- Josie Sedgwick-Davies - Frizzle (voice)
- Peter Serafinowicz - Reginald Smith (voice)
- Nick Mohammed - Dr Fry (voice)
- Miranda Richardson - Mrs Tweedy (voice)
- David Brooks - Burly Guard (voice)
- Dan Williamson - Van Driver (voice)
- Tom Doggart - 2D Narrator / Male Guards (voice)
- Sam Fell - 2D Animated Boy / Dying Moth (voice)
- Naomi McDonald - 2D Animated Mum / Beryl / Chicken 314 (voice)
- Kate Harbour - Biscuit Chicken / Female Guards (voice)
- Tim Bentinck - Gate Guard / Additional Voices (voice)
- Sophie Smith - Snail (voice)
- Ramanique Ahluwalia - Additional Voices (voice)
- Abigail Andjel - Additional Voices (voice)
- Sudha Bhuchar - Additional Voices (voice)
- Angela Christofilou - Additional Voices (voice)
- Sarah Counsell - Additional Voices (voice)
- Nicole Davis - Additional Voices (voice)
- Alison Dowling - Additional Voices (voice)
- Lillie Flynn - Additional Voices (voice)
- Matthew Gammie - Additional Voices (voice)
- Rebecca Gethings - Additional Voices (voice)
- Rebekah Hinds - Additional Voices (voice)
- Shobu Kapoor - Additional Voices (voice)
- Amy McAllister - Additional Voices (voice)
- Harry McEntire - Additional Voices (voice)
- Willow Nash - Additional Voices (voice)
- Dami Olukoya - Additional Voices (voice)
- Tamaryn Payne - Additional Voices (voice)
- Elizabeth Price - Additional Voices (voice)
- William Vanderpuye - Additional Voices (voice)
- Joan Walker - Additional Voices (voice)
- Sam Wilkinson - Additional Voices (voice)
- Dean Williamson - Additional Voices (voice)
- Becky Wright - Additional Voices (voice)
- Amina Zia - Additional Voices (voice)
- Sam Fell
- Karey Kirkpatrick
- Karey Kirkpatrick
- John O'Farrell
- John O'Farrell
- Peter Peake
- Patsy Pollock
- Nick Park
- Karey Kirkpatrick
- Peter Lord
- David Sproxton
- Sam Fell
- Harry Gregson-Williams
- Dillon Bennett
Thandiwe Newton interpreta a Ginger (voice) en la película.
Zachary Levi interpreta a Rocky (voice) en la película.
Bella Ramsey interpreta a Molly (voice) en la película.
Imelda Staunton interpreta a Bunty (voice) en la película.
Lynn Ferguson interpreta a Mac (voice) en la película.
David Bradley hace el papel de Fowler (voice).
Jane Horrocks interpreta a Babs (voice) en la película.
Romesh Ranganathan interpreta a Nick (voice) en la película.
Daniel Mays interpreta a Fetcher (voice) en la película.
Josie Sedgwick-Davies interpreta a Frizzle (voice) en la película.
Peter Serafinowicz hace el papel de Reginald Smith (voice).
Nick Mohammed interpreta a Dr Fry (voice) en la película.
Miranda Richardson interpreta a Mrs Tweedy (voice) en la película.
David Brooks interpreta a Burly Guard (voice) en la película.
Dan Williamson interpreta a Van Driver (voice) en la película.
Tom Doggart hace el papel de 2D Narrator / Male Guards (voice).
Sam Fell hace el papel de 2D Animated Boy / Dying Moth (voice).
Naomi McDonald interpreta a 2D Animated Mum / Beryl / Chicken 314 (voice) en la película.
Kate Harbour interpreta a Biscuit Chicken / Female Guards (voice) en la película.
Tim Bentinck hace el papel de Gate Guard / Additional Voices (voice).
Sophie Smith interpreta a Snail (voice) en la película.
Ramanique Ahluwalia interpreta a Additional Voices (voice) en la película.
Abigail Andjel interpreta a Additional Voices (voice) en la película.
Sudha Bhuchar interpreta a Additional Voices (voice) en la película.
Angela Christofilou hace el papel de Additional Voices (voice).
Sarah Counsell hace el papel de Additional Voices (voice).
Nicole Davis hace el papel de Additional Voices (voice).
Alison Dowling hace el papel de Additional Voices (voice).
Lillie Flynn interpreta a Additional Voices (voice) en la película.
Matthew Gammie interpreta a Additional Voices (voice) en la película.
Rebecca Gethings interpreta a Additional Voices (voice) en la película.
Rebekah Hinds hace el papel de Additional Voices (voice).
Shobu Kapoor hace el papel de Additional Voices (voice).
Amy McAllister hace el papel de Additional Voices (voice).
Harry McEntire hace el papel de Additional Voices (voice).
Willow Nash interpreta a Additional Voices (voice) en la película.
Dami Olukoya interpreta a Additional Voices (voice) en la película.
Tamaryn Payne interpreta a Additional Voices (voice) en la película.
Elizabeth Price interpreta a Additional Voices (voice) en la película.
William Vanderpuye interpreta a Additional Voices (voice) en la película.
Joan Walker hace el papel de Additional Voices (voice).
Sam Wilkinson hace el papel de Additional Voices (voice).
Dean Williamson hace el papel de Additional Voices (voice).
Becky Wright hace el papel de Additional Voices (voice).
Amina Zia interpreta a Additional Voices (voice) en la película.
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