- Tina Holmes - Maggie Sibley
- Jeremy Sisto - Billy Chenowith
- Lili Taylor - Lisa Kimmel Fisher
- James Cromwell - George Sibley
- Michele Greene - Dr. Fraker
- Jenna Fischer - Sharon Kinney
- Gabriel Olds - Lauderbach
- Chase Ellison - Young George
- Billy Lush - Paul Duncan
- Abby Brammell - Kirsten
- Daniel Zacapa - Mr. Suarez, Jr.
- Ron Roggé - Smog Check Technician
- Deborah Theaker - Tour Guide
- Ivonne Coll - Vanessa's Therapist
- Molly Hagan - Rachel
- David Shatraw - Shiatsu Client
- W. Earl Brown - Pete
- Roger Velasco - Young Man With Tattoos
- Erica Mer - Courtney
- Amy Hill - Madame Mana Lisa
- Bobby Cannavale - Javier
- Brooke Dillman - Becky
- Judith Hoag - Dawn
- Wendy Schaal - Vickie Dimas
- Glenn Fitzgerald - Aaron Buchbinder
- Matt McCoy - Slick Funeral Director
- Stewart Finlay-McLennan - Connor Thompson
- Leeza Gibbons - Self
- Jordan Ladd - Ginnie
- Nicole Richie - Self
- Dagney Kerr - Patty
- Ricardo Chavira - Ramon
- Caroline Aaron - Amelia
- Jenette Goldstein - Obstetrician
- Alisa Reyes - Julie
- Ken Davitian - Krikor Hovanessian
- Paul Butcher - 5-Year-Old Boy
- Angela Goethals - Cindy
- Beverly Todd - Lucille Charles
- Bill Cobbs - Mr. Jones
- Joel McKinnon Miller - Tuttle Friend with Flattop
- Dina Spybey-Waters - Chatty Mourner
- Vanessa Marano - Tate Pasquese
- Jim Beaver - Prison Officer
- Wade Williams - Paul Kovitch
- Judith Baldwin - Paula Mortimer
- Stanley DeSantis - Peter Burns
- Ellen Albertini Dow - Roberta
- Catherine O'Hara - Carol Ward
- Amy Spanger - Holly Duncan
- Jonathan Tucker - Bruno
- Lois Hall - Minister
- Hansford Rowe - Harold Mossback
- Chris Ellis - Construction Worker #2
- Marc Worden - Zach
- Julianna McCarthy - Beatrice
- Michael Cornacchia - Lawrence Tuttle
- Marty Belafsky - Bakery Worker
- Stephen Snedden - Alternate Son
- Eric Bruskotter - Keith's Partner
- Hal Ozsan - Man in Flower Shop
- Lucinda Jenney - Kenneth's Ex-Wife
- Tara Karsian - 'Dr. Dave' Coordinator
- Jenna Boyd - 7-Year-Old Girl
- Tom Virtue - Edward Gorodetsky
- Veronica Hart - Jean Louise McArthur
- J.G. Hertzler - Gallery Owner
- Dennis Christopher - Kevin Lamb
- Shawn Hatosy - Brody Farrell
- Dean Norris - Detective Shea
- Leon Rippy - Daddy
- Graham Jarvis - Bobo
- Brian Poth - Marc Foster
- Colton James - Josh Feldman
- Julie Brown - Sissy Pasquese
- Anne Ramsay - Jackie Feldman
- Larry Drake - Inspector Gerson
- Raphael Sbarge - Father Clark
- Michael Cudlitz - Dennis, Crossroads Leader
- Travis Wester - Henry
- John Capodice - Tommy Romano
- Sandra Oh - Porn Starlet
- Kim Myers - Dr. Michaelson
- John Billingsley - Boring Man
- Tony Longo - Bitsy
- Adam Rodriguez - Kenny Simms
- Thomas Kopache - Lawrence Mason
- Melissa Paull - Female Bruncher
- Barbara Tarbuck - STD Clinic Doctor
- Lombardo Boyar - Powerful
- Amy Wheaton - Female Student
- Louan Gideon - Grieving Woman
- Matt Ross - Daniel Showalter
- AJ Michalka - Ashley
- Harriet Sansom Harris - Catherine Collins
- Alice Krige - Alma
- Nolan North - Soap Actor
- Ann Cusack - Linda Hoviak
- Chris Messina - Ted Fairwell
- Lisa K. Wyatt - Pam, Kroehner Mortician
- Magda Harout - Anahid's Mother
- Jacob Vargas - Manuel 'Paco' Bolin
- Alexandra Holden - Rebecca Leah 'Becky Maxwell' Milford
- Tuc Watkins - Trevor
- Grant Show - Scott Axelrod
- Christine Estabrook - Emily Previn
- Mary Gross - Floral Instructor
- Robert Foxworth - Dr. Bernard Chenowith
- Terence Knox - Larry Wadd
- James Morrison - Swinger Husband
- Tom Lenk - Young Poet
- Phil Reeves - Stan
- Frank Birney - Walter Kriegenthaler
- Austin Nichols - Kyle
- Kimberlin Brown - Soap Actress
- Molly Parker - Rabbi Ari
- Adam Scott - Ben Cooper
- Evan Handler - Scott Philip Smith
- Lori Alan - Macy's Saleswoman
- Andy Milder - Julio's Principal
- Lee Weaver - James Dubois Marshall
- Stanley Kamel - Death
- Anne Dudek - Allison Williman
- Brian Stepanek - Alex Graham
- Steffani Brass - Michaela
- Elizabeth Rodriguez - Sylvie
- Tracy Middendorf - Adele Swanson
- Caroline Lagerfelt - Alternate Wife
- Bob Morrisey - Dean Kekalos
- Rick Overton - Thomas Sheedy
- Idalis DeLeon - Sophia
- Matt Bradshaw - Porno MP #1
- Joan McMurtrey - Patsy Foster
- Dina Meyer - The Widow
- David Andrews - Michael Piper
- Christina Carlisi - Judy Romano
- Jason Graae - Dennis
- C.J. Sanders - Anthony
- James Pickens Jr. - Roderick Charles
- Chris Pine - Young Sam Hoviak
- Mark Harelik - Leonard
- Kevin Rankin - Johnny
- Jennifer Elise Cox - Mary
- Christina Cabot - Hiking Woman
- Cristine Rose - Hannah
- Nicholas D'Agosto - Jonathan Gorodetsky
- Mena Suvari - Edie
- Kellie Waymire - Melissa
- Brad Greenquist - Building Manager
- Dan Desmond - Art Teacher
- Steve Ryan - Matthew Heath Collins
- Jed Allan - Dr. Gareth Feinberg
- Josh Stamberg - Sarge
- Dave Power - Nolan
- Elaine Kao - Courtney
- Berlinda Tolbert - Debra
- Cleo King - Life
- Mare Winningham - Eileen Piper
- Ted Marcoux - Sam Finelli
- Page Kennedy - Josh Langmead
- Mo Collins - Nancy Freymire
- Diane Delano - Teri
- Arye Gross - Frank Muehler
- Joe Nieves - Construction Worker #1
- Julie White - Mitzi Dalton Huntley
- Jessica D. Stone - Young Brenda
- Lauri Johnson - Joan Morrison
- Robert Pine - Basil
- Stark Sands - Toby
- Mageina Tovah - Pink-Haired Girl
- Patricia Clarkson - Sarah O'Connor
- Lisa Banes - Victoria
- Timothy Landfield - Marv Chenowith
- Sarah Lancaster - Alternate Daughter
- Jennifer Darling - Edie's Mother (voice)
- Rainn Wilson - Arthur Martin
- Amanda Foreman - Rebecca
- Beverly Leech - Mavis Spencer
- Justin Theroux - Joe
- Zachary Quinto - Hip Student
- Silas Weir Mitchell - Dion Corelli
- Mary-Pat Green - Priest
- Lana Parrilla - Maile
- Larry Sullivan - Deputy Wheeler (voice) (uncredited)
- Julie Ariola - Dorothy Milne
- Kathy Bates - Bettina
- Jillian Armenante - Shirley
- Kenneth Kimmins - Crematory Owner
- Gloria Garayua - Agnes
- Erik Stolhanske - Man on Boat
- Lenny Wolpe - Gregory Fasteau
- Ben Weber - Hiking Man
- June Kyoto Lu - Bette Srisal
- Soledad St. Hilaire - Sophia's Neighbor
- Beth Grant - Dorothy Sheedy
- Julia Vera - Cleaning Woman
- Monti Sharp - Clinic Worker
- Eric Balfour - Gabe Dimas
- Michelle Trachtenberg - Celeste
- Nan Martin - Rita Piper
- Elayn J. Taylor - Nurse #1
- Rusty Schwimmer - Marilyn Johnson
- Andrew Prine - Ed Kimmel
- Claudette Sutherland - Cynthia Showalter
- Jayma Mays - Donna
- Kellan Lutz - Critter
- Sean O'Bryan - Tom Wheeler
- Anita Finlay - Female Coke User
- Maury Sterling - Pot Dealer
- Ann Weldon - Aunt Jeanie
- Landry Allbright - Mary Jane
- Jeremy Roberts - Callie's Friend #2
- Kate McGregor-Stewart - Andrea's Therapist
- Jenny O'Hara - Garland Duncan
- Cynthia Stevenson - Joy Solomon
- Ed Begley Jr. - Hiram Gunderson
- Shawn Michael Patrick - Coroner
- Jerry Hauck - Stan
- George Cheung - Mr. Su
- Joel Brooks - Robbie
- Shashawnee Hall - Richard Langmead
- Lee Garlington - Fiona Kleinschmidt
- Cullen Douglas - Mr. Clarington
- Janice Lynde - Loretta Smith Sibley
- Elizabeth Ruscio - Madeleine Burns
- Romy Rosemont - Professor
- Bruce Wright - Detective
- Hallee Hirsh - Kaitlin Stolte
- Sprague Grayden - Anita Miller
- Ethel Ayler - Ellen
- Michael Bell - Quaker Man
- Chris Harrison - Self
- Christopher Neiman - Medvenko
- Terri Hoyos - Realtor
- David Ackert - Truck Driver
- Tamara Taylor - Roger's Lawyer
- Adam Nelson - Match-Lighting Guy
- Illeana Douglas - Angela
- Maggie Baird - Andrea Kuhn
- Margaret Easley - Young Woman in Elevator
- Anna Gunn - Madeline
- Edith Fields - Quaker Woman
- Mark L. Taylor - Mr. Stolte
- Lauren Birkell - Elise
- Victor Campos - Pilar's Father
- Christine Mourad - Coco Gorodetsky
- Carmen Twillie - 'O Happy Day' Singer
- Brooke Smith - Carolyn Pope
- Maura Soden - Mrs. Stolte
- Scott Burkholder - Kenneth Henderson
- Brent Roam - Man in Elevator
- Mary Kathleen Gordon - Wife #6
- Dwayne L. Barnes - Officer Myers
- Jean Carol - Wife #5
- Josh Radnor - Will Jaffe
- Sara Mornell - Jessica Shapiro
- David McSwain - Vet in Wheelchair
- Marina Black - Parisian Classmate
- Paul Hayes - Joe Marti
- John Paul Pitoc - Phil
- Peter Macdissi - Olivier Castro-Staal
- Sarah Rafferty - Rachel Mortimer
- Megan Austin Oberle - Callie Mortimer
- Josette DiCarlo - Sheila
- Paul Cassell - Evan
- Julie Dretzin - Barb
- Michael Weston - Jake
- Anthony Vatsula - Bob Giffen
- Matt Malloy - Roger Pasquese
- Jeff Yagher - Hoyt
- Wilda Taylor - Ramona Kippleman
- Ellen DeGeneres - Ellen DeGeneres
- Brandon Dean - Eric
- Joanna Cassidy - Margaret Chenowith
- Ben Scott - Butcher
- Christi Lake - Porno Girl
- Peter Facinelli - Jimmy
- Leyna Weber - Dee Dee
- Rachel Zeskind - Nate's Ex-Girlfriend (uncredited)
- Lee Wesley - Adult Anthony (uncredited)
- Hayden Thompson - Singing Kd #3 (uncredited)
- Alan Poul - Wedding Guest (uncredited)
- Ricardo Mamood-Vega - Hospital Orderly (uncredited)
- Franceska Lynne - Bridesmaid (uncredited)
- Amanda Leighton - Singing Cactus Kid (uncredited)
- Toby Holguin - Armored Truck Robber (uncredited)
- Armando Guerrero - Older Rico (uncredited)
- Mark Durbin - Daniel Nathanson - Brenda's Husband (uncredited)
- Gwendolyn Druyor - Bridesmaid (uncredited)
- Jennifer Griffin - Crying Sicilian Daughter
- Audrey Gelfund - Crying Sicilian Mother
- Dennis Lau - Morgue Attendant
- Maximillian Kesmodel - Young David
- Harper Roisman - Elderly Man
- Dennis Anderson - Market Clerk
- Hayden Tank - Young Nate
- Sharon Madden - Woman Mourner
- Gary Hershberger - Kroehner Representative
- Van Epperson - Angry Man
- Danielle Petty - Waitress (uncredited)
- Hunter Johnson - Mandy Gorodetsky
- Brett Paesel - Dominique
- Rosalind Chao - Cindy
- David Janollari
- Kate Robin
- Scott Buck
- Alan Poul
- Alan Ball
- Robert Del Valle
Rick Overton interpreta a Thomas Sheedy en la serie.
Ellen DeGeneres hace el papel de Ellen DeGeneres.
Harriet Sansom Harris hace el papel de Catherine Collins.
Lili Taylor hace el papel de Lisa Kimmel Fisher.
Stanley DeSantis interpreta a Peter Burns en la serie.
Joanna Cassidy interpreta a Margaret Chenowith en la serie.
Dina Meyer interpreta a The Widow en la serie.
Caroline Aaron hace el papel de Amelia.
Adam Nelson interpreta a Match-Lighting Guy en la serie.
Jenny O'Hara hace el papel de Garland Duncan.
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