- Ajai Sanders - Gina Devereaux
- Karen Malina White - Charmaine Brown
- Jada Pinkett Smith - Lena James
- Sinbad - Coach Walter Oakes
- Marisa Tomei - Maggie Lauten
- Mary Alice - Lettie Bostic
- Loretta Devine - Stevie Rallen
- Bridgid Coulter - Bettina
- Joe Morton - Byron Douglas III
- Ted Ross - Dean Harris
- Rosalind Cash - Dean Hughes
- Roxanne Beckford - Courtney
- Tisha Campbell - Josie Webb
- T.K. Carter - Darnell Gaines
- David Alan Grier - Professor Byron Walcott
- Kenneth Washington - Mercer Gilbert
- Gerrit Graham - Henry Krum
- Sharon Brown - Angela
- Larry Linville - Sen. Hutchinson
- John Marshall Jones - Otis Curtis
- Halle Berry - Jaclyn
- Carlos Lacámara - Waiter
- Tempestt Bledsoe - Vanessa Huxtable
- Mary Testa - Waitress
- Clyde Kusatsu - Kinishiwa Representative
- Damon Wayans - Marvin Haven
- Monica Calhoun - Yolanda
- Lisa Canning - Girl
- Brad Johnson - Mr. Wess
- Ahmad Rashād - Dr. Zander
- Blair Underwood - Zelmer Collier
- Theresa Randle - Elizabeth James
- Earle Hyman - Russel Huxtable
- Alaina Reed Hall - Claims Officer #5
- Tom Alan Robbins - Club Host
- Victor Love - Lionel Walker
- Cliff Emmich - Desk Sergeant
- Ernie Sabella - Campus Policeman
- Jana Marie Hupp - Lennox Baylor
- Phylicia Rashād - Clair Huxtable
- Ann Weldon - Velma Gaines
- Sister Souljah - Ianta
- Denise Nicholas - Carol Garrison
- Eriq La Salle - Professor Paul Mann
- Malcolm-Jamal Warner - Theo Huxtable
- Jaime Cardriche - Winston 'The Meat Locker' Woodson
- Kim Wayans - Allison
- Gilbert Gottfried - Sergeant
- Kelly Jo Minter - Charisse
- Roscoe Lee Browne - Dr. Barnabus Foster
- Michael Ensign - Auctioneer
- Khandi Alexander - Theressa Stone
- Shaun Baker - Champ
- Alex Désert - Livingston
- Dean Cain - Eddie
- Peter Jason - Mr. Schmect
- Bill Cosby - Heathcliff Huxtable
- Tamara Taylor - Dwayne's Date
- Dean Howell - Michael
- Allen Payne - Lance Rodman
- LaRita Shelby - Leslie Wilkins
- Alfonso Ribeiro - Zach Duncan
- Joseph C. Phillips - Martin Kendall
- Vanessa Bell Calloway - Lily Connors
- Vanessa Bell Calloway - Danielle Vinson
- Edafe Blackmon - Tutor
- Edafe Blackmon - Dion
- Tanya Boyd - Col. Taylor's Former Student
- Juanita Jennings - Desk Sergeant
- Rick Barry - Self
- Tom Arnold - Looter
- Gretchen Palmer - Tammy
- Marie-Alise Recasner - Millie
- Duane Davis - Derek
- Richard Roundtree - Clinton Reese
- Barbara Montgomery - Imogene Douglas
- Mark Clayman - Steve
- Troy Byer - Monica
- Phill Lewis - Sam Lee
- Rif Hutton - Security #2
- Keshia Knight Pulliam - Rudy Huxtable
- Tupac Shakur - Piccolo
- Robert Hooks - Phillip Dalton
- Marjean Holden - Nikki
- Orlando Jones - Troy Douglas
- Raven-Symoné - Olivia Kendall
- Michael Warren - Reverend Soams
- Roseanne Barr - Looter
- Vernee Watson-Johnson - Carla Meyers
- Lee Weaver - Ray Nay
- Stanley Brock - Santa Claus
- Josef Powell - Shane Wayne
- Paul Benedict - Mr. Ludlow
- Howard Dell - Phil
- Ja'net DuBois - Brenda Hanes
- Frantz Turner - Marcus Anderson
- Candy Ann Brown - Professor Burton
- CJ Jones - CJ
- Pillow - Self
- Roger Guenveur Smith - Prof. Howard Randolph
- T.J. Evans - Alex Webb
- Toy Newkirk - Bianca
- George C. Simms - Ernie Miles
- Leroy Edwards III - Tony
- Bradley Mott - Lou
- Marius Mazmanian - Andre
- Cleavant Derricks - Larry
- Wynonna Smith - Lorna
- K. Todd Freeman - Novian Winters
- LaVerne Anderson - Priscilla
- Whoopi Goldberg - Dr. Jordan
- Art Evans - Mr. Johnson
- Roxie Roker - Dean Barksdale
- Andrew Lowery - Matthew
- Kiki Shepard - Dr. Sutherland
- Kiki Shepard - Vanna Black
- Michael Milhoan - Fireman
- Beverly Todd - Julia Reeves
- Michael Ralph - Spencer Boyer
- Michael Ralph - Clint
- Michael Ralph - Frank
- Michael Ralph - Tyrone
- Michael Ralph - Don
- Jenifer Lewis - Dean Dorothy Dandridge Davenport
- Jenifer Lewis - Susan Clayton
- Dominic Hoffman - Julian Day
- Dominic Hoffman - Kent Souje
- Julius Carry - Larry Beaujolais
- Josephine Premice - Desiree Porter
- Josephine Premice - Erdine Abernathy
- Debbi Morgan - Lisa Westin
- Jake Carpenter - Rick
- Trina McGee - Gennifer
- Robert Guillaume - Dean Winston
- Robert Guillaume - Prof. Murphy
- Ron Canada - Grover James
- Leonard Lightfoot - Ted Selman
- Nigel Gibbs - Officer
- Lisa Marie Russell - Tricia
- Cynthia L. James - Amber Waves
- Cory Tyler - Terrence Taylor
- Rondell Sheridan - Looter
- Kenneth Mars - Ridley
- Jeanine Jackson - Melissa Brulay
- Brandon Quintin Adams - Dion
- Brandon Quintin Adams - Tino
- Clinton Jackson - Steve Rocklin
- Tom Wright - John Holtworth
- Al Fann - Diner Employee
- Al Fann - Sgt. Herndon Carruthers
- Montel Williams - Self
- Nestor Carbonell - Malik Velasquez
- Carol Ann Susi - Desk Sergeant
- Ronald William Lawrence - Loco
- Gary Dourdan - Shazza Zulu
- Anita Morris - Joni Brooks
- Tamara Clatterbuck - Grace
- Marcia Wallace - Waitress
- Marla Gibbs - Principal Shaw
- Lena Horne - Self
- Billy Dee Williams - Langston Paige
- Marques Houston - Eli Black
- Young Rome - Crayton Adams
- Chante Carmel - Iesha
- Ahmad Stoner - Olufemi Dakar
- Aries Spears - Ty
- Leslie Uggams - Dr. Eileen Redding
- Eartha Robinson - Libby Hall Step Captain
- Eartha Robinson - Loretta
- Eartha Robinson - Theressa's Friend
- Juan Pope - Guy
- Reginald Ballard - Guy #2
- Diahann Carroll - Marion Gilbert
- Patti LaBelle - Adele Wayne
- Harold Sylvester - Woodson Wayne
- Bebe Drake - Velma Gaines
- Bumper Robinson - Dorian Heywood
- Debbie Allen - Dr. Langhorne
- Debbie Allen - Debbie Allen (uncredited)
- Patrick Malone - Terrell Walker
- Keenen Ivory Wayans - Professor Lawrence
- Bee-Be Smith - Gloria
- Todd Hallowell - Cooper
- Terry Ellis - [En Vogue]
- Cindy Herron - [En Vogue]
- Chris 'Mac Daddy' Kelly - Self [Kris Kross]
- Chris 'Daddy Mac' Smith - Self [Kris Kross]
- Galyn Görg - Monica Gilbert
- Galyn Görg - Melissa Swazey
- Jermaine Dupri - Deejay
- Conroy Gedeon - Mercer Gilbert
- Kristoff St. John - E.Z. Brooks
- Katie Rich - Cougar
- Gladys Knight - Herself
- Taimak - Garth Parks
- Jesse Jackson - Himself
- Raymond St. Jacques - Prof. Charles Moseley
- Ron O'Neal - Mercer Gilbert
- Ron O'Neal - Quentin
- Heavy D - Himself
- Obba Babatundé - Frank Benning
- Rueben Grundy - Ernest Bennett
- Leila Danette - Ms. Pruitt
- Maurice Davis - Randall Adams
- Elizabeth Narvaez - Kara
- Pierre Manasse - Waiter
- Don Reed - Chip St. Charles
- Mayah McCoy - Kelly
- John Ashley Hamilton - Dr. Settle
- Damon Whitaker - Ron's Barber
- Lalanya Masters - Eva
- Viva Vinson - Janetta
- James Avery - The Pin Punisher
- Kimble Jemison - Nerdy Student
- Kimble Jemison - Cadet
- Norman Nixon - Norm
- Aaron Seville - Little Brother Humpty
- Aaron Seville - Guy
- Albert Hall - Chaplain
- Peggy Mannix - Nurse
- Wren T. Brown - Milt
- John H. Francis - William Shakespeare
- Peggy Walton-Walker - Amy
- Ann Hearn - Manager
- Joseph Michael Roth - Jewelry Store Clerk (uncredited)
- Suli McCullough - Clarence Peele (uncredited)
- Nancy Black - Woman
- Tony Burton - Cap Connors
- Jeanne Carr - Bartender
- Senait Ashenafi - Rachael Johnson
- Kevin Hunter - Ricardo
- Sam Vlahos - Mr. Santos
- Jane Singer - Woman
- Charlayne Woodard - Paramedic
- Maxine Jones - [En Vogue]
- Dawn Robinson - [En Vogue]
- Stephanie Williams - Barbara
- Michael D. Jones - Hillman College Student (uncredited)
- Lewis Dix Jr. - Kim's Dance Partner
- Lewis Dix Jr. - Earl Rabney
- Aryana Starr - Dashawn Curtis
- Thomas Hobson - Boy
- Ron Robinson - Antonio
- Michael Caldwell - Cop
- Carey Eidel - Store Manager
- Graham Timbes - Shopper
- Janet Borrus - Beverly Hills Looter
- Judy Nazemetz - Beverly Hills Looter
- Vince Howard - Peacemaker
- Wesley Jonathan - South Central Looter
- Kathleen Wirt - Beverly Hills Looter
- Billy Kane - Murphy
- Lacy Darryl Phillips - Singer
- Peter Koch - Cop
- Stacy Arnell - Lacey
- Annie Korzen - Customer
- Jeri Gray - Tutor
- Marquise Wilson - Ron Jackson Jr.
- Amir Williams - J.T. Rallen
- Reggie Johnson - Michael Oku
- Arthur Adams - Dr. Cordell Overby
- Guy Killum - Virgil
- Paris Vaughan - Colette
- Claudette Wells - Peggy Harley
- Jeff Williams - Mark
- Julia Waters - Backup Singer
- Julia Waters - Dancer
- Maxine Waters Willard - Dancer
- Maxine Waters Willard - Backup Singer
- Zakes Mokae - Marcus Mpepo
- Oren Waters - Dancer
- Oren Waters - John Wayne
- Kenneth Ransom - Rick Evans
- Alice Arthur - Girl
- Matthew Dickens - Guy
- Matthew Dickens - Airport Employee
- A.J. Johnson - Girl
- Loretta Chandler - Girl
- Jill Ito - Hostess
- Diane Almeida - Madeleine
- Luise Heath - Dr. Mason
- Frank Renzulli - Enrico
- Eugene Williams - Frat Guy
- Don Barnes - Guy
- Michael DeLorenzo - Ramon Duarte
- Vincent Craig Dupree - Jerk at Bar
- Michael Whaley - Guy
- Terrence Williams - Byron
- Terrence Williams - Boy
- Terrence Williams - Dancer
- Theo Forsett - Ernie
- Thomas Mikal Ford - Lamar Collins
- Joe Costanza - Waiter
- Reed R. McCants - Chuck Lance
- Stephanie Pope - Girl
- Steven E. Daniels - Paul
- Susan Fales-Hill - Mandy
- Gian-Carlo Scandiuzzi - Waiter
- Paulette Braxton - Ron's Date
- Wayne A. King - Mover
- Scott Williamson - Jim Howell
- Linda Hoy - Waitress
- Linda Hoy - News Anchor
- Randy Kaplan - Bill
- Aydiee Vaughn - Alpha Delta Rho Pledge
- Aydiee Vaughn - Girl
- Yvette Holland Vasquez - Shelby Walters
- Edgar Godineaux - Braxton Brother
- Jonathan Webb - Braxton Brother
- Von Washington - Bruce Murphy
- Kevin Hicks - Reggie
- Steve Sheridan - Guy
- Wayne Federman - A
- Adam Gifford - Ticket Scalper
- Richard Murphy - J.C.
- Luisa Leschin - Ms. Lopez
- Fitz Houston - Grieving Customer
- Anne Gee Byrd - Maude Mitchell
- Adia Joëlle - Wedding Guest
- Tom Werner
- Debbie Allen
Marisa Tomei interpreta a Maggie Lauten en la serie.
Whoopi Goldberg hace el papel de Dr. Jordan.
Joe Morton interpreta a Byron Douglas III en la serie.
Lisa Bonet interpreta a Denise Huxtable en la serie.
Lee Weaver interpreta a Ray Nay en la serie.
Billy Dee Williams interpreta a Langston Paige en la serie.
Halle Berry interpreta a Jaclyn en la serie.
Theresa Randle interpreta a Elizabeth James en la serie.
Jasmine Guy interpreta a Whitley Marion Gilbert en la serie.
Kadeem Hardison interpreta a Dwayne Cleophus Wayne en la serie.
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