- Udo Kier - Hans
- Carrie Brownstein - Suzanne
- Sunny Suljic - Skateboarder #2
- Cree Kawa - Skateboarder #3
- Nolan Gross - Skateboarder #4
- Emilio Rivera - Jesus Alvarado
- Angelique Rivera - Terry Alvarado
- Rebecca Rittenhouse - Bonnie
- Anne Lane - Virginia
- Jessica Jade Andres - Cindy
- Torian Miller - Car Attendant
- Rebecca Field - Margie Bighew
- Olivia Hamilton - Nurse Lilly
- Peter Banifaz - Doctor Mirione
- Alexandra W.B. Malick - Older Nurse
- Kyle Dunnigan - Ward Doctor
- Santina Muha - Debbie
- Christopher Thornton - Charles-Marie
- Joseph Baken - Editor #3
- Ron Perkins - Mr. Katz
- Heather Matarazzo - Shannon
- Michael Chow - PSU Teacher
- Ryan Meharry - Police Office #1
- Cathy Fielding - Bakery Woman
- John Bishop - Cowboy Wino
- Ronnie Clark - Wino One
- Jonathan Erickson Eisley - Junior Wino
- Betsy Sodaro - Powell's Information Person
- Jedediah Jones - Felix - AA Member #1
- Lou Wilson - Joseph - AA Member #2
- Ayden Mayeri - Brenda
- Nick Rutherford - Drinker
- Ramy Youssef - Drinker
- Robby Rasmussen - Levon - Man on Bike
- Helen Slayton-Hughes - Woman on Bus
- Ethan Michael Mora - Young John Callahan
- Mireille Enos - John's Ghost Mom
- Connor Skific - Cowboy
- Kelli McNeil-Yellen - Woman with Dog
- Steve Zissis - Elias (uncredited)
- Jaret Martino - Booth Operator (uncredited)
- Scott Robertson
- Gus Van Sant
- John Callahan
- Francine Maisler
- Steve Golin
- Charles-Marie Anthonioz
- Danny Elfman
Capítulo disponible en las siguientes plataformas:
