- Dorothy Tree - Martha Rockne
- Johnny Sheffield - Knute - Age 7
- Nick Lukats - Harry Stuhldreher - One of The Four Horsemen
- Kane Richmond - Elmer Laydon - One of The Four Horsemn
- William Marshall - Don Miller - One of The Four Horsemen
- William Byrne - James Crowley - One of The Four Horsemen
- Howard Jones - USC Coach Howard Jones
- William 'Bill' Spaulding - Bill Spaulding
- Erville Alderson - Kansas Farmer Witnessing Airplane Crash (uncredited)
- Rudolph Anders - Elder in Norway (uncredited)
- Peter Ashley - Football Player (uncredited)
- Tommy Baker - Newsboy (uncredited)
- Georgie Billings - Boy Quarterback (uncredited)
- Wade Boteler - Trainer (uncredited)
- Egon Brecher - Elder in Norway (uncredited)
- David Bruce - Reporter When Knute is Ill (uncredited)
- Cliff Clark - Danny - Post Office Paymaster (uncredited)
- Richard Clayton - O'Flaherty - a Student (uncredited)
- Frank Coghlan Jr. - Messenger (uncredited)
- Joe Cunningham - Reporter on Train (uncredited)
- Donald Curtis - West Point Football Player (uncredited)
- Billy Dawson - Knute Rockne Jr. - Age 12 (uncredited)
- Edgar Dearing - Doc - Knute's Friend at Kansas City Airport (uncredited)
- Dudley Dickerson - Train Porter (uncredited)
- David Dickinson - Bill Rockne - Age 10 (uncredited)
- Lucile Fairbanks - Telephone Operator (uncredited)
- James Flavin - Army Assistant Coach (uncredited)
- John Gallaudet - Notre Dame Coach Harper (uncredited)
- Peter B. Good - Bill 'Billy' Rockne - Age 2 (uncredited)
- Sol Gorss - Man Wheeling Knute's Wheelchair (uncredited)
- Creighton Hale - Callahan's Secretary (uncredited)
- Harry Harvey Jr. - Boy (uncredited)
- Michael Harvey - Football Player (uncredited)
- Harry Hayden - Committee Member (uncredited)
- George Haywood - Student (uncredited)
- Oscar 'Dutch' Hendrian - Assistant Coach Hunk Anderson (uncredited)
- William Hopper - New York Reporter When Knute is Ill (uncredited)
- George Irving - Doc - a Notre Dame Professor (uncredited)
- Danny Jackson - Boy (uncredited)
- Dickie Jones - Boy Captain (uncredited)
- Brian Keith - Student at Train Station (uncredited)
- Owen King - Western Union Clerk in Kansas City (uncredited)
- Marilyn Kinsley - Bathing Beauty (uncredited)
- Lois Lindsay - Bathing Beauty (uncredited)
- Carlyle Moore Jr. - Player Eating Bonnie's Chicken (uncredited)
- Paul Panzer - Extra at Train Station (uncredited)
- Steve Pendleton - Football Player #12 (uncredited)
- Lee Phelps - Army Coach (uncredited)
- George Reeves - Distraught Player (uncredited)
- Sam Rice - Extra at Committee Hearing (uncredited)
- Ruth Robinson - Molly - Gipp's Mother (uncredited)
- Jeffrey Sayre - Jeff - Reporter on Train (uncredited)
- Billy Sheffield - Knute Rockne - Age 4 (uncredited)
- Edwin Stanley - Committee Member (uncredited)
- Ruth Tobey - Isobel (uncredited)
- Charles Trowbridge - Professor (uncredited)
- Frederick Vogeding - Elder in Norway (uncredited)
- David Wade - Knute Rockne - Age 7 (uncredited)
- Pierre Watkin - Commissioner at Hearing (uncredited)
- Garry Watson - Boy (uncredited)
- Charles C. Wilson - Gambler (uncredited)
- Robert Winkler - Tommy (uncredited)
- Jack Wise - Football Fan at Game (uncredited)
- Maris Wrixon - Telephone Operator (uncredited)
- Lloyd Bacon
- Robert Buckner
- Jack L. Warner
- Hal B. Wallis
- Leo F. Forbstein
- Ray Heindorf
Pat O’Brien interpreta a Knute Rockne en la película.
Gale Page hace el papel de Bonnie Skiles Rockne.
Ronald Reagan hace el papel de George Gipp.
Donald Crisp hace el papel de Father John Callahan, C.S.C.
Albert Bassermann hace el papel de Father Julius Nieuwland.
John Litel hace el papel de Committee Chairman.
Henry O'Neill interpreta a Doctor en la película.
Owen Davis Jr. interpreta a Gus Dorais en la película.
John Qualen interpreta a Lars Knutson Rockne en la película.
Dorothy Tree hace el papel de Martha Rockne.
Johnny Sheffield interpreta a Knute - Age 7 en la película.
Nick Lukats hace el papel de Harry Stuhldreher - One of The Four Horsemen.
Kane Richmond hace el papel de Elmer Laydon - One of The Four Horsemn.
William Marshall hace el papel de Don Miller - One of The Four Horsemen.
William Byrne hace el papel de James Crowley - One of The Four Horsemen.
Howard Jones hace el papel de USC Coach Howard Jones.
Glenn 'Pop' Warner interpreta a Coach 'Pop' Warner en la película.
Amos Alonzo Stagg interpreta a Coach Alonzo Stagg en la película.
William 'Bill' Spaulding interpreta a Bill Spaulding en la película.
Erville Alderson interpreta a Kansas Farmer Witnessing Airplane Crash (uncredited) en la película.
Rudolph Anders interpreta a Elder in Norway (uncredited) en la película.
Peter Ashley interpreta a Football Player (uncredited) en la película.
Evelyn Atchinson hace el papel de Bathing Beauty (uncredited).
Tommy Baker hace el papel de Newsboy (uncredited).
Jack Banta interpreta a Punter (uncredited) en la película.
Tommy Bennett interpreta a O'Reilly (uncredited) en la película.
Georgie Billings interpreta a Boy Quarterback (uncredited) en la película.
Wade Boteler interpreta a Trainer (uncredited) en la película.
Egon Brecher interpreta a Elder in Norway (uncredited) en la película.
David Bruce interpreta a Reporter When Knute is Ill (uncredited) en la película.
Cliff Clark hace el papel de Danny - Post Office Paymaster (uncredited).
Richard Clayton interpreta a O'Flaherty - a Student (uncredited) en la película.
Frank Coghlan Jr. interpreta a Messenger (uncredited) en la película.
Joe Cunningham hace el papel de Reporter on Train (uncredited).
Donald Curtis interpreta a West Point Football Player (uncredited) en la película.
Billy Dawson hace el papel de Knute Rockne Jr. - Age 12 (uncredited).
Edgar Dearing hace el papel de Doc - Knute's Friend at Kansas City Airport (uncredited).
Dudley Dickerson hace el papel de Train Porter (uncredited).
David Dickinson interpreta a Bill Rockne - Age 10 (uncredited) en la película.
Lucile Fairbanks interpreta a Telephone Operator (uncredited) en la película.
James Flavin hace el papel de Army Assistant Coach (uncredited).
Bunky Fleischman interpreta a Bill Rockne - Age 5 (uncredited) en la película.
John Gallaudet interpreta a Notre Dame Coach Harper (uncredited) en la película.
Peter B. Good interpreta a Bill 'Billy' Rockne - Age 2 (uncredited) en la película.
Sol Gorss interpreta a Man Wheeling Knute's Wheelchair (uncredited) en la película.
Jack Grant Jr. hace el papel de Bill Rockne - Age 14 (uncredited).
Billy Gratton interpreta a Jackie Rockne - Age 4 (uncredited) en la película.
Creighton Hale interpreta a Callahan's Secretary (uncredited) en la película.
Harry Harvey Jr. interpreta a Boy (uncredited) en la película.
Michael Harvey hace el papel de Football Player (uncredited).
Harry Hayden hace el papel de Committee Member (uncredited).
Patricia Hayes interpreta a Jeannie Rockne - Age 10 (uncredited) en la película.
George Haywood interpreta a Student (uncredited) en la película.
Oscar 'Dutch' Hendrian interpreta a Assistant Coach Hunk Anderson (uncredited) en la película.
William Hopper hace el papel de New York Reporter When Knute is Ill (uncredited).
George Irving interpreta a Doc - a Notre Dame Professor (uncredited) en la película.
Danny Jackson interpreta a Boy (uncredited) en la película.
Lois James hace el papel de Bathing Beauty (uncredited).
Dickie Jones interpreta a Boy Captain (uncredited) en la película.
Brian Keith interpreta a Student at Train Station (uncredited) en la película.
Owen King hace el papel de Western Union Clerk in Kansas City (uncredited).
Marilyn Kinsley interpreta a Bathing Beauty (uncredited) en la película.
Lois Lindsay interpreta a Bathing Beauty (uncredited) en la película.
Pete Mehringer interpreta a Football Player (uncredited) en la película.
Carlyle Moore Jr. interpreta a Player Eating Bonnie's Chicken (uncredited) en la película.
Paul Panzer interpreta a Extra at Train Station (uncredited) en la película.
Steve Pendleton interpreta a Football Player #12 (uncredited) en la película.
Lee Phelps hace el papel de Army Coach (uncredited).
George Reeves interpreta a Distraught Player (uncredited) en la película.
Sam Rice interpreta a Extra at Committee Hearing (uncredited) en la película.
Ruth Robinson hace el papel de Molly - Gipp's Mother (uncredited).
Jeffrey Sayre interpreta a Jeff - Reporter on Train (uncredited) en la película.
Billy Sheffield interpreta a Knute Rockne - Age 4 (uncredited) en la película.
Edwin Stanley interpreta a Committee Member (uncredited) en la película.
Phil Thorpe hace el papel de Boy Center (uncredited).
Ruth Tobey interpreta a Isobel (uncredited) en la película.
Charles Trowbridge interpreta a Professor (uncredited) en la película.
Frederick Vogeding interpreta a Elder in Norway (uncredited) en la película.
David Wade hace el papel de Knute Rockne - Age 7 (uncredited).
Pierre Watkin interpreta a Commissioner at Hearing (uncredited) en la película.
Garry Watson hace el papel de Boy (uncredited).
Charles C. Wilson hace el papel de Gambler (uncredited).
Robert Winkler hace el papel de Tommy (uncredited).
Jack Wise interpreta a Football Fan at Game (uncredited) en la película.
Maris Wrixon interpreta a Telephone Operator (uncredited) en la película.
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