Basada en la obra de Brian Burrough "Public Enemies: America's Greatest Crime Wave and the Birth of the FBI, 1933-43". Narra la historia de Melvin Purvis (Christian Bale), el agente del FBI que en los años treinta dirigió la búsqueda del legendario atracador de bancos John Dillinger (Johnny Depp) y su banda.
- John Kishline - Guard Dainard
- Carey Mulligan - Carol Slayman
- James Russo - Walter Dietrich
- Giovanni Ribisi - Alvin Karpis
- Wesley Walker - Jim Leslie
- Channing Tatum - Pretty Boy Floyd
- Rory Cochrane - Agent Carter Baum
- Madison Dirks - Agent Warren Barton
- Len Bajenski - Police Chief Fultz
- Adam Clark - Sport
- Andrzej Krukowski - Oscar Lieboldt
- Casey Siemaszko - Harry Berman
- John Michael Bolger - Martin Zarkovich
- Branka Katić - Anna Sage
- Peter DeFaria - Grover Weyland
- Michael Sassone - Farmer
- Emilie de Ravin - Anna Patzke
- Ed Bruce - Senator McKellar
- Billy Crudup - J. Edgar Hoover
- Geoffrey Cantor - Harry Suydam
- Chandler Williams - Clyde Tolson
- Ben Mac Brown - Hoover Reporter #4
- Marion Cotillard - Billie Frechette
- Diana Krall - Torch Singer
- Duane Sharp - Doorman at Gold Coast
- Domenick Lombardozzi - Gilbert Catena
- Bill Camp - Frank Nitti
- John Ortiz - Phil D'Andrea
- Richard Short - Agent Sam Cowley
- Randy Ryan - Agent Julius Rice
- Shawn Hatosy - Agent John Madala
- Kurt Naebig - Agent William Rorer
- John Hoogenakker - Agent Hugh Clegg
- Adam Mucci - Agent Harold Reinecke
- Rebecca Spence - Doris Rogers
- Don Harvey - Customer at Steuben Club
- Shanyn Leigh - Helen Gillis
- Spencer Garrett - Tommy Carroll
- Stephen Lang - Charles Winstead
- Don Frye - Clarence Hurt
- Matt Craven - Gerry Campbell
- Laurence Mason - Porter at Union Station
- Lili Taylor - Sheriff Lillian Holley
- Alan Wilder - Robert Estill
- David Warshofsky - Warden Baker
- Peter Gerety - Louis Piquett
- Michael Bentt - Herbert Youngblood
- John Lister - Judge Murray
- Jim Carrane - Sam Cahoon
- John Fenner Mays - Deputy Blunk
- Rick Uecker - Edward Saager
- Craig Spidle - Reporter
- Patrick Zielinski - Doctor
- Gareth Saxe - Agent Ray Suran
- Guy Van Swearingen - Agent Ralph Brown
- Jeff Still - Jimmy Probasco
- Lance Baker - Freddie Barker
- Steve Key - Doc Barker
- Leelee Sobieski - Polly Hamilton
- Jerry Goff - Captain O'Neill
- Aaron Roman Weiner - Special Agent
- Keith Kupferer - Agent Sopsic
- Turk Muller - Other East Chicago Cop
- Tim Grimm - Other East Chicago Cop
- Martie Sanders - Irene the Ticket Taker
- Jordan Lawson - Prisoner (uncredited)
- Angelina Lyubomirova - Coat Check Girl (uncredited)
- Joel Thingvall - FBI Agent (uncredited)
- Kwame Amoaku
- Michael Waxman
- Eric Richard Lasko
- Bryan Burrough
- Ronan Bennett
- Robert De Niro
- Michael Mann
- Avy Kaufman
- Jane Rosenthal
- Bruce Tanis
- Tom Lalley
- Elliot Goldenthal
- Hugh Waddell
- Matthias Gohl
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