- Sean Young - Marie Barth
- Crispin Glover - Howard Barth
- Roseanne Barr - Madame Zoe
- Buck Henry - Dr. Dreyfus
- Grace Zabriskie - Mrs. Hankshaw
- Treva Jeffryes - Young Sissy
- Ken Kesey - Sissy's Daddy
- Ken Babbs - Sissy's Uncle
- Allen Arnold - Lionel
- Victoria Williams - Cowgirl Debbie
- Heather Graham - Cowgirl Heather
- Judy Robinson - Cowgirl Gloria
- Betsy Roth - Cowgirl Mary
- Arlene Wewa - Big Red
- Heather Hershey - Cowgirl Donna
- Dee Fowler - Cowgirl Kym
- Udo Kier - Commercial Director
- Wade Evans - Cameraman
- Tom Peterson - Crewman
- Alexa D'Avalon - Rubber Rose Bird Expert
- Eric Hull - White House Undersecretary
- Oliver Kirk - Sheriff
- Joe Ivy - FBI Director
- Greg McMickle - FBI Agent
- Lin Shaye - Rubber Rose Maid
- Chel White - Brain Surgeon
- Molly Little - Salsa Singer
- Scott Patrick Green - Pilgrim Man
- Suzanne Solgot - Pilgrim Woman
- Michael Parker - Pilgrim Driver
- William S. Burroughs - Self
- Sherry Alps - Cowgirl
- Eliza Butterfly - Cowgirl
- Boo Connolly - Cowgirl
- Christie Flenniken - Cowgirl
- Stacey Hyder - Cowgirl
- Tina Knaggs - Cowgirl
- Tom Robbins - Narrator (voice)
- Roger Bowen - Naturalist (uncredited)
- Edward James Olmos - Musician at Barbecue (uncredited)
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Perry Martin
-
Perry Martin
Capítulo disponible en las siguientes plataformas: