- Jemaine Clement - Dr. Ian Garvin
- Giovanni Ribisi - Parker Selfridge
- Britain Dalton - Lo'ak
- Jamie Flatters - Neteyam
- Trinity Bliss - Tuktirey 'Tuk'
- Jack Champion - Miles 'Spider' Socorro
- Brendan Cowell - Mick Scoresby
- Bailey Bass - Tsireya
- Filip Geljo - Aonung
- Duane Evans Jr. - Rotxo
- Dileep Rao - Dr. Max Patel
- Matt Gerald - Recom Wainfleet
- Robert Okumu - Ta'unui Olecthan
- Jennifer Stafford - Ta'unui Tsahik
- Keston John - Tarsem
- Kevin Dorman - Recom Mansk
- Alicia Vela-Bailey - Recom Zdinarsik
- Sean Anthony Moran - Recom Fike
- Andrew Arrabito - Recom Prager
- Johnny Alexander - Recom Ja
- Kim Do - Recom Zhang
- Victor T. Lopez - Recom Lopez
- Maria Walker - Recom Walker
- Phil Brown - Stringer
- Jocelyn Christian - Bio Lab Tech
- Joel Tobeck - Neuroscientist
- Moana Ete - Female Med-Tech
- Phil Peleton - Male Med-Tech
- Jamie Landau - Metkayina Warrior
- Jim Moore - Mako Sub #1 Pilot
- Benjamin Hoetjes - Mako Sub #1 Gunner
- Nikita Tu Bryant - Mako Sub #2 Pilot
- Anthony Ahern - Mako Sub #2 Gunner
- Shane Rangi - Matador Co-Pilot
- Rick Lucas - Kestrel Pilot
- Tanya Drewery - Neurotech #1
- Ava Diakhaby - Neurotech #2
- Isaac Te Reina - Sea Dragon First Mate
- Eric Farmer - Crabsuit Pilot
- Philip Mtambo - Skel Trooper
- Daniel Lough - Spider Double
- Cruz Moir - Young Spider
- Alex Lucas - Toddler Spider
- Scarlett Fernandez - Young Kiri
- Chloe Coleman - Young Lo'ak
- Jeremy Irwin - Young Neteyam
- Jake McLean - Na'vi (uncredited)
- CJ Jones - Metkayina Interpreter (uncredited)
Capítulo disponible en las siguientes plataformas: