- Rebel Wilson - Brynn
- Matt Lucas - Gil
- Michael Hitchcock - Don Cholodecki
- Tim Heidecker - Douglas Price
- Franklyn Ajaye - Mr. Donovan
- Lynne Marie Stewart - Mrs. Donovan
- Terry Crews - Rodney
- Jessica St. Clair - Whitney
- Kali Hawk - Kahlua
- Andy Buckley - Helen's Husband
- Matt Bennett - Helen's Stepson
- Nancy Carell - Helen's Tennis Partner
- Melanie Hutsell - Carol
- Carnie Wilson - Carnie Wilson
- Chynna Phillips - Chynna Phillips
- Wendy Wilson - Wendy Wilson
- Joe Nuñez - Oscar
- Mia Rose Frampton - Jewelry Store Girl
- Tom Yi - Jewelry Store Couple
- Elaine Kao - Jewelry Store Couple
- Mitch Silpa - Flight Attendant Steve
- Dana Powell - Flight Attendant Claire
- Greg Tuculescu - Kevin
- Brian Petsos - Pete
- Ben Falcone - Air Marshall Jon
- Richard Riehle - Bill Cozbi
- Suzanne LaChasse - Hostess (uncredited)
- Annie Mumolo - Nervous Woman on Plane
- Jillian Bell - Girl at Shower
- Ariane Price - Girl at Shower
- Paul Feig - Wedding Guest (uncredited)
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Frédéric Sojcher
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