- Dorothy Tree - Martha Rockne
- Johnny Sheffield - Knute - Age 7
- Nick Lukats - Harry Stuhldreher - One of The Four Horsemen
- Kane Richmond - Elmer Laydon - One of The Four Horsemn
- William Marshall - Don Miller - One of The Four Horsemen
- William Byrne - James Crowley - One of The Four Horsemen
- Howard Jones - USC Coach Howard Jones
- William 'Bill' Spaulding - Bill Spaulding
- Erville Alderson - Kansas Farmer Witnessing Airplane Crash (uncredited)
- Rudolph Anders - Elder in Norway (uncredited)
- Peter Ashley - Football Player (uncredited)
- Tommy Baker - Newsboy (uncredited)
- Georgie Billings - Boy Quarterback (uncredited)
- Wade Boteler - Trainer (uncredited)
- Egon Brecher - Elder in Norway (uncredited)
- David Bruce - Reporter When Knute is Ill (uncredited)
- Cliff Clark - Danny - Post Office Paymaster (uncredited)
- Richard Clayton - O'Flaherty - a Student (uncredited)
- Frank Coghlan Jr. - Messenger (uncredited)
- Joe Cunningham - Reporter on Train (uncredited)
- Donald Curtis - West Point Football Player (uncredited)
- Billy Dawson - Knute Rockne Jr. - Age 12 (uncredited)
- Edgar Dearing - Doc - Knute's Friend at Kansas City Airport (uncredited)
- Dudley Dickerson - Train Porter (uncredited)
- David Dickinson - Bill Rockne - Age 10 (uncredited)
- Lucile Fairbanks - Telephone Operator (uncredited)
- James Flavin - Army Assistant Coach (uncredited)
- John Gallaudet - Notre Dame Coach Harper (uncredited)
- Peter B. Good - Bill 'Billy' Rockne - Age 2 (uncredited)
- Sol Gorss - Man Wheeling Knute's Wheelchair (uncredited)
- Creighton Hale - Callahan's Secretary (uncredited)
- Harry Harvey Jr. - Boy (uncredited)
- Michael Harvey - Football Player (uncredited)
- Harry Hayden - Committee Member (uncredited)
- George Haywood - Student (uncredited)
- Oscar 'Dutch' Hendrian - Assistant Coach Hunk Anderson (uncredited)
- William Hopper - New York Reporter When Knute is Ill (uncredited)
- George Irving - Doc - a Notre Dame Professor (uncredited)
- Danny Jackson - Boy (uncredited)
- Dickie Jones - Boy Captain (uncredited)
- Brian Keith - Student at Train Station (uncredited)
- Owen King - Western Union Clerk in Kansas City (uncredited)
- Marilyn Kinsley - Bathing Beauty (uncredited)
- Lois Lindsay - Bathing Beauty (uncredited)
- Carlyle Moore Jr. - Player Eating Bonnie's Chicken (uncredited)
- Paul Panzer - Extra at Train Station (uncredited)
- Steve Pendleton - Football Player #12 (uncredited)
- Lee Phelps - Army Coach (uncredited)
- George Reeves - Distraught Player (uncredited)
- Sam Rice - Extra at Committee Hearing (uncredited)
- Ruth Robinson - Molly - Gipp's Mother (uncredited)
- Jeffrey Sayre - Jeff - Reporter on Train (uncredited)
- Billy Sheffield - Knute Rockne - Age 4 (uncredited)
- Edwin Stanley - Committee Member (uncredited)
- Ruth Tobey - Isobel (uncredited)
- Charles Trowbridge - Professor (uncredited)
- Frederick Vogeding - Elder in Norway (uncredited)
- David Wade - Knute Rockne - Age 7 (uncredited)
- Pierre Watkin - Commissioner at Hearing (uncredited)
- Garry Watson - Boy (uncredited)
- Charles C. Wilson - Gambler (uncredited)
- Robert Winkler - Tommy (uncredited)
- Jack Wise - Football Fan at Game (uncredited)
- Maris Wrixon - Telephone Operator (uncredited)
- Lloyd Bacon
- Robert Buckner
- Jack L. Warner
- Hal B. Wallis
- Leo F. Forbstein
- Ray Heindorf
Pat O’Brien interpreta a Knute Rockne en la película.
Gale Page interpreta a Bonnie Skiles Rockne en la película.
Ronald Reagan interpreta a George Gipp en la película.
Donald Crisp interpreta a Father John Callahan, C.S.C en la película.
Albert Bassermann interpreta a Father Julius Nieuwland en la película.
John Litel interpreta a Committee Chairman en la película.
Henry O'Neill hace el papel de Doctor.
Owen Davis Jr. interpreta a Gus Dorais en la película.
John Qualen hace el papel de Lars Knutson Rockne.
Dorothy Tree interpreta a Martha Rockne en la película.
Johnny Sheffield interpreta a Knute - Age 7 en la película.
Nick Lukats hace el papel de Harry Stuhldreher - One of The Four Horsemen.
Kane Richmond interpreta a Elmer Laydon - One of The Four Horsemn en la película.
William Marshall interpreta a Don Miller - One of The Four Horsemen en la película.
William Byrne interpreta a James Crowley - One of The Four Horsemen en la película.
Howard Jones interpreta a USC Coach Howard Jones en la película.
Glenn 'Pop' Warner hace el papel de Coach 'Pop' Warner.
Amos Alonzo Stagg interpreta a Coach Alonzo Stagg en la película.
William 'Bill' Spaulding interpreta a Bill Spaulding en la película.
Erville Alderson hace el papel de Kansas Farmer Witnessing Airplane Crash (uncredited).
Rudolph Anders interpreta a Elder in Norway (uncredited) en la película.
Peter Ashley interpreta a Football Player (uncredited) en la película.
Evelyn Atchinson hace el papel de Bathing Beauty (uncredited).
Tommy Baker interpreta a Newsboy (uncredited) en la película.
Jack Banta interpreta a Punter (uncredited) en la película.
Tommy Bennett interpreta a O'Reilly (uncredited) en la película.
Georgie Billings interpreta a Boy Quarterback (uncredited) en la película.
Wade Boteler interpreta a Trainer (uncredited) en la película.
Egon Brecher hace el papel de Elder in Norway (uncredited).
David Bruce hace el papel de Reporter When Knute is Ill (uncredited).
Cliff Clark interpreta a Danny - Post Office Paymaster (uncredited) en la película.
Richard Clayton hace el papel de O'Flaherty - a Student (uncredited).
Frank Coghlan Jr. hace el papel de Messenger (uncredited).
Joe Cunningham hace el papel de Reporter on Train (uncredited).
Donald Curtis interpreta a West Point Football Player (uncredited) en la película.
Billy Dawson interpreta a Knute Rockne Jr. - Age 12 (uncredited) en la película.
Edgar Dearing interpreta a Doc - Knute's Friend at Kansas City Airport (uncredited) en la película.
Dudley Dickerson interpreta a Train Porter (uncredited) en la película.
David Dickinson interpreta a Bill Rockne - Age 10 (uncredited) en la película.
Lucile Fairbanks hace el papel de Telephone Operator (uncredited).
James Flavin hace el papel de Army Assistant Coach (uncredited).
Bunky Fleischman interpreta a Bill Rockne - Age 5 (uncredited) en la película.
John Gallaudet interpreta a Notre Dame Coach Harper (uncredited) en la película.
Peter B. Good interpreta a Bill 'Billy' Rockne - Age 2 (uncredited) en la película.
Sol Gorss interpreta a Man Wheeling Knute's Wheelchair (uncredited) en la película.
Jack Grant Jr. hace el papel de Bill Rockne - Age 14 (uncredited).
Billy Gratton interpreta a Jackie Rockne - Age 4 (uncredited) en la película.
Creighton Hale hace el papel de Callahan's Secretary (uncredited).
Harry Harvey Jr. interpreta a Boy (uncredited) en la película.
Michael Harvey interpreta a Football Player (uncredited) en la película.
Harry Hayden hace el papel de Committee Member (uncredited).
Patricia Hayes interpreta a Jeannie Rockne - Age 10 (uncredited) en la película.
George Haywood hace el papel de Student (uncredited).
Oscar 'Dutch' Hendrian interpreta a Assistant Coach Hunk Anderson (uncredited) en la película.
William Hopper interpreta a New York Reporter When Knute is Ill (uncredited) en la película.
George Irving interpreta a Doc - a Notre Dame Professor (uncredited) en la película.
Danny Jackson interpreta a Boy (uncredited) en la película.
Lois James interpreta a Bathing Beauty (uncredited) en la película.
Dickie Jones interpreta a Boy Captain (uncredited) en la película.
Brian Keith interpreta a Student at Train Station (uncredited) en la película.
Owen King hace el papel de Western Union Clerk in Kansas City (uncredited).
Marilyn Kinsley interpreta a Bathing Beauty (uncredited) en la película.
Lois Lindsay hace el papel de Bathing Beauty (uncredited).
Pete Mehringer hace el papel de Football Player (uncredited).
Carlyle Moore Jr. hace el papel de Player Eating Bonnie's Chicken (uncredited).
Paul Panzer hace el papel de Extra at Train Station (uncredited).
Steve Pendleton interpreta a Football Player #12 (uncredited) en la película.
Lee Phelps interpreta a Army Coach (uncredited) en la película.
George Reeves interpreta a Distraught Player (uncredited) en la película.
Sam Rice interpreta a Extra at Committee Hearing (uncredited) en la película.
Ruth Robinson interpreta a Molly - Gipp's Mother (uncredited) en la película.
Jeffrey Sayre interpreta a Jeff - Reporter on Train (uncredited) en la película.
Billy Sheffield hace el papel de Knute Rockne - Age 4 (uncredited).
Edwin Stanley interpreta a Committee Member (uncredited) en la película.
Phil Thorpe hace el papel de Boy Center (uncredited).
Ruth Tobey interpreta a Isobel (uncredited) en la película.
Charles Trowbridge interpreta a Professor (uncredited) en la película.
Frederick Vogeding hace el papel de Elder in Norway (uncredited).
David Wade hace el papel de Knute Rockne - Age 7 (uncredited).
Pierre Watkin interpreta a Commissioner at Hearing (uncredited) en la película.
Garry Watson interpreta a Boy (uncredited) en la película.
Charles C. Wilson hace el papel de Gambler (uncredited).
Robert Winkler interpreta a Tommy (uncredited) en la película.
Jack Wise interpreta a Football Fan at Game (uncredited) en la película.
Maris Wrixon interpreta a Telephone Operator (uncredited) en la película.
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