michael Patrick Thornton - Russ
- Mark Derwin - Nick
- Glynis Davies - Cheryl
- Neemish Parekh - Manager
- Jaeda Owens - Kiana
- Cecilly Day - Singing Server
- Olivia Poon - Woman
- Tariq Leslie - Bob
- Jorden Birch - Greg
- Andrea Navedo - Valerie Sandoval
- Jill Morrison - Rachel
- Primo Allon - Joel
- Donny Lucas - Austin
- Kathleen Duborg - Nurse
- Toby Berner - Gerald
- Aidan Drummond - Edgar
- Ruth Bidner - Crocodilze Hostess
- Ryan Hansen - Camden Lamoureux
- Kristina Lao - Doctor
- Wei Chung - Production Assistant
- Mario Van Peebles - Ronald
- Azie Tesfai - Cassandra Thomas
- Meghan Gardiner - Sarah
- Christopher Logan - Anthony
- Ambika Vas - Shannon
- Peter Chao - Delivery Guy
- AJ Crivello-Jones - Man
- Ian Hawkins - Husband
- Emma Leduc - Fan
- Jessica Lee - Real Estate Agent
- Mya Lowe - Monica
- Arianna McGregor - Property Master
- Walcott E. Morgan - Custodian
- Chris Wood - Stanley
- Don Mike - 1st Assistant Director
- Emma Rendell - Wife
- Leia Bajic - Sasha
- Danny Wattley - Bulldog
- Clara Alexandrova - Morgan
- Shawn Stewart - Phil
- Arghavan Jenati - Samantha
- Francesca Bianchi - Heather
- Baraka Rahmani - Carly
- Greg Csiszar - Team Manager
- Derek Richardson - Stephen
- Michelle Creber - Jenna
- Mark Chavez - Professor
- Shiraine Haas - Fay
- Gillian Hurtig - Audrey
- David Attar - Passenger
- Donia Kash - Meetra
- Elisa Paszt - Vali
- Cheryl Swan - Meredith
- Paul Almeida - Rider
- Laura Mitchell - Becca
- Marcel Zadé - Kyle
- Cameron Esposito - Greta Strobe
- Tammy Hui - Receiving Doctor
- Lydia Campbell - ER Nurse
- Edem Nyamadi - EMT
- Colm Hill - EMT
- Shaun Morse - Cam Fan
- Prince Justin Atkinson - Security Guard
- Keith D. Robinson - Dre Washington
- Sam Anderson - Mr. Dennings
- Lee Shorten - Randy Kwan
- Christopher J. Hanke - Dr. Ashley Anderson
- Stephanie Lavigne - Receptionist
- Stephanie Lavigne - Eloise
- Tebo Nzeku - Kendra Davis
- Gelsea Mae - Nurse
- Dan Bucatinsky - Harrison
- Steph Song - Dr. Jacobs
- Pam Kearns - Dottie
- Mirella Gibeau - Carole Feldman
- Katrina Kwan - Nurse
- Colin Hay - Colin Hay
- Jessica Lindsey - Julia
- Robyn Ross - Carly
- Amanda May - Susan Jeffries
- Tim Howe - Guy
- Joshua Pak - Organizer
- Sakura Sykes - Hostess
- Gabrielle Jacinto - Customer
- Laura K. MacDonald - Fan
- Nicole Muñoz - Vali
- Jude Wilson - Kevin
- Kelsey Lopes - Brianna
- Sharmaine Yeoh - Woman
- Andrea Abreu - Jen
- Liana Liberato - Kai
- Melody Nosipho Niemann - Kiana
- Andres Collantes - Benjamin Hernandez
- Andres Collantes - Benny Hernandez
- Lisa Kimberley - Lauren
- Larry MacDonald - Janitor
- Dylan Ratzlaff - Clare
- Caroline Cave - Isabelle Ainsworth
- Sebastien Roberts - Clark Ainsworth
- Matt Clarke - Desk Clerk
- Randall Hua - Table Attendant
- Ron Robinson - Leader
- Sydney Bell - Joanie
- Rohain Arora - Officer Puri
- David Marshall Grant - Gene Grant
- Teagan Vincze - Joyce
- Jessica St. Clair - Amelia
- Kuba Oms - Joseph
- Bresha Webb - Dr. Jessica Bruno
- David Walton - Colton Cutler
- Shyinne Anastacio - Waitress
- Roraigh Falkner - Young Dad
- Katherine Haysbert - Young Mom
- Justin Singh - Larry
- Eduard Witzke - Attendant
- Lily Yawson - Police Officer
- Dana Gourrier - Melissa
- Jace Fleming - Lars
- Adrian Formosa - Herb
- Nicco Del Rio - Tim
- Ty Barnett - Evan Fisher
- Johanna Braddy - Claire Fisher
- Dwain Murphy - Terrence
- Clare Filipow - Brie
- Andrew McNee - Graham
- Chanelle Peloso - Celeste
- Heather Feeney - Cindee
- Silvana Estifanos - Molly
- Annabelle Loi - Intake Vet Nurse
- Jesse Stretch - Unhoused Man
- Liz Vassey - Dr. Craft
- Thalia Campbell - Daniella
- Nicholas Elia - Jet
- Lisa Huynh - Marie
- Patti Kim - Diane
- Andrew Woo - Male Student
- Tara Pratt - Carol
- Renée Victor - Inez
- Mary-Beth Manning - Councilwoman Dottie Lewis
- Zahf Paroo - Raju Perera
- Cassandra Consiglio - Receptionist
- Jennifer Rose Garcia - April
- Sarah Almonte Peguero - Nurse
- JoBeth Williams - Lana Strobe
- George Wyner - Lonny Strobe
- Christopher Lloyd - Christopher Lloyd
- Chris Robson - Teacher
- Joe Costa - Tyrone
- Robyn Bradley - Sandra
- Sook Hexamer - Elderly Woman
- Linden Banks - Doctor
- Wanda Ayala - Nurse
- Lisa Paxton - School Nurse
- Michael Hogan - Tim
- BJ Harrison - Melinda
- Caitlin Howden - Kirsten
- Kavandeep Hayre - Young Man
- Daniel Bacon - Lukasz / Bartender
- Serge Houde - Captain
- Eric Yue - Man
- Marlene Ginader - Nurse
- Lance Lim - Adult Theo
- Josh Zaharia - Teen Javi
- Agnes Tong - Mishelle Lybell
- Audrey Wise Alvarez - Lana
- Reanna Cameron - Adult Charlie
- Andy Canete - Doctor
- Alia Domino - Nurse
- Marshall Boone
- D.J. Nash
- Aaron Kaplan
- David Marshall Grant
Christopher Lloyd hace el papel de Christopher Lloyd.
Bronson Pinchot interpreta a Berge en la serie.
Marcia Gay Harden interpreta a Alice Mendez en la serie.
Jenny O'Hara interpreta a Enid en la serie.
Melora Hardin interpreta a Patricia en la serie.
Paul Guilfoyle interpreta a Lenny en la serie.
David Giuntoli interpreta a Eddie Saville en la serie.
Romany Malco interpreta a Rome Howard en la serie.
James Roday Rodriguez hace el papel de Gary Mendez.
Christina Moses hace el papel de Regina Howard.
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