- Embeth Davidtz - Mary Parker
- Chris Zylka - Flash Thompson
- C. Thomas Howell - Jack's Father
- Jake Keiffer - Jack
- Hannah Marks - Missy Kallenback
- Kari Coleman - Helen Stacy
- Michael Barra - Store Clerk
- Leif Gantvoort - Cash Register Thief
- Andy Pessoa - Gordon
- Kelsey Asbille - Sally Avril
- Kevin McCorkle - Mr. Cramer
- Ring Hendricks-Tellefsen - Physics Nerd
- Barbara Eve Harris - Miss Ritter
- Danielle Burgio - Nicky's Girlfriend
- Tom Waite - Nicky
- Steve DeCastro - Car Thief Cop
- Jill Flint - Receptionist
- Mark Daugherty - OsCorp Intern
- Milton González - Rodrigo Guevara
- Skyler Gisondo - Howard Stacy
- Charlie DePew - Philip Stacy
- Jacob Rodier - Simon Stacy
- Vincent Laresca - Construction Worker
- Damien Lemon - Taxi Driver
- Ty Upshaw - Police Officer with Sketch
- James Chen - Police Officer
- Alexander Bedria - Officer (SWAT)
- Tia Texada - Sheila (Subway)
- John Burke - Newscaster (News Chopper)
- Terry Bozeman - Principal
- Jennifer Lyons - Second Girl (Subway)
- Michael Massee - Gustav Fiers
- Amber Stevens West - Ariel
- Max Bogner - Scientist (uncredited)
- Ethan Cohn - Lab Technician (uncredited)
- Miles Elliot - Billy Connors (uncredited)
- Miranda LaDawn Hill - Cheerleader (uncredited)
- Amanda MacDonald - Goth Girl (uncredited)
- Maury Morgan - Tina (uncredited)
- Michael Papajohn - Alfie (uncredited)
- Marc Webb
- Stan Lee
- Steve Ditko
- Alvin Sargent
- Francine Maisler
- Matt Tolmach
- Kevin Feige
- Avi Arad
- David Giammarco
- Robin Harlan
- Paul Massey
- James Horner
- Dean Andre
- Robert Edwards
Capítulo disponible en las siguientes plataformas:
