- Channing Tatum - Duke
- Arnold Vosloo - Zartan
- Marlon Wayans - Ripcord
- Dennis Quaid - General Hawk
- Grégory Fitoussi - Baron de Cobray
- Leo Howard - Young Snake Eyes
- Karolína Kurková - Cover Girl
- David Murray - James McCullen - 1641
- Kevin J. O'Connor - Doctor Mindbender
- Gerald Okamura - Hard Master
- Brandon Soo Hoo - Young Storm Shadow
- Christopher Akers - G.I. Joe Security Tech
- Michael Benyaer - Flight Control Technician
- Peter Breitmayer - Dr. Hundtkinder
- Michael Broderick - Screaming Man
- Elena Evangelo - White House Staff
- Jacques Frantz - Bastille Prison Warden
- Wayne Lopez - G.I. Joe Security Tech
- Kellie Matteson - G.I. Joe Control Room Technician
- Burton Perez - Bravo Soldier
- Bob Rumnock - M.A.R.S. Lab Worker
- Robert Russell - Bastille Prison Priest
- Ashley Sommers - Little Girl
- Gunner Wright - Secret Service Agent
- Duncan Bravo - Foreign General
- Charles Howerton - Foreign General
- David Jean Thomas - Foreign General
- Ken Thomas - Apache Navigator
- Frederic Doss - Apache Navigator
- Ron Thompson - Apache Helicopter Pilot
- Brendan Fraser - Sgt. Stone (uncredited)
- Larry Hama - NATO General (uncredited)
-
Stephen Sommers
- David Elliot
- Stuart Beattie
- Cliff Lanning
- Erik Howsam
- Stephen Sommers
- Nancy Bishop
- Lorenzo di Bonaventura
- Matthew Stuecken
- Alan Silvestri
- Karen Baker Landers
- Peter Staubli
- Scott Millan
- Hector C. Gika
- Dino DiMuro
Capítulo disponible en las siguientes plataformas:
