- Starla Benford - Ultrasound Nurse
- Jessica Hecht - Rebecca Ellis
- Steve Braun - Otis Wills
- Maggie Siff - Lisa Ketchum
- Griffin Dunne - Dr. Jerry Cole
- Benjamin Walker - Nick Ross
- Kate Jennings Grant - Kristen Lund
- Celia Weston - Tilly Bates
- Ashlie Atkinson - Nurse Rhonda
- Cyrus Farmer - Isaiah
- Julia Campbell - Roberta Mack
- Madeline Zima - Cassie Mack
- Juliette Goglia - Erica Linden
- Tamara Taylor - Della
- Cynthia Nixon - Dr. Karin Hanson
- Karl Bury - Matt Ketchum
- Nick Offerman - Dr. Coffey
- Jennifer Ferrin - Penny Marx
- Gloria Garayua - Lucy Canet
- Petrea Burchard - O.R. Nurse
- Addison Timlin - Charlotte Hanson
- Molly Bryant - Nurse Joanne
- Cristin Milioti - Megan Rafferty
- Ned Eisenberg - Brad Ellis
- Eleanor Seigler - Nurse Melissa
- Max Arciniega - Jose
- Liz Burnette - Anesthesiologist
- Anna George - Helen Clark
- Jack Gilpin - Dr. Wardell
- Jerzy Gwiazdowski - Male Student
- Linda Kuriloff - Kathleen
- Wrenn Schmidt - Female Student
- Sibyl Santiago - Nurse (uncredited)
- Peter Ocko
- Scott Kaufer
- Barry M. Berg
Griffin Dunne interpreta a Dr. Jerry Cole en la serie.
Celia Weston interpreta a Tilly Bates en la serie.
Stanley Tucci interpreta a Douglas Hanson en la serie.
Mark Feuerstein interpreta a Jonathan Seger en la serie.
Indira Varma interpreta a Adrianne Holland en la serie.
Armando Riesco interpreta a Tom Flores en la serie.
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