- Kimiko Gelman - May Lee Ha (segment "Happy Birthday")
- Jean Kasem - Nurse (segment "Happy Birthday")
- Taylor Negron - Policeman (segment "Happy Birthday")
- Travis Wester - Chute Boy (segment "Happy Birthday")
- Dondré Whitfield - Man in Elevator (segment "Happy Birthday")
- Marissa Jaret Winokur - Dean's Secretary (segment "Happy Birthday")
- Bruce Davison - (segment "The Other Side")
- Anthony LaPaglia - Dr. Maas (segment "The Other Side")
- Karen Sillas - Anna (segment "The Other Side")
- Andie MacDowell - Lisa (segment "Reaching Normal")
- Paul Rudd - Kenneth (segment "Reaching Normal")
- Joey Lauren Adams - Sarah (segment "Reaching Normal")
- Alan Rosenberg - Frank (segment "Reaching Normal")
- Joel Grey - Dr. Mensley (segment "Reaching Normal")
- Jolene Blalock - Charlie's Wife (wraparound segments)
- Scott Lowell - Charlie (wraparound segments)
- Stephen Tobolowsky - Tom (wraparound segments)
- Kathleen Wilhoite - Lucy (wraparound segments)
- Ellen DeGeneres - Operator (segment "Reaching Normal") (uncredited)
- Helen Mirren
- Anne Heche
- Mary Stuart Masterson
-
Jana Sue Memel
- Jim Goodwin
Capítulo disponible en las siguientes plataformas:
