- Ernie Adams - Miller Huggins
- Pierre Watkin - Mr. Twitchell
- Harry Harvey - Joe McCarthy
- Bill Stern - Bill Stern
- Addison Richards - Coach
- Hardie Albright - Van Tuyl
- Edward Fielding - Clinic Doctor
- George Lessey - Mayor of New Rochelle
- Edgar Barrier - Hospital Doctor
- Douglas Croft - Lou Gehrig as a Boy
- Gene Collins - Billy (Age 8)
- David Holt - Billy (Age 17)
- Veloz - Specialty Dancer (as Veloz and Yolanda)
- Yolanda - Specialty Dancer (as Veloz and Yolanda)
- Ed Agresti - Barber (uncredited)
- Ernie Alexander - Bellhop with Flowers (uncredited)
- Hooper Atchley - Lathered Man in Barber Shop (uncredited)
- Edwin August - Restaurant Patron (uncredited)
- Becky Bohanon - Little Girl (uncredited)
- Lynton Brent - Photographer in Hospital (uncredited)
- Roy Brent - Yankee Ballplayer (uncredited)
- Betty Brewer - Little Girl (uncredited)
- Don Brodie - Girl Show Barker (uncredited)
- Charles Cane - Plumber (uncredited)
- Jack Carr - Plumber (uncredited)
- Burr Caruth - Village Storekeeper (uncredited)
- Eddy Chandler - Motorcycle Cop #2 (uncredited)
- Lane Chandler - Mark - Player in Locker Room (uncredited)
- Bill Chaney - Newsboy (uncredited)
- Jack Chapin - Photographer (uncredited)
- Janet Chapman - Tessie (uncredited)
- Spencer Charters - Mr. Larsen (uncredited)
- Dane Clark - Fraternity Boy (uncredited)
- Heinie Conklin - Wallpaper Hanger (uncredited)
- Clancy Cooper - Motorcycle Cop #1 (uncredited)
- John Daheim - Reporter in Hospital (uncredited)
- Eva Dennison - Mrs. Worthington (uncredited)
- Lester Dorr - Disappointed Fan #1 (uncredited)
- Frank Faylen - Yankee Third Base Coach (uncredited)
- Walter Fenner - Dentist (uncredited)
- Pat Flaherty - Yankee Ballplayer (uncredited)
- Rosina Galli - Mrs. Fabrini (uncredited)
- Vaughan Glaser - Doctor in Gehrig Home (uncredited)
- Mary Gordon - Maid (uncredited)
- Herschel Graham - Spectator (uncredited)
- George Guhl - Second Paper Hanger (uncredited)
- Eddie Hall - Reporter in Hospital Room (uncredited)
- Harry Hayden - Department Store Manager (uncredited)
- Vinton Hayworth - Fraternity Boy (uncredited)
- Oscar 'Dutch' Hendrian - Furniture Mover (uncredited)
- John Hiestand - Announcer (uncredited)
- Earle Hodgins - Bottle Game Operator (uncredited)
- Fay Holderness - Spectator (uncredited)
- John Ince - Man in Box Seat (uncredited)
- Mitchell Ingraham - Barber (uncredited)
- Charles Irwin - Carnival Batting Game Operator (uncredited)
- Sheldon Jett - Sportsman at Ballgame (uncredited)
- Payne B. Johnson - Boy in Ball Park (uncredited)
- John Kellogg - Fraternity Boy (uncredited)
- Colin Kenny - Yankee Player on Train (uncredited)
- Donald Kerr - Photographer (uncredited)
- Richard Kipling - Broker (uncredited)
- Rex Lease - Spectator (uncredited)
- Theodore Lorch - Neighbor Leaning Through Window (uncredited)
- Wilbur Mack - Man Outside Yankee Stadium (uncredited)
- Maurice Marks - Player (uncredited)
- Francisco Marán - Rathskeller Headwaiter (uncredited)
- John C. McCallum - Minor Role (uncredited)
- Ralph McCullough - Reporter in Hospital (uncredited)
- George McDonald - Wally Pipp (uncredited)
- Matt McHugh - Strength Machine Operator (uncredited)
- Wilmuth Merkyl - Spectator (uncredited)
- Howard M. Mitchell - Sportsman at Ballgame (uncredited)
- Irving Mitchell - Headwaiter (uncredited)
- Pat Moriarity - Policeman in 1915 (uncredited)
- Tom Neal - Fraternity Boy (uncredited)
- Ray Noble - Orchestra Leader (uncredited)
- Patsy O'Byrne - Scrubwoman (uncredited)
- George Offerman, Jr. - Freshman (uncredited)
- Garry Owen - Scorecard Vendor (uncredited)
- Sarah Padden - Mrs. Roberts (uncredited)
- Emory Parnell - Chicago Policeman O'Doul (uncredited)
- Edward Peil Sr. - Policeman (uncredited)
- Tom Quinn - Reporter in Hospital (uncredited)
- Cyril Ring - Photographer (uncredited)
- Henry Roquemore - Disappointed Fan #2 (uncredited)
- Art Rowlands - Telephone Man (uncredited)
- William Roy - Joe Fabrini (uncredited)
- Francis Sayles - Cab Driver (uncredited)
- Anita Sharp-Bolster - Sasha's Mother (uncredited)
- C. Montague Shaw - Mr. Worthington (uncredited)
- Jack Shea - Hammond (uncredited)
- John Sheehan - First Paper Hanger (uncredited)
- Jack Stewart - Ed Barrow (uncredited)
- Brick Sullivan - Policeman (uncredited)
- Ben Taggart - Conductor (uncredited)
- Walter Tetley - Cake Delivery Boy (uncredited)
- Gohr Van Vleck - Furniture Mover (uncredited)
- Dorothy Vaughan - Eleanor's Landlady (uncredited)
- Dorothy Vernon - Family Friend (uncredited)
- Malcolm Waite - Big Strength Machine Contestant (uncredited)
- James Westerfield - Spectator (uncredited)
- Guy Wilkerson - Sportsman at Ballgame (uncredited)
- Max Willenz - Mr. Colletti (uncredited)
- Charles Williams - Little Strength Machine Contestant (uncredited)
- Robert Winkler - Murphy (uncredited)
- Mike Donovan -
- Dick Gordon - Radio Listener (uncredited)
- Charles Flynn - Fraternity Boy (uncredited)
- Jack Gardner -
- Sam Wood
- Paul Gallico
- Herman J. Mankiewicz
- Samuel Goldwyn
- Irving Berlin
- Fletcher Henderson
Gary Cooper hace el papel de Henry Louis 'Lou' Gehrig.
Teresa Wright interpreta a Eleanor Twitchell en la película.
Babe Ruth interpreta a Babe Ruth en la película.
Walter Brennan hace el papel de Sam Blake.
Dan Duryea hace el papel de Hank Hanneman.
Elsa Janssen hace el papel de Christina 'Mom' Gehrig.
Ludwig Stössel interpreta a Henry 'Pop' Gehrig en la película.
Virginia Gilmore interpreta a Myra Tinsley en la película.
Bill Dickey interpreta a Bill Dickey en la película.
Ernie Adams interpreta a Miller Huggins en la película.
Pierre Watkin interpreta a Mr. Twitchell en la película.
Harry Harvey hace el papel de Joe McCarthy.
Bob Meusel interpreta a Robert W. Meusel (as Robert W. Meusel) en la película.
Mark Koenig hace el papel de Mark Koenig.
Bill Stern interpreta a Bill Stern en la película.
Addison Richards interpreta a Coach en la película.
Hardie Albright interpreta a Van Tuyl en la película.
Edward Fielding interpreta a Clinic Doctor en la película.
George Lessey interpreta a Mayor of New Rochelle en la película.
Edgar Barrier interpreta a Hospital Doctor en la película.
Douglas Croft hace el papel de Lou Gehrig as a Boy.
Gene Collins interpreta a Billy (Age 8) en la película.
David Holt interpreta a Billy (Age 17) en la película.
Veloz hace el papel de Specialty Dancer (as Veloz and Yolanda).
Yolanda hace el papel de Specialty Dancer (as Veloz and Yolanda).
Ed Agresti interpreta a Barber (uncredited) en la película.
Ernie Alexander hace el papel de Bellhop with Flowers (uncredited).
Hooper Atchley interpreta a Lathered Man in Barber Shop (uncredited) en la película.
Edwin August interpreta a Restaurant Patron (uncredited) en la película.
Becky Bohanon hace el papel de Little Girl (uncredited).
Lynton Brent hace el papel de Photographer in Hospital (uncredited).
Roy Brent interpreta a Yankee Ballplayer (uncredited) en la película.
Betty Brewer interpreta a Little Girl (uncredited) en la película.
Don Brodie hace el papel de Girl Show Barker (uncredited).
Charles Cane interpreta a Plumber (uncredited) en la película.
Jack Carr interpreta a Plumber (uncredited) en la película.
Burr Caruth hace el papel de Village Storekeeper (uncredited).
Eddy Chandler interpreta a Motorcycle Cop #2 (uncredited) en la película.
Lane Chandler interpreta a Mark - Player in Locker Room (uncredited) en la película.
Bill Chaney interpreta a Newsboy (uncredited) en la película.
Jack Chapin interpreta a Photographer (uncredited) en la película.
Janet Chapman interpreta a Tessie (uncredited) en la película.
Spencer Charters interpreta a Mr. Larsen (uncredited) en la película.
Dane Clark hace el papel de Fraternity Boy (uncredited).
Heinie Conklin interpreta a Wallpaper Hanger (uncredited) en la película.
Hal Cooke interpreta a Man in Cab (uncredited) en la película.
Clancy Cooper interpreta a Motorcycle Cop #1 (uncredited) en la película.
John Daheim hace el papel de Reporter in Hospital (uncredited).
Eva Dennison interpreta a Mrs. Worthington (uncredited) en la película.
Lester Dorr interpreta a Disappointed Fan #1 (uncredited) en la película.
Peter Du Rey interpreta a Photographer in Hospital (uncredited) en la película.
Lorna Dunn hace el papel de Clinic Nurse (uncredited).
Frank Faylen hace el papel de Yankee Third Base Coach (uncredited).
Walter Fenner hace el papel de Dentist (uncredited).
Pat Flaherty hace el papel de Yankee Ballplayer (uncredited).
Rosina Galli interpreta a Mrs. Fabrini (uncredited) en la película.
Vaughan Glaser hace el papel de Doctor in Gehrig Home (uncredited).
Mary Gordon hace el papel de Maid (uncredited).
Herschel Graham hace el papel de Spectator (uncredited).
George Guhl interpreta a Second Paper Hanger (uncredited) en la película.
Eddie Hall interpreta a Reporter in Hospital Room (uncredited) en la película.
Harry Hayden hace el papel de Department Store Manager (uncredited).
Vinton Hayworth interpreta a Fraternity Boy (uncredited) en la película.
Oscar 'Dutch' Hendrian interpreta a Furniture Mover (uncredited) en la película.
John Hiestand interpreta a Announcer (uncredited) en la película.
Earle Hodgins interpreta a Bottle Game Operator (uncredited) en la película.
Fay Holderness hace el papel de Spectator (uncredited).
John Ince hace el papel de Man in Box Seat (uncredited).
Mitchell Ingraham interpreta a Barber (uncredited) en la película.
Charles Irwin interpreta a Carnival Batting Game Operator (uncredited) en la película.
Jack Irwin hace el papel de Photographer in Hospital (uncredited).
Sheldon Jett interpreta a Sportsman at Ballgame (uncredited) en la película.
Payne B. Johnson interpreta a Boy in Ball Park (uncredited) en la película.
John Kellogg interpreta a Fraternity Boy (uncredited) en la película.
Colin Kenny interpreta a Yankee Player on Train (uncredited) en la película.
Donald Kerr interpreta a Photographer (uncredited) en la película.
Richard Kipling interpreta a Broker (uncredited) en la película.
Pat Lane hace el papel de Wheel of Chance Barker (uncredited).
Larry Lawson hace el papel de Barker (uncredited).
Rex Lease hace el papel de Spectator (uncredited).
Theodore Lorch hace el papel de Neighbor Leaning Through Window (uncredited).
Wilbur Mack interpreta a Man Outside Yankee Stadium (uncredited) en la película.
Dave Manley interpreta a Mayor Fiorello LaGuardia (uncredited) en la película.
Maurice Marks interpreta a Player (uncredited) en la película.
Francisco Marán hace el papel de Rathskeller Headwaiter (uncredited).
John C. McCallum interpreta a Minor Role (uncredited) en la película.
Ralph McCullough interpreta a Reporter in Hospital (uncredited) en la película.
George McDonald interpreta a Wally Pipp (uncredited) en la película.
Matt McHugh interpreta a Strength Machine Operator (uncredited) en la película.
James McNamara interpreta a Rathskeller Manager (uncredited) en la película.
Wilmuth Merkyl hace el papel de Spectator (uncredited).
Howard M. Mitchell hace el papel de Sportsman at Ballgame (uncredited).
Irving Mitchell hace el papel de Headwaiter (uncredited).
Pat Moriarity interpreta a Policeman in 1915 (uncredited) en la película.
Tom Neal hace el papel de Fraternity Boy (uncredited).
Ray Noble interpreta a Orchestra Leader (uncredited) en la película.
Patsy O'Byrne interpreta a Scrubwoman (uncredited) en la película.
George Offerman, Jr. hace el papel de Freshman (uncredited).
Garry Owen hace el papel de Scorecard Vendor (uncredited).
Sarah Padden interpreta a Mrs. Roberts (uncredited) en la película.
Emory Parnell hace el papel de Chicago Policeman O'Doul (uncredited).
Edward Peil Sr. interpreta a Policeman (uncredited) en la película.
Tom Quinn interpreta a Reporter in Hospital (uncredited) en la película.
Cyril Ring interpreta a Photographer (uncredited) en la película.
Henry Roquemore interpreta a Disappointed Fan #2 (uncredited) en la película.
Art Rowlands interpreta a Telephone Man (uncredited) en la película.
William Roy interpreta a Joe Fabrini (uncredited) en la película.
Francis Sayles interpreta a Cab Driver (uncredited) en la película.
Anita Sharp-Bolster interpreta a Sasha's Mother (uncredited) en la película.
C. Montague Shaw interpreta a Mr. Worthington (uncredited) en la película.
Jack Shea hace el papel de Hammond (uncredited).
John Sheehan hace el papel de First Paper Hanger (uncredited).
Jack Stewart hace el papel de Ed Barrow (uncredited).
Brick Sullivan hace el papel de Policeman (uncredited).
Ben Taggart hace el papel de Conductor (uncredited).
Walter Tetley interpreta a Cake Delivery Boy (uncredited) en la película.
Gohr Van Vleck interpreta a Furniture Mover (uncredited) en la película.
Dorothy Vaughan hace el papel de Eleanor's Landlady (uncredited).
Dorothy Vernon interpreta a Family Friend (uncredited) en la película.
Malcolm Waite hace el papel de Big Strength Machine Contestant (uncredited).
James Westerfield interpreta a Spectator (uncredited) en la película.
Guy Wilkerson hace el papel de Sportsman at Ballgame (uncredited).
Max Willenz interpreta a Mr. Colletti (uncredited) en la película.
Charles Williams hace el papel de Little Strength Machine Contestant (uncredited).
Robert Winkler interpreta a Murphy (uncredited) en la película.
Allen Wood interpreta a Freshman (uncredited) en la película.
Mike Donovan hace el papel de .
Dick Gordon interpreta a Radio Listener (uncredited) en la película.
Charles Flynn interpreta a Fraternity Boy (uncredited) en la película.
Jack Gardner interpreta a en la película.
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