- Wyatt Nash - Tad
- Miguel Sandoval - Enrique Desoto
- Carlos Lacámara - Panamanian President
- Jose Yenque - President of Colombia
- Paula Newsome - Atlanta Weaver
- Mary Pat Gleason - Patty
- Jay Leno - Jay Leno
- Ella Rouhier - Adorable Girl
- Chic Daniel - Secret Service Agent
- John Eddins - Secret Service Agent Mike
- Juan Carlos Cantu - Argentinian President
- Robert Covarrubias - Ecuadorian President
- Angela Elayne Gibbs - HHS Secretary
- Clint Culp - Burly Boom Guy
- Parker Croft - Mike
- Karan Soni - Misfit
- Adam Shapiro - Evan
- Maria Breese - Reporter
- Willie C. Carpenter - General Maurer
- Peter Jason - General Harrigan
- Mika Brzezinski - Mika Brzezinski
- Joe Scarborough - Joe Scarborough
- Willie Geist - Willie Geist
- Misty Monroe - Reporter
- Staci Lawrence - Casey
- Stacy Keach - Frohm Thoroughgood
- Susan Park - Stacey Kim
- Constance Towers - Bunny Thoroughgood
- Savannah Guthrie - Savannah Guthrie
- Steve Seagren - Mailroom Supervisor
- Sean Hamrin - Thoroughgood's Aide
- Blair Hickey - Onlooker
- Jennifer Christopher - Onlooker
- Brett Chapin - Mr. Murphy
- René Auberjonois - Winslow Hannum
- Robbie Amell - D.B.
- Rebecca Wisocky - Bianca
- David St. James - Klaus
- Adam Kaiz - Steward
- Mayank Bhatter - Mahmoud
- Missi Pyle - Sarah Harlan
- Jane Edith Wilson - Mrs. Stitchcomb
- Danika Yarosh - Jessica
- Dave Anthony - Mark
- Janet Hoskins - Protester
- Lano Medina - Protester
- Ryan Raddatz - Protester
- Elijah Nelson - Misfit
- Jovan Armand - Student
- Bruce Campbell - Doug Gilchrist
- Rob Benedict - Skeptic
- Mary Hart - Mary Hart
- Rory O'Malley - Tour Guide
- Nadège August - Vanessa
- Lou Richards - Cabinet Secretary
- Laurent Schwaar - Head Chef
- Chuck Todd - Chuck Todd
- Boo Arnold - Secret Service Agent Terry
- Darlene Kardon - Reporter
- Tim Bagley - Mr. Norgel
- Sapna Gandhi - Press Aide
- Sapna Gandhi - Staffer
- Lucia Vecchio - Kayla
- Marilyn Zack - Midwestern Tourist
- Matt Corboy - Tommy
- Jon Donahue - NSC Geek
- Randy Bautista - NSC Geek
- Henry Winkler - Senator Faxler
- Matt Price - Congressman Shapiro
- Tom Wright - Interviewer
- Alexis Wolfe - Staffer
- Oscar Magana Jr. - Larry King Crew Member
- Tom Amandes - Bernard
- Sofia Milos - Bernice
- Rafael J. Noble - Lou Berryman
- Hannah Simone - Princess Abigail
- Pete Gardner - Pete
- Nancy Cheryll Davis - Hillary
- Maura Soden - Madeline
- Andy Favreau - John
- D.C. Pierson - Casanova
- Larry King - Larry King
- Christine Avila - Millie Garcia
- Shaan Sharma - Old Navy Manager
- Tim Scanlon - Secret Service Agent
- Jason Winer
- Mike Royce
- Jon Lovett
Missi Pyle interpreta a Sarah Harlan en la serie.
Stacy Keach interpreta a Frohm Thoroughgood en la serie.
David St. James interpreta a Klaus en la serie.
Josh Gad hace el papel de Skip Gilchrist.
Bill Pullman hace el papel de President Dale Gilchrist.
Jenna Elfman hace el papel de Emily Nash Gilchrist.
Martha MacIsaac interpreta a Becca Gilchrist en la serie.
André Holland hace el papel de Marshall Malloy.
Amara Miller hace el papel de Marigold Gilchrist.
Benjamin Stockham hace el papel de Xander Gilchrist.
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