- Ernie Adams - Miller Huggins
- Pierre Watkin - Mr. Twitchell
- Harry Harvey - Joe McCarthy
- Bob Meusel - Robert W. Meusel (as Robert W. Meusel)
- Mark Koenig - Mark Koenig
- Bill Stern - Bill Stern
- Addison Richards - Coach
- Hardie Albright - Van Tuyl
- Edward Fielding - Clinic Doctor
- George Lessey - Mayor of New Rochelle
- Edgar Barrier - Hospital Doctor
- Douglas Croft - Lou Gehrig as a Boy
- Gene Collins - Billy (Age 8)
- David Holt - Billy (Age 17)
- Veloz - Specialty Dancer (as Veloz and Yolanda)
- Yolanda - Specialty Dancer (as Veloz and Yolanda)
- Ed Agresti - Barber (uncredited)
- Ernie Alexander - Bellhop with Flowers (uncredited)
- Hooper Atchley - Lathered Man in Barber Shop (uncredited)
- Edwin August - Restaurant Patron (uncredited)
- Becky Bohanon - Little Girl (uncredited)
- Lynton Brent - Photographer in Hospital (uncredited)
- Roy Brent - Yankee Ballplayer (uncredited)
- Betty Brewer - Little Girl (uncredited)
- Don Brodie - Girl Show Barker (uncredited)
- Charles Cane - Plumber (uncredited)
- Jack Carr - Plumber (uncredited)
- Burr Caruth - Village Storekeeper (uncredited)
- Eddy Chandler - Motorcycle Cop #2 (uncredited)
- Lane Chandler - Mark - Player in Locker Room (uncredited)
- Bill Chaney - Newsboy (uncredited)
- Jack Chapin - Photographer (uncredited)
- Janet Chapman - Tessie (uncredited)
- Spencer Charters - Mr. Larsen (uncredited)
- Dane Clark - Fraternity Boy (uncredited)
- Heinie Conklin - Wallpaper Hanger (uncredited)
- Hal Cooke - Man in Cab (uncredited)
- Clancy Cooper - Motorcycle Cop #1 (uncredited)
- John Daheim - Reporter in Hospital (uncredited)
- Eva Dennison - Mrs. Worthington (uncredited)
- Lester Dorr - Disappointed Fan #1 (uncredited)
- Peter Du Rey - Photographer in Hospital (uncredited)
- Lorna Dunn - Clinic Nurse (uncredited)
- Frank Faylen - Yankee Third Base Coach (uncredited)
- Walter Fenner - Dentist (uncredited)
- Pat Flaherty - Yankee Ballplayer (uncredited)
- Rosina Galli - Mrs. Fabrini (uncredited)
- Vaughan Glaser - Doctor in Gehrig Home (uncredited)
- Mary Gordon - Maid (uncredited)
- Herschel Graham - Spectator (uncredited)
- George Guhl - Second Paper Hanger (uncredited)
- Eddie Hall - Reporter in Hospital Room (uncredited)
- Harry Hayden - Department Store Manager (uncredited)
- Vinton Hayworth - Fraternity Boy (uncredited)
- Oscar 'Dutch' Hendrian - Furniture Mover (uncredited)
- John Hiestand - Announcer (uncredited)
- Earle Hodgins - Bottle Game Operator (uncredited)
- Fay Holderness - Spectator (uncredited)
- John Ince - Man in Box Seat (uncredited)
- Mitchell Ingraham - Barber (uncredited)
- Charles Irwin - Carnival Batting Game Operator (uncredited)
- Jack Irwin - Photographer in Hospital (uncredited)
- Sheldon Jett - Sportsman at Ballgame (uncredited)
- Payne B. Johnson - Boy in Ball Park (uncredited)
- John Kellogg - Fraternity Boy (uncredited)
- Colin Kenny - Yankee Player on Train (uncredited)
- Donald Kerr - Photographer (uncredited)
- Richard Kipling - Broker (uncredited)
- Pat Lane - Wheel of Chance Barker (uncredited)
- Larry Lawson - Barker (uncredited)
- Rex Lease - Spectator (uncredited)
- Theodore Lorch - Neighbor Leaning Through Window (uncredited)
- Wilbur Mack - Man Outside Yankee Stadium (uncredited)
- Dave Manley - Mayor Fiorello LaGuardia (uncredited)
- Maurice Marks - Player (uncredited)
- Francisco Marán - Rathskeller Headwaiter (uncredited)
- John C. McCallum - Minor Role (uncredited)
- Ralph McCullough - Reporter in Hospital (uncredited)
- George McDonald - Wally Pipp (uncredited)
- Matt McHugh - Strength Machine Operator (uncredited)
- James McNamara - Rathskeller Manager (uncredited)
- Wilmuth Merkyl - Spectator (uncredited)
- Howard M. Mitchell - Sportsman at Ballgame (uncredited)
- Irving Mitchell - Headwaiter (uncredited)
- Pat Moriarity - Policeman in 1915 (uncredited)
- Tom Neal - Fraternity Boy (uncredited)
- Ray Noble - Orchestra Leader (uncredited)
- Patsy O'Byrne - Scrubwoman (uncredited)
- George Offerman, Jr. - Freshman (uncredited)
- Garry Owen - Scorecard Vendor (uncredited)
- Sarah Padden - Mrs. Roberts (uncredited)
- Emory Parnell - Chicago Policeman O'Doul (uncredited)
- Edward Peil Sr. - Policeman (uncredited)
- Tom Quinn - Reporter in Hospital (uncredited)
- Cyril Ring - Photographer (uncredited)
- Henry Roquemore - Disappointed Fan #2 (uncredited)
- Art Rowlands - Telephone Man (uncredited)
- William Roy - Joe Fabrini (uncredited)
- Francis Sayles - Cab Driver (uncredited)
- Anita Sharp-Bolster - Sasha's Mother (uncredited)
- C. Montague Shaw - Mr. Worthington (uncredited)
- Jack Shea - Hammond (uncredited)
- John Sheehan - First Paper Hanger (uncredited)
- Jack Stewart - Ed Barrow (uncredited)
- Brick Sullivan - Policeman (uncredited)
- Ben Taggart - Conductor (uncredited)
- Walter Tetley - Cake Delivery Boy (uncredited)
- Gohr Van Vleck - Furniture Mover (uncredited)
- Dorothy Vaughan - Eleanor's Landlady (uncredited)
- Dorothy Vernon - Family Friend (uncredited)
- Malcolm Waite - Big Strength Machine Contestant (uncredited)
- James Westerfield - Spectator (uncredited)
- Guy Wilkerson - Sportsman at Ballgame (uncredited)
- Max Willenz - Mr. Colletti (uncredited)
- Charles Williams - Little Strength Machine Contestant (uncredited)
- Robert Winkler - Murphy (uncredited)
- Allen Wood - Freshman (uncredited)
- Dick Gordon - Radio Listener (uncredited)
- Charles Flynn - Fraternity Boy (uncredited)
- Sam Wood
- Paul Gallico
- Herman J. Mankiewicz
- Samuel Goldwyn
- Irving Berlin
- Fletcher Henderson
Gary Cooper hace el papel de Henry Louis 'Lou' Gehrig.
Teresa Wright interpreta a Eleanor Twitchell en la película.
Babe Ruth hace el papel de Babe Ruth.
Walter Brennan interpreta a Sam Blake en la película.
Dan Duryea hace el papel de Hank Hanneman.
Elsa Janssen interpreta a Christina 'Mom' Gehrig en la película.
Ludwig Stössel interpreta a Henry 'Pop' Gehrig en la película.
Virginia Gilmore hace el papel de Myra Tinsley.
Bill Dickey interpreta a Bill Dickey en la película.
Ernie Adams interpreta a Miller Huggins en la película.
Pierre Watkin hace el papel de Mr. Twitchell.
Harry Harvey interpreta a Joe McCarthy en la película.
Bob Meusel interpreta a Robert W. Meusel (as Robert W. Meusel) en la película.
Mark Koenig interpreta a Mark Koenig en la película.
Bill Stern interpreta a Bill Stern en la película.
Addison Richards interpreta a Coach en la película.
Hardie Albright interpreta a Van Tuyl en la película.
Edward Fielding interpreta a Clinic Doctor en la película.
George Lessey hace el papel de Mayor of New Rochelle.
Edgar Barrier interpreta a Hospital Doctor en la película.
Douglas Croft interpreta a Lou Gehrig as a Boy en la película.
Gene Collins interpreta a Billy (Age 8) en la película.
David Holt interpreta a Billy (Age 17) en la película.
Veloz interpreta a Specialty Dancer (as Veloz and Yolanda) en la película.
Yolanda hace el papel de Specialty Dancer (as Veloz and Yolanda).
Ed Agresti interpreta a Barber (uncredited) en la película.
Ernie Alexander hace el papel de Bellhop with Flowers (uncredited).
Hooper Atchley hace el papel de Lathered Man in Barber Shop (uncredited).
Edwin August interpreta a Restaurant Patron (uncredited) en la película.
Becky Bohanon interpreta a Little Girl (uncredited) en la película.
Lynton Brent hace el papel de Photographer in Hospital (uncredited).
Roy Brent hace el papel de Yankee Ballplayer (uncredited).
Betty Brewer interpreta a Little Girl (uncredited) en la película.
Don Brodie interpreta a Girl Show Barker (uncredited) en la película.
Charles Cane interpreta a Plumber (uncredited) en la película.
Jack Carr interpreta a Plumber (uncredited) en la película.
Burr Caruth interpreta a Village Storekeeper (uncredited) en la película.
Eddy Chandler interpreta a Motorcycle Cop #2 (uncredited) en la película.
Lane Chandler interpreta a Mark - Player in Locker Room (uncredited) en la película.
Bill Chaney interpreta a Newsboy (uncredited) en la película.
Jack Chapin hace el papel de Photographer (uncredited).
Janet Chapman interpreta a Tessie (uncredited) en la película.
Spencer Charters interpreta a Mr. Larsen (uncredited) en la película.
Dane Clark interpreta a Fraternity Boy (uncredited) en la película.
Heinie Conklin hace el papel de Wallpaper Hanger (uncredited).
Hal Cooke interpreta a Man in Cab (uncredited) en la película.
Clancy Cooper interpreta a Motorcycle Cop #1 (uncredited) en la película.
John Daheim interpreta a Reporter in Hospital (uncredited) en la película.
Eva Dennison hace el papel de Mrs. Worthington (uncredited).
Lester Dorr interpreta a Disappointed Fan #1 (uncredited) en la película.
Peter Du Rey interpreta a Photographer in Hospital (uncredited) en la película.
Lorna Dunn interpreta a Clinic Nurse (uncredited) en la película.
Frank Faylen interpreta a Yankee Third Base Coach (uncredited) en la película.
Walter Fenner hace el papel de Dentist (uncredited).
Pat Flaherty interpreta a Yankee Ballplayer (uncredited) en la película.
Rosina Galli interpreta a Mrs. Fabrini (uncredited) en la película.
Vaughan Glaser hace el papel de Doctor in Gehrig Home (uncredited).
Mary Gordon interpreta a Maid (uncredited) en la película.
Herschel Graham interpreta a Spectator (uncredited) en la película.
George Guhl hace el papel de Second Paper Hanger (uncredited).
Eddie Hall interpreta a Reporter in Hospital Room (uncredited) en la película.
Harry Hayden interpreta a Department Store Manager (uncredited) en la película.
Vinton Hayworth interpreta a Fraternity Boy (uncredited) en la película.
Oscar 'Dutch' Hendrian interpreta a Furniture Mover (uncredited) en la película.
John Hiestand interpreta a Announcer (uncredited) en la película.
Earle Hodgins hace el papel de Bottle Game Operator (uncredited).
Fay Holderness hace el papel de Spectator (uncredited).
John Ince interpreta a Man in Box Seat (uncredited) en la película.
Mitchell Ingraham interpreta a Barber (uncredited) en la película.
Charles Irwin interpreta a Carnival Batting Game Operator (uncredited) en la película.
Jack Irwin interpreta a Photographer in Hospital (uncredited) en la película.
Sheldon Jett interpreta a Sportsman at Ballgame (uncredited) en la película.
Payne B. Johnson hace el papel de Boy in Ball Park (uncredited).
John Kellogg hace el papel de Fraternity Boy (uncredited).
Colin Kenny interpreta a Yankee Player on Train (uncredited) en la película.
Donald Kerr interpreta a Photographer (uncredited) en la película.
Richard Kipling interpreta a Broker (uncredited) en la película.
Pat Lane interpreta a Wheel of Chance Barker (uncredited) en la película.
Larry Lawson hace el papel de Barker (uncredited).
Rex Lease hace el papel de Spectator (uncredited).
Theodore Lorch hace el papel de Neighbor Leaning Through Window (uncredited).
Wilbur Mack interpreta a Man Outside Yankee Stadium (uncredited) en la película.
Dave Manley hace el papel de Mayor Fiorello LaGuardia (uncredited).
Maurice Marks interpreta a Player (uncredited) en la película.
Francisco Marán hace el papel de Rathskeller Headwaiter (uncredited).
John C. McCallum interpreta a Minor Role (uncredited) en la película.
Ralph McCullough hace el papel de Reporter in Hospital (uncredited).
George McDonald interpreta a Wally Pipp (uncredited) en la película.
Matt McHugh interpreta a Strength Machine Operator (uncredited) en la película.
James McNamara interpreta a Rathskeller Manager (uncredited) en la película.
Wilmuth Merkyl hace el papel de Spectator (uncredited).
Howard M. Mitchell interpreta a Sportsman at Ballgame (uncredited) en la película.
Irving Mitchell hace el papel de Headwaiter (uncredited).
Pat Moriarity interpreta a Policeman in 1915 (uncredited) en la película.
Tom Neal interpreta a Fraternity Boy (uncredited) en la película.
Ray Noble interpreta a Orchestra Leader (uncredited) en la película.
Patsy O'Byrne interpreta a Scrubwoman (uncredited) en la película.
George Offerman, Jr. interpreta a Freshman (uncredited) en la película.
Garry Owen interpreta a Scorecard Vendor (uncredited) en la película.
Sarah Padden interpreta a Mrs. Roberts (uncredited) en la película.
Emory Parnell hace el papel de Chicago Policeman O'Doul (uncredited).
Edward Peil Sr. interpreta a Policeman (uncredited) en la película.
Tom Quinn interpreta a Reporter in Hospital (uncredited) en la película.
Cyril Ring hace el papel de Photographer (uncredited).
Henry Roquemore hace el papel de Disappointed Fan #2 (uncredited).
Art Rowlands interpreta a Telephone Man (uncredited) en la película.
William Roy interpreta a Joe Fabrini (uncredited) en la película.
Francis Sayles hace el papel de Cab Driver (uncredited).
Anita Sharp-Bolster hace el papel de Sasha's Mother (uncredited).
C. Montague Shaw interpreta a Mr. Worthington (uncredited) en la película.
Jack Shea interpreta a Hammond (uncredited) en la película.
John Sheehan hace el papel de First Paper Hanger (uncredited).
Jack Stewart hace el papel de Ed Barrow (uncredited).
Brick Sullivan interpreta a Policeman (uncredited) en la película.
Ben Taggart interpreta a Conductor (uncredited) en la película.
Walter Tetley interpreta a Cake Delivery Boy (uncredited) en la película.
Gohr Van Vleck interpreta a Furniture Mover (uncredited) en la película.
Dorothy Vaughan interpreta a Eleanor's Landlady (uncredited) en la película.
Dorothy Vernon hace el papel de Family Friend (uncredited).
Malcolm Waite hace el papel de Big Strength Machine Contestant (uncredited).
James Westerfield hace el papel de Spectator (uncredited).
Guy Wilkerson interpreta a Sportsman at Ballgame (uncredited) en la película.
Max Willenz hace el papel de Mr. Colletti (uncredited).
Charles Williams interpreta a Little Strength Machine Contestant (uncredited) en la película.
Robert Winkler hace el papel de Murphy (uncredited).
Allen Wood interpreta a Freshman (uncredited) en la película.
Mike Donovan interpreta a en la película.
Dick Gordon hace el papel de Radio Listener (uncredited).
Charles Flynn hace el papel de Fraternity Boy (uncredited).
Jack Gardner hace el papel de .
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