- Chevy Chase - Self
- Louis C.K. - Self
- Ellen Cleghorne - Self
- Bradley Cooper - Self / Craig Kristofferson
- Billy Crystal - Self
- Jane Curtin - Self / Weekend Update Anchor
- Miley Cyrus - Self
- Pete Davidson - Self
- Robert De Niro - Self
- Michael Douglas - Self
- Rachel Dratch - Self / Debbie Downer
- Jimmy Fallon - Self
- Will Ferrell - Self / Alex Trebek / Marty Culp
- Will Forte - Self / Greg Stink
- James Franco - Self
- Zach Galifianakis - Self
- Ana Gasteyer - Self / Bobbi Culp
- John Goodman - Self
- Bill Hader - Self / Devin / Stefon
- Darrell Hammond - Self - Announcer (voice) / Sean Connery
- Tom Hanks - Self
- Derek Jeter - Self
- Dakota Johnson - Self
- Leslie Jones - Self
- Taran Killam - Self / Christoph Waltz / Tyler
- Jon Lovitz - Self
- Norm Macdonald - Self / Burt Reynolds
- Peyton Manning - Self
- Paul McCartney - Self
- Steve Martin - Self / King Tut
- Melissa McCarthy - Self / Matt Foley
- Kate McKinnon - Self / Justin Bieber
- Tim Meadows - Self
- Garrett Morris - Self
- Bobby Moynihan - Self / Land Shark
- Eddie Murphy - Self
- Bill Murray - Self / Nick Ocean
- Mike Myers - Self / Wayne Campbell
- Kevin Nealon - Self
- Laraine Newman - Self / Super Bass-O-Matic 2150 Model / Karina's Mom
- Jack Nicholson - Self
- Edward Norton - Self / Stefon
- Bob Odenkirk - Self
- Sarah Palin - Self
- Joe Piscopo - Self / Frank Sinatra
- Amy Poehler - Self / Weekend Update Anchor
- Colin Quinn - Self
- Keith Richards - Self
- Chris Rock - Self
- Maya Rudolph - Self / Beyoncé
- Jerry Seinfeld - Self
- Paul Shaffer - Self
- Adam Sandler - Self / Opera Man
- Molly Shannon - Self / Mary Katherine Gallagher
- Martin Short - Self
- Paul Simon - Self
- David Spade - Self / Total Bastard Airlines Flight Attendant
- Emma Stone - Self / Roseanne Roseannadanna
- Cecily Strong - Self / Total Bastard Airlines Flight Attendant / Piper
- Jason Sudeikis - Self / Vance / Pete Twinkle
- Taylor Swift - Self / Allison
- Kenan Thompson - Self / Bill Cosby / Trey / Diondre Cole
- Justin Timberlake - Self
- Kanye West - Self
- Kerry Washington - Self / Dr. Julianne Richards
- Betty White - Self / Lana
- Kristen Wiig - Self / Karina / Kat
- Jan Hooks - Self - Cast Member (In Memoriam)
- Andy Kaufman - Self - Guest Performer (In Memoriam)
- Danitra Vance - Self - Cast Member (In Memoriam)
- Charles Rocket - Self - Cast Member (In Memoriam)
- Phil Hartman - Self - Cast Member (In Memoriam)
- Chris Farley - Self - Cast Member (In Memoriam)
- Michael O'Donoghue - Self - Writer / Performer (In Memoriam)
- John Belushi - Self - Cast Member (In Memoriam)
- Gilda Radner - Self - Cast Member (In Memoriam)
- Ty Dolla Sign - Self
- Aidy Bryant - Self
- Brian Doyle-Murray - Self
- Kevin Hart - Self
- Siobhan Fallon Hogan - Self
- Colin Jost - Self
- Eli Manning - Self
- Vic Mensa - Self
- Cheri Oteri - Self
- Jay Pharoah - Self
- Geoffrey Beevers - Congressman
- Horatio Sanz - Self
- Sia - Self
- Christopher Walken - Self
- Jack White - Self
- Sasheer Zamata - Self / Pippa
- Catherine Zeta-Jones - Self
- Don Roy King
- Tina Fey
- Jeff Richmond
- Marc Shaiman
- Erik Kenward
- Paula Pell
- Sarah Schneider
- Lorne Michaels
- Steve Higgins
- Rhys Thomas
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