- James Cosmo - Renton's Father
- Steven Robertson - Stoddart
- John Kazek - Tom (Rehab Group)
- Gordon Kennedy - Tulloch
- Tereza Duskova - Tourism Girl
- Elek Kish - Dozo
- Lewis Gribben - Dealer
- Simon Weir - Jailhouse
- Katie Leung - Nurse
- Atta Yaqub - Medical Student
- Christopher Douglas - Chris the Oracle
- James McElvar - Simon (aged 20)
- Bryan Quinn - Man in Music Video
- Tom Urie - Big Bear
- John Bell - Spud (aged 20)
- Kyle Fitzpatrick - Fergus
- Eileen Nicholas - Renton's Mother
- Kevin McKidd - Tommy
- Amy Manson - Woman in Club
- Nebli Basani - Hardman
- Pauline Lynch - Lizzy
- Svetla Yancheva - Veronika's Mother
- Blair Flucker - Club Patron (uncredited)
- Adam James Johnston - Club Patron (uncredited)
- David Gilchrist
- Michael Queen
- Harry Boyd
- John Hodge
- Gail Stevens
- Irvine Welsh
- Rebecca Farhall
- Allon Reich
- Danny Boyle
- Andrew Macdonald
- Emilie O'Connor
- Niv Adiri
- Glen Gathard
- Glenn Freemantle
- Peter Burgis
- Chris Navarro
Capítulo disponible en las siguientes plataformas: