- Mike Tyson - Mike Tyson
- Henry G. Sanders - Martin
- Pedro Lovell - Spider Rico
- Ana Gerena - Isabel
- Louis Giansante - Bar Thug
- Maureen Schilling - Lucky's Bartender
- Lahmard J. Tate - X-Cell
- Woody Paige - ESPN Commentator
- Skip Bayless - ESPN Commentator
- Jay Crawford - ESPN Commentator
- Brian Kenny - ESPN Host
- Dana Jacobson - ESPN Host
- Charles Johnson - ESPN Host
- James Binns - Commissioner
- Johnnie Hobbs Jr. - Commissioner
- Barney Fitzpatrick - Commissioner
- Jim Lampley - HBO Commentator
- Larry Merchant - HBO Commentator
- Max Kellerman - HBO Commentator
- LeRoy Neiman - LeRoy Neiman
- Bert Sugar - Ring Magazine Reporter
- Bernardo Fernández - Boxing Association of America Writer
- Gunnar Peterson - Weightlifting Trainer
- Yahya - Dixon's Opponent
- Marc Ratner - Weigh-In Official
- Anthony Lato Jr. - Rocky's Inspector
- Jack Lazzarado - Dixon's Inspector
- Michael Buffer - Ring Announcer
- Joe Cortez - Referee
- Carter Mitchell - Shamrock Foreman
- Vinod Kumar - Ravi
- Fran Pultro - Father at Restaurant
- Frank Stallone Jr. - Dinner Patron
- Jody Giambelluca - Dinner Patron
- Tobias Segal - Robert's Friend
- Tim Carr - Robert's Friend
- Matt Frack - Robert's Friend #3
- Paul Dion Monte - Robert's Friend
- Kevin King Templeton - Robert's Friend
- Robert Michael Kelly - Mr. Tomilson
- Rick Buchborn - Rocky Fan
- Nick Baker - Irish Pub Bartender
- Don Sherman - Andy
- Stu Nahan - Computer Fight Commentator (voice)
- Gary Compton - Security Guard
- David Gere - Patron at Adrian's (uncredited)
- Jacob 'Stitch' Duran - Stitch (uncredited)
- Talia Shire - Adrianna "Adrian" Balboa (Archive Footage)
- Burgess Meredith - Micky Goldmill (Archive Footage)
- Angelyna Martinez-Boyd - Angie
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Mauro Borrelli
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Danielle Masters, Kevin DeWalt, Wesley Snipes
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