- Elizabeth Debicki - Emperor Haban-Limaï (voice)
- Sam Spruell - General Okto Bar
- Ola Rapace - Major Gibson
- Alain Chabat - Bob the Pirate
- Thom Findlay - Pirates (voice)
- Mathieu Kassovitz - Hawker
- Aymeline Valade - Emperor Haban-Limaï
- Sasha Luss - Princess Lïhio-Minaa / Creature 'Candy Dress'
- Pauline Hoarau - Empress Aloï / Creature 'Swing Angel'
- Jonas Bloquet - K-Tron Warrior / Control Room Soldier
- Sand Van Roy - Creature 'Jessica Rabbit'
- Louis Leterrier - Captain Welcoming Mercurys
- Olivier Megaton - Captain Welcoming KCO2
- Sam Douglas - Male Tourist
- Diva Sicard - Mâatri (Tsûuri's Friend)
- Eric Lampaert - Guide Thaziit
- Alexandre Willaume - Captain Kris
- Gavin Drea - Sergent Cooper
- Réginal Kudiwu - Major Samk
- David Michie - Pearl Tsuuri (voice)
- Marion Roussignol - Pearl
- Emilie Pommelet - Pearl
- Roman Blomme - Boulan Bathor
- Emilie Livingston - Bubble Dancer (as Emilie Goldblum)
- Alexandre Nguyen - Japanese Delegate
- Aurelien Gaya - Igon Sirus Guard
- Mikael Buxton - Paradise Alley Soldier
- Yun Lai - Valley Chinois
- Anders Heinrichsen - Police Officer
- Tristan Robin - Roper
- Yun-Ping He - Controller of the Technical Chamber
- David Clark - Astronaut
- Ben Mauro - Commander Arün Filitt Guard
- Jean-François Lenogue - Igon Sirus Guard
- Peter Eberst - Igon Sirus Guard
- Xavier Giannoli - Captain Norton
- Eric Rochant - Captain Welcoming Palm Müret
- Benoît Jacquot - Captain Welcoming Arysum
- Gérard Krawczyk - Captain Welcoming Martapuraïs
- Pierre Cachia - Kortan Dahük
- David Saada - Kortan Dahük
- Hippolyte Burkhart-Uhlen - Kortan Dahük
- Florian Guichard - Mercury
- Stéphane Mir - Mercury
- Thierry Barthe - Mercury
- Pier Ewudu - Palm Müret
- Andrew Tisba - Palm Müret
- Yannick Lorté - Palm Müret
- Charly Akakpo - Arysum-Kormn
- Clément Beauruelle - Arysum-Kormn
- Audrey Kamp - Arysum-Kormn
- Anthony Hornez - Martapuraï
- Julien Bleitrach - Martapuraï
- Maxime Babara Touré - Martapuraï
- Barbara Weber-Scaff - Empress Aloï (voice)
- Marilhéa Peillard - Tsûuri
- Lee Delong - Tsûuri / Tourist (voice)
- Judith Brunett - Mâatri (Tsûuri's Friend) (voice)
- Marie Barrouillet - Tsûuri Child
- Cindy Bruna - Guard
- Sija Titko - Guard
- Daphnée Kbidi - Tortured Pearl
- Nick Marzock - Tortured Pearl (voice)
- Stefan Konarske - Captain Zito
- Mahamadou Coulibaly - Major Gibon's Soldier / Igon Junio
- Julien Marlin - Major Gibon's Soldier
- Yvan Lucker - Major Gibon's Soldier
- Tom Hygreck - Major Gibon's Soldier
- Abel Jafri - Bus Driver
- Laurent Ferraro - Igon Siruss / Doghan Dagui
- Jean-Robert Lombard - Igon Sirus Guard
- Leonid Glushchenko - Igon Sirus Guard
- Akim Chir - Igon Sirus Guard
- Laminé Ba - Igon Sirus Guard
- Paul Lefèvre - Siirt Guard / Siirt Salesman
- Guillaume Maison - Siirt Salesman
- Jean-Christophe Brizard - Siirt Salesman
- Patrick Cottet-Moine - Siirt Cop
- Irene Palko - Female Tourist
- James Flynn - Guide #2
- Tonio Descanvelle - DA / Doghan-Dagui
- Velvet D'Amour - Tourist
- Doug Rand - Doghan-Dagui
- Grant Moninger - Doghan-Dagui (voice)
- Robbie Rist - Doghan-Dagui (voice)
- Christopher Swindel - Doghan-Dagui (voice)
- Claire Tran - Bubble / Glamopod / Control Room Sergeant
- Alain Etoundi - Club Bouncer
- Fayet Nsumoto - Club Bouncer
- Kristina Kachinskaya - Creature 'Twin'
- Veronika Khayla - Creature 'Twin'
- Sissi Duparc - Creature 'Louis XVI'
- Noam Frost - Creature 'Bird Woman'
- Pauline Serreau - Creature 'Tattoo'
- Philippe Rigot - Hero Merchant
- Étienne Ménard - Red Zone Captain
- Peter Lamarque - Warship Captain
- Maximilien Seweryn - K-Tron Captain
- Zouheir Zerhouni - K-Tron Warrior
- Tristan Zerbib - K-Tron Warrior
- Elliot Jenicot - Interrogation Room Captain
- Staiv Gentis - Control Room Soldier
- Chloé Hollings - Alex-Intruder's Voice (voice)
- Aguendia Fotabong - Boulan Bathor Emperor
- Tania Dessources - Boulan Bathor Emperor's Wife
- Gaëtan Cotigny - Fisherman
- François Bredon - Fisherman
- Peter Hudson - Captain Crowford
- Cédric Chevalme - Bubble / Boulan-Bathor / Valerian
- David Clark - Astronaut (uncredited)
- Benjamin Cléry - Boulan Bathor (uncredited)
- Luc Besson
- Louise Molière
- Emmanuelle Fourault
- Stéphane Gluck
- Luc Besson
- Pierre Christin
- Jean-Claude Mézières
- Luc Besson
- Nathalie Chéron
- Virginie Besson-Silla
- Mateo Guez
- Claude Varis
- Alexandre Desplat
- David Farmer
- Juan Peralta
- Conrad Pope
- Didier Lozahic
- Didier Lozahic
Capítulo disponible en las siguientes plataformas:
