- Paul Bettany - Jarvis (voice)
- William Sadler - President Ellis
- Dale Dickey - Mrs. Davis
- Ty Simpkins - Harley Keener
- Miguel Ferrer - Vice President Rodriguez
- Wang Xueqi - Doctor Wu
- Shaun Toub - Ho Yinsen
- Matthew Sterling Nye - Annoying Conference Guy
- Pat Kiernan - Pat Kiernan
- Josh Elliott - Josh Elliott
- Megan Henderson - Megan Henderson
- Thomas Roberts - Thomas Roberts
- Bill Maher - Bill Maher
- Joan Rivers - Joan Rivers
- George Kotsiopoulos - George Kotsiopoulos
- Bronte D'Esposito - Neptune's Net Girl
- Noah Visconti - Neptune's Net Boy
- Ashley Hamilton - Taggart
- Brooke Jaye Taylor - Happy's Nurse
- Kim Holderness - Hospital News Reporter
- Glenn Foster - Pushy Tabloid Reporter
- Anthony Reynolds - Helicopter Pilot #1
- Kendrick Cross - Helicopter Pilot #2
- Tom Clark - Reporter at House Wreckage
- Brian Schaeffer - Mandarin Studio Technician
- John Eddins - Mandarin Look-Out
- Spencer Garrett - Rose Hill Sheriff
- Rockey Dickey Jr. - Rose Hill Deputy / Extremis Soldier
- Drew Michael Hershner - Rose Hill Christmas Tree Shopper
- Sarah Burkhardt - Junior Technician
- Jan Broberg - Senior Technician
- Andrew Lauer - Satellite Technician
- Nate Bynum - Technical Director
- Andrew Lander - Vice President's Analyst
- Tom Virtue - Thomas Richards
- Roy McCrerey - President's Aide
- Serdar Kalsin - Scared Insurgent
- Demetrois Hodges - Laughing Insurgent
- Bobby Tisdale - Pageant Emcee
- Yvonne Zima - Miss Elk Ridge
- Stan Lee - Pageant Judge
- Adam Pally - Gary the Cameraman
- James Rackley - Chad Davis
- Cullen Moss - Extremis Candidate
- Jacob Dewitt - Room Service Waiter / Extremis Soldier
- Rebecca Mader - Sweat Shop Agent
- Kevin Arnold - Mandarin Guard
- Juan C. Bofill - Mandarin Guard
- David Anthony Buglione - Mandarin Guard
- Adam Lytle - Mandarin Guard
- Paul Andrew O'Connor - Mandarin Guard
- Phil Ortiz - Mandarin Guard
- Gwendalyn Barker - Sleepy Mandarin Girl
- Steve Wilder - Annoyed Mandarin Guard
- Luciana Faulhaber - Mandarin Party Girl #1
- Kary Musa - Mandarin Party Girl #2
- Mike Massa - Tony's Guard
- Mark Kubr - Ponytail Express
- Si-Fu Eric Oram - Reluctant AIM Guard
- Naomi Parshin - AIM Ping Pong Girl
- Aurelia Riley - AIM Ping Pong Girl
- Johanna Yunda - AIM Ping Pong Girl
- Wesley Thompson - Secret Service Agent
- Jenna Ortega - Vice President's Daughter
- T. C. Anyachonkeya - Iron Patriot Fan #1
- Chad Kurtz - Iron Patriot Fan #2
- Cal Johnson - Air Force One Officer
- Corey Hawkins - Navy Op
- Linden Ashby - Commander
- Sarah Farooqui - Heather
- Sala Baker - Extremis Soldier
- Kial Butler - Extremis Soldier
- Nick Brandon - Extremis Soldier
- Dan Brown - Extremis Soldier
- Fernando Chien - Extremis Soldier
- Ilram Choi - Extremis Soldier
- Brycen Counts - Extremis Soldier
- Kiante Elam - Extremis Soldier
- Dane Farwell - Extremis Soldier
- Mark Fichera - Extremis Soldier
- Colin Follenweider - Extremis Soldier
- Aja Frary - Extremis Soldier
- Mark Ginther - Extremis Soldier
- Adrian Gonzalez - Extremis Soldier
- Dennis Keiffer - Extremis Soldier
- Samuel Le - Extremis Soldier
- Tara Macken - Extremis Soldier
- William Morts - Extremis Soldier
- Jade Quon - Extremis Soldier
- J. C. Robaina - Extremis Soldier
- Markos Rounthwaite - Extremis Soldier
- Philip J. Silvera - Extremis Soldier
- Brian Simpson - Extremis Soldier
- Mark Aaron Wagner - Extremis Soldier
- Chris Gethard - Juan (uncredited)
- Nick W. Nicholson - White House Reporter (uncredited)
- Bridger Zadina - Richie (uncredited)
- Mark Ruffalo - Bruce Banner (uncredited)
- Johnny Otto - Military Advisor (uncredited)
- Toochukwu T.C. Anyachonkeya - Iron Patriot Fan #1 (as TC Anyachonkeya)
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Robert Clouse
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Robert Clouse
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Fred Weintraub
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