- Liam Neeson - Self
- Arnold Schwarzenegger - Self
- Al Pacino - Self
- Penélope Cruz - Self
- Morgan Freeman - Self
- Cillian Murphy - Self
- Anderson Cooper - Self
- Sharyn Alfonsi - Self
- Scott Pelley - Self
- Prince Mohammed bin Salman al Saud - Self
- Pope Francis - Self
- Hassan Rouhani - Self
- Joel Sartore - Self
- Greg Skomal - Self
- Jamal Khashoggi - Self (archival footage)
- Hubert H. Humphrey - Self
- Malcolm Muggeridge - Self
- Peter von Zahn - Self
- Luigi Barzini - Self
- Ramsey Clark - Self
- Rex Tillerson - Self
- Brett Kavanaugh - Self (archive footage)
- Kamala Harris - Self
- Viola Davis - Self
- Shakira - Self
- Muriel Bowser - Self
- Simone Biles - Self
- Francis Collins - Self
- Jill Biden - Self
- Bernie Sanders - Self
- Michael Bloomberg - Self
- Medaria Arradondo - Self
- Joaquin Phoenix - Self
- George W. Bush - Self
- Howard Schultz - Self
- L. Jon Wertheim - Self
- Andrew McCabe - Self
- Nancy Pelosi - Self
- Jerome Powell - Self
- Ryan Speedo Green - Self
- Alexandria Ocasio-Cortez - Self
- Massimo Bottura - Self
- Oprah Winfrey - Self
- Jennifer Lawrence - Self
- Mahmoud Ahmadinejad - Self
- Clarence Thomas - Self
- Bruce Springsteen - Self
- Valerie Plame - Self
- Nicolas Sarkozy - Self
- LaDainian Tomlinson - Self
- Alex Rodriguez - Self
- Pervez Musharraf - Self
- Roger Clemens - Self
- Gustavo Dudamel - Self
- Dennis Quaid - Self
- Antonin Scalia - Self
- Jon Bon Jovi - Self
- Bob Woodward - Self
- John McCain - Self
- Henry Paulson - Self
- T. Boone Pickens - Self
- Ted Turner - Self
- Michelle Obama - Self
- Chris Martin - Self
- Jon Buckland - Self
- Will Champion - Self
- Guy Berryman - Self
- Dolly Parton - Self
- Robert Gates - Self
- Anna Wintour - Self
- Kim Zimmer - Self
- Beth Chamberlin - Self
- Ron Raines - Self
- Marc Dreier - Self
- Andre Agassi - Self
- Richard Nixon - Self
- Mike Pence - Self
- Elon Musk - Self
- Bashar Hafez al-Assad - Self
- Barack Obama - Self
- Donald Trump - Self
- Hillary Clinton - Self
- David McCullough - Self
- Lady Gaga - Self
- Joe Biden - Self
- Angus King - Self (archive footage)
- Susan Collins - Self
- John Dingell - Self (archive footage)
- Rafael Nadal - Self - Tennis Player
- Cecilia Vega - Self
- John R. Bolton - Self
- Novak Djokovic - Self
- Holly Williams - Self
- Morley Safer - Self
- Lesley Stahl - Self
- John Dickerson - Self
- Alan K. Simpson - Self (archive footage)
- James Corden - Self
- Norah O'Donnell - Self
- Steve Kroft - Self
- Mike Wallace - Self
- Ed Bradley - Self
- Andrew Rooney - Self
- Lara Logan - Self
Liam Neeson interpreta a Self en la serie.
Arnold Schwarzenegger interpreta a Self en la serie.
Al Pacino hace el papel de Self.
Penélope Cruz interpreta a Self en la serie.
Morgan Freeman hace el papel de Self.
Cillian Murphy hace el papel de Self.
Bill Whitaker interpreta a Self en la serie.
Anderson Cooper hace el papel de Self.
Sharyn Alfonsi hace el papel de Self.
Scott Pelley interpreta a Self en la serie.
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