- Paul Rhys - Dr. Ferral
- Lesley Sharp - Kate Eddowes
- Estelle Skornik - Ada
- Nicholas McGaughey - Officer Bolt
- Annabelle Apsion - Polly
- Joanna Page - Ann Crook
- Mark Dexter - Albert Sickert / Prince Edward Albert Victor
- Danny Midwinter - Constable Withers
- Samantha Spiro - Martha Tabram
- David Schofield - McQueen
- Bryon Fear - Robert Best
- Peter Eyre - Lord Hallsham
- Cliff Parisi - Mac Bartender
- Sophia Myles - Victoria Abberline
- Ralph Ineson - Gordie
- Amy Huck - Gull's Maid
- Rupert Farley - Doss Landlord
- Donald Douglas - Hospital Director
- John Owens - Marylebone Governor
- Liz Moscrop - Queen Victoria
- Ian McNeice - Robert Drudge
- Steve John Shepherd - Special Branch Constable
- Al Hunter Ashton - Stonecutter
- Poppy Rogers - Alice Crook
- Bruce Byron - Ann Crook's Father
- Melanie Hill - Ann Crook's Mother
- Andy Linden - Carpenter
- David Fisher - Carpenter / Letter Writer
- Gary Powell - Constable #1
- Steve Chaplin - Constable #2
- Vincent Franklin - George Lusk
- Louise Atkins - Bold Hooker
- Anthony Parker - John Merrick
- James Greene - Masonic Governor
- Dominic Cooper - Constable #3
- Carey Thring - Police Photographer
- Vladimír Kulhavý - Rag & Bone Man
- Graham Kent - Records Clerk
- Rupert Holliday-Evans - Sailor
- Simon Harrison - Thomas Bond
- Paul Moody - Young Doctor
- Glen Berry - Young Labourer
- Charles Parish - Labourer #2
- Gerry Grenn - Funeral Minister / Letter Writer
- Albert Hughes
- Allen Hughes
- Susan Lambie
- Alan Moore
- Terry Hayes
- Amy Robinson
- Jane Hamsher
- Don Murphy
- Albert Hughes
- Allen Hughes
- Joyce Gallie
- Steve Boeddeker
- Tim Gomillion
- Paul Massey
- Dennis Rogers
- Alicia Stevenson
- Doug Hemphill
Capítulo disponible en las siguientes plataformas: