- Vincent D'Onofrio - Orson Welles
- Mike Starr - Georgie Weiss
- Max Casella - Paul Marco
- Brent Hinkley - Conrad Brooks
- Juliet Landau - Loretta King
- Clive Rosengren - Ed Reynolds
- Norman Alden - Cameraman Bill (uncredited)
- Leonard Termo - Makeup Man Harry (uncredited)
- Ned Bellamy - Dr. Tom Mason (uncredited)
- Danny Dayton - Soundman (uncredited)
- Ross Manarchy - Camera Assistant (uncredited)
- Bill Cusack - Tony McCoy
- Stanley DeSantis - Mr. Feldman (uncredited)
- Biff Yeager - Rude Boss (uncredited)
- Joseph R. Gannascoli - Security Guard (uncredited)
- Carmen Filpi - Old Crusty Man (uncredited)
- Lisa Malkiewicz - Secretary #1 (uncredited)
- Melora Walters - Secretary #2 (uncredited)
- Conrad Brooks - Bartender (uncredited)
- Don Amendolia - Salesman (uncredited)
- Reid Cruickshanks - Stage Guard (uncredited)
- Lionel Decker - Executive #1 (uncredited)
- Edmund L. Shaff - Executive #2 (uncredited)
- Gene LeBell - Ring Announcer (uncredited)
- Bobby Slayton - TV Show Host (uncredited)
- Gretchen Becker - TV Host's Assistant (uncredited)
- John Rice - Conservative Man (uncredited)
- Catherine Butterfield - Conservative Wife (uncredited)
- Mary Portser - Backer's Wife (uncredited)
- King Cotton - Hick Backer (uncredited)
- Don Hood - Southern Backer (uncredited)
- Matthew Barry - Valet (uncredited)
- Ralph Monaco - Waiter (uncredited)
- Anthony Russell - Busboy (uncredited)
- Gregory Walcott - Potential Backer (uncredited)
- Charles C. Stevenson Jr. - Another Backer (uncredited)
- Rance Howard - Old Man McCoy (uncredited)
- Vasek Simek - Professor Strowski (uncredited)
- Vinny Argiro - TV Horror Show Director (uncredited)
- Korla Pandit - Indian Musician (uncredited)
- Patti Tippo - Nurse (uncredited)
- Ray Baker - Doctor (uncredited)
- Louis Lombardi - Rental House Manager (uncredited)
- Jesse Hernandez - Wrestling Opponent (uncredited)
- Jim Boyce - Theatre Manager (uncredited)
- Ben Ryan Ganger - Angry Kid (uncredited)
- Charlie Holliday - Tourist (uncredited)
- Tommy Bertelsen - Tough Boy (uncredited)
- Adam Drescher - Photographer #1 (uncredited)
- Ric Mancini - Photographer #2 (uncredited)
- Daniel Riordan - Pilot / Strapping Young Man (uncredited)
- Mickey Cottrell - Hammy Alien (uncredited)
- Lena Banks - Sexy Pedestrian (uncredited)
- Maurice LaMarche - Orson Welles (voice) (uncredited)
- Ada Tai - Vampira's Friend (uncredited)
- Arlene Tai - Vampira's Friend (uncredited)
- Rayder Woods - Car Vandal (uncredited)
- Ralph Moratz - Extra (uncredited)
- Bill Blair - Carny (uncredited)
- Ryan Holihan - Frantic Usher
- Tim Burton
- Rudolph Grey
- Scott Alexander
- Larry Karaszewski
- Tim Burton
- Victoria Thomas
- Denise Di Novi
- Michael Lehmann
- Bill Dance
- Howard Shore
- Ellen Segal
- John Nutt
- Mildred Iatrou
- Margie O'Malley
- Ernie Fosselius
Johnny Depp interpreta a Ed Wood en la película.
Martin Landau interpreta a Bela Lugosi en la película.
Sarah Jessica Parker hace el papel de Dolores Fuller.
Patricia Arquette interpreta a Kathy O'Hara en la película.
Jeffrey Jones interpreta a Criswell en la película.
Bill Murray interpreta a Bunny Breckinridge en la película.
Lisa Marie interpreta a Vampira en la película.
Jim Myers interpreta a Tor Johnson en la película.
G. D. Spradlin interpreta a Reverend Lemon en la película.
Vincent D'Onofrio interpreta a Orson Welles en la película.
Mike Starr interpreta a Georgie Weiss en la película.
Max Casella hace el papel de Paul Marco.
Brent Hinkley hace el papel de Conrad Brooks.
Juliet Landau interpreta a Loretta King en la película.
Clive Rosengren hace el papel de Ed Reynolds.
Norman Alden hace el papel de Cameraman Bill (uncredited).
Leonard Termo hace el papel de Makeup Man Harry (uncredited).
Ned Bellamy hace el papel de Dr. Tom Mason (uncredited).
Danny Dayton interpreta a Soundman (uncredited) en la película.
Ross Manarchy hace el papel de Camera Assistant (uncredited).
Bill Cusack interpreta a Tony McCoy en la película.
Stanley DeSantis interpreta a Mr. Feldman (uncredited) en la película.
Biff Yeager interpreta a Rude Boss (uncredited) en la película.
Joseph R. Gannascoli hace el papel de Security Guard (uncredited).
Carmen Filpi interpreta a Old Crusty Man (uncredited) en la película.
Lisa Malkiewicz interpreta a Secretary #1 (uncredited) en la película.
Melora Walters hace el papel de Secretary #2 (uncredited).
Conrad Brooks interpreta a Bartender (uncredited) en la película.
Don Amendolia interpreta a Salesman (uncredited) en la película.
Reid Cruickshanks hace el papel de Stage Guard (uncredited).
Lionel Decker hace el papel de Executive #1 (uncredited).
Edmund L. Shaff interpreta a Executive #2 (uncredited) en la película.
Gene LeBell hace el papel de Ring Announcer (uncredited).
Bobby Slayton interpreta a TV Show Host (uncredited) en la película.
Gretchen Becker interpreta a TV Host's Assistant (uncredited) en la película.
John Rice interpreta a Conservative Man (uncredited) en la película.
Catherine Butterfield hace el papel de Conservative Wife (uncredited).
Mary Portser interpreta a Backer's Wife (uncredited) en la película.
King Cotton hace el papel de Hick Backer (uncredited).
Don Hood interpreta a Southern Backer (uncredited) en la película.
Matthew Barry interpreta a Valet (uncredited) en la película.
Ralph Monaco interpreta a Waiter (uncredited) en la película.
Anthony Russell interpreta a Busboy (uncredited) en la película.
Gregory Walcott interpreta a Potential Backer (uncredited) en la película.
Charles C. Stevenson Jr. hace el papel de Another Backer (uncredited).
Rance Howard hace el papel de Old Man McCoy (uncredited).
Vasek Simek interpreta a Professor Strowski (uncredited) en la película.
Vinny Argiro interpreta a TV Horror Show Director (uncredited) en la película.
Korla Pandit hace el papel de Indian Musician (uncredited).
Patti Tippo interpreta a Nurse (uncredited) en la película.
Ray Baker hace el papel de Doctor (uncredited).
Louis Lombardi hace el papel de Rental House Manager (uncredited).
Jesse Hernandez interpreta a Wrestling Opponent (uncredited) en la película.
Jim Boyce interpreta a Theatre Manager (uncredited) en la película.
Ben Ryan Ganger hace el papel de Angry Kid (uncredited).
Charlie Holliday hace el papel de Tourist (uncredited).
Tommy Bertelsen interpreta a Tough Boy (uncredited) en la película.
Adam Drescher hace el papel de Photographer #1 (uncredited).
Ric Mancini interpreta a Photographer #2 (uncredited) en la película.
Daniel Riordan hace el papel de Pilot / Strapping Young Man (uncredited).
Mickey Cottrell interpreta a Hammy Alien (uncredited) en la película.
Lena Banks interpreta a Sexy Pedestrian (uncredited) en la película.
Maurice LaMarche hace el papel de Orson Welles (voice) (uncredited).
Ada Tai interpreta a Vampira's Friend (uncredited) en la película.
Arlene Tai interpreta a Vampira's Friend (uncredited) en la película.
Rayder Woods interpreta a Car Vandal (uncredited) en la película.
Ralph Moratz interpreta a Extra (uncredited) en la película.
Bill Blair hace el papel de Carny (uncredited).
Ryan Holihan interpreta a Frantic Usher en la película.
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