- Jack Dylan Grazer - 12-Year-Old Nic Sheff
- Kue Lawrence - 5-Year-Old Nic Sheff
- Timothy Hutton - Dr. Brown
- Amy Forsyth - Diane
- Andre Royo - Spencer
- Ricky Low - Destiny
- LisaGay Hamilton - Rose
- Carlton Wilborn - Vince
- Amy Aquino - Annie Goldblum
- Marypat Farrell - Julia's Mother
- Brandon James Cienfuegos - Kid
- Anastasia Leddick - Speaker @ 12 Step Meeting
- Edward Fletcher - Minister
- Justin Townes Earle - Wedding Guest
- Seann Gallagher - Father @ Graduation
- Tom Beyer - Meeting Leader
- David Mendenhall - Rocker (uncredited)
- George Bamber
- Felix van Groeningen
- David Townsend
- Francine Maisler
- Brad Pitt
- Rob Swanson
- Amber Wakefield
- John Panzarella
- Jason Oliver
- Darrin Mann
- Katherine Rose
- Phil Lee
- Gabe Hilfer
- Marc Glassman
Capítulo disponible en las siguientes plataformas: