- Vincent D'Onofrio - Orson Welles
- Mike Starr - Georgie Weiss
- Max Casella - Paul Marco
- Brent Hinkley - Conrad Brooks
- Juliet Landau - Loretta King
- Clive Rosengren - Ed Reynolds
- Norman Alden - Cameraman Bill (uncredited)
- Leonard Termo - Makeup Man Harry (uncredited)
- Ned Bellamy - Dr. Tom Mason (uncredited)
- Danny Dayton - Soundman (uncredited)
- Ross Manarchy - Camera Assistant (uncredited)
- Bill Cusack - Tony McCoy
- Stanley DeSantis - Mr. Feldman (uncredited)
- Biff Yeager - Rude Boss (uncredited)
- Joseph R. Gannascoli - Security Guard (uncredited)
- Carmen Filpi - Old Crusty Man (uncredited)
- Lisa Malkiewicz - Secretary #1 (uncredited)
- Melora Walters - Secretary #2 (uncredited)
- Conrad Brooks - Bartender (uncredited)
- Don Amendolia - Salesman (uncredited)
- Reid Cruickshanks - Stage Guard (uncredited)
- Lionel Decker - Executive #1 (uncredited)
- Edmund L. Shaff - Executive #2 (uncredited)
- Gene LeBell - Ring Announcer (uncredited)
- Bobby Slayton - TV Show Host (uncredited)
- Gretchen Becker - TV Host's Assistant (uncredited)
- John Rice - Conservative Man (uncredited)
- Catherine Butterfield - Conservative Wife (uncredited)
- Mary Portser - Backer's Wife (uncredited)
- Don Hood - Southern Backer (uncredited)
- Matthew Barry - Valet (uncredited)
- Ralph Monaco - Waiter (uncredited)
- Anthony Russell - Busboy (uncredited)
- Gregory Walcott - Potential Backer (uncredited)
- Charles C. Stevenson Jr. - Another Backer (uncredited)
- Rance Howard - Old Man McCoy (uncredited)
- Vinny Argiro - TV Horror Show Director (uncredited)
- Korla Pandit - Indian Musician (uncredited)
- Patti Tippo - Nurse (uncredited)
- Ray Baker - Doctor (uncredited)
- Louis Lombardi - Rental House Manager (uncredited)
- Jesse Hernandez - Wrestling Opponent (uncredited)
- Jim Boyce - Theatre Manager (uncredited)
- Ben Ryan Ganger - Angry Kid (uncredited)
- Charlie Holliday - Tourist (uncredited)
- Tommy Bertelsen - Tough Boy (uncredited)
- Adam Drescher - Photographer #1 (uncredited)
- Ric Mancini - Photographer #2 (uncredited)
- Daniel Riordan - Pilot / Strapping Young Man (uncredited)
- Mickey Cottrell - Hammy Alien (uncredited)
- Maurice LaMarche - Orson Welles (voice) (uncredited)
- Ada Tai - Vampira's Friend (uncredited)
- Rayder Woods - Car Vandal (uncredited)
- Ralph Moratz - Extra (uncredited)
- Tim Burton
- Rudolph Grey
- Scott Alexander
- Larry Karaszewski
- Tim Burton
- Victoria Thomas
- Denise Di Novi
- Michael Lehmann
- Bill Dance
- Howard Shore
- Ellen Segal
- John Nutt
- Mildred Iatrou
- Margie O'Malley
- Ernie Fosselius
Johnny Depp interpreta a Ed Wood en la película.
Martin Landau interpreta a Bela Lugosi en la película.
Sarah Jessica Parker interpreta a Dolores Fuller en la película.
Patricia Arquette interpreta a Kathy O'Hara en la película.
Jeffrey Jones hace el papel de Criswell.
Bill Murray hace el papel de Bunny Breckinridge.
Lisa Marie hace el papel de Vampira.
Jim Myers interpreta a Tor Johnson en la película.
G. D. Spradlin interpreta a Reverend Lemon en la película.
Vincent D'Onofrio interpreta a Orson Welles en la película.
Mike Starr interpreta a Georgie Weiss en la película.
Max Casella interpreta a Paul Marco en la película.
Brent Hinkley hace el papel de Conrad Brooks.
Juliet Landau hace el papel de Loretta King.
Clive Rosengren hace el papel de Ed Reynolds.
Norman Alden interpreta a Cameraman Bill (uncredited) en la película.
Leonard Termo hace el papel de Makeup Man Harry (uncredited).
Ned Bellamy hace el papel de Dr. Tom Mason (uncredited).
Danny Dayton hace el papel de Soundman (uncredited).
Ross Manarchy interpreta a Camera Assistant (uncredited) en la película.
Bill Cusack hace el papel de Tony McCoy.
Stanley DeSantis interpreta a Mr. Feldman (uncredited) en la película.
Biff Yeager interpreta a Rude Boss (uncredited) en la película.
Joseph R. Gannascoli interpreta a Security Guard (uncredited) en la película.
Carmen Filpi interpreta a Old Crusty Man (uncredited) en la película.
Lisa Malkiewicz interpreta a Secretary #1 (uncredited) en la película.
Melora Walters interpreta a Secretary #2 (uncredited) en la película.
Conrad Brooks interpreta a Bartender (uncredited) en la película.
Don Amendolia interpreta a Salesman (uncredited) en la película.
Reid Cruickshanks interpreta a Stage Guard (uncredited) en la película.
Lionel Decker interpreta a Executive #1 (uncredited) en la película.
Edmund L. Shaff hace el papel de Executive #2 (uncredited).
Gene LeBell interpreta a Ring Announcer (uncredited) en la película.
Bobby Slayton interpreta a TV Show Host (uncredited) en la película.
Gretchen Becker interpreta a TV Host's Assistant (uncredited) en la película.
John Rice interpreta a Conservative Man (uncredited) en la película.
Catherine Butterfield hace el papel de Conservative Wife (uncredited).
Mary Portser interpreta a Backer's Wife (uncredited) en la película.
King Cotton hace el papel de Hick Backer (uncredited).
Don Hood interpreta a Southern Backer (uncredited) en la película.
Matthew Barry interpreta a Valet (uncredited) en la película.
Ralph Monaco hace el papel de Waiter (uncredited).
Anthony Russell hace el papel de Busboy (uncredited).
Gregory Walcott interpreta a Potential Backer (uncredited) en la película.
Charles C. Stevenson Jr. interpreta a Another Backer (uncredited) en la película.
Rance Howard hace el papel de Old Man McCoy (uncredited).
Vasek Simek interpreta a Professor Strowski (uncredited) en la película.
Vinny Argiro interpreta a TV Horror Show Director (uncredited) en la película.
Korla Pandit hace el papel de Indian Musician (uncredited).
Patti Tippo hace el papel de Nurse (uncredited).
Ray Baker hace el papel de Doctor (uncredited).
Louis Lombardi interpreta a Rental House Manager (uncredited) en la película.
Jesse Hernandez hace el papel de Wrestling Opponent (uncredited).
Jim Boyce interpreta a Theatre Manager (uncredited) en la película.
Ben Ryan Ganger interpreta a Angry Kid (uncredited) en la película.
Charlie Holliday interpreta a Tourist (uncredited) en la película.
Tommy Bertelsen hace el papel de Tough Boy (uncredited).
Adam Drescher interpreta a Photographer #1 (uncredited) en la película.
Ric Mancini hace el papel de Photographer #2 (uncredited).
Daniel Riordan hace el papel de Pilot / Strapping Young Man (uncredited).
Mickey Cottrell interpreta a Hammy Alien (uncredited) en la película.
Lena Banks interpreta a Sexy Pedestrian (uncredited) en la película.
Maurice LaMarche hace el papel de Orson Welles (voice) (uncredited).
Ada Tai interpreta a Vampira's Friend (uncredited) en la película.
Arlene Tai interpreta a Vampira's Friend (uncredited) en la película.
Rayder Woods interpreta a Car Vandal (uncredited) en la película.
Ralph Moratz interpreta a Extra (uncredited) en la película.
Bill Blair hace el papel de Carny (uncredited).
Ryan Holihan hace el papel de Frantic Usher.
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