- Nestor Serrano - Dr. Hazmat
- Cynthia Roman - Rose
- Sonja Sohn - Kanita
- Arthur J. Nascarella - Captain Barney
- Queen Latifah - Dispatcher Love (voice)
- Michael Kenneth Williams - Drug Dealer
- Craig muMs Grant - Voice in Crowd
- John Heffernan - Mr. Oh
- Judy Reyes - ICU Nurse
- Afemo Omilami - Griss
- Cullen O. Johnson - Mr. Burke
- Julyana Soelistyo - Sister Fetus
- Graciela Lecube - Neighbor Woman
- Marylouise Burke - Neighbor Woman
- Phyllis Somerville - Mrs. Burke
- Mary Diveny - Neighbor Woman
- Tom Riis Farrell - John Burke
- Aleks Shaklin - Arguing Russian
- Leonid Citer - Arguing Russian
- Jesus A. Del Rosario Jr. - Man with Bloody Foot
- Bernie Friedman - Big Feet
- Theo Kogan - Prostitute
- Fuschia! - Prostitute
- Matthew Maher - Mr. Oh's Friend
- Bronson Dudley - Mr. Oh's Friend
- Marilyn McDonald - Mr. Oh's Friend
- Ed Jupp Jr. - Homeless Man in Waiting Room
- J. Stanford Hoffman - Homeless Man in Waiting Room
- Rita Norona Schrager - Concerned Hispanic Aunt
- Don Berry - Naked Man
- Mtume Gant - Street Punk
- Michael A. Noto - Grunt
- Omar Scroggins - Bystander
- Andy Davoli - Stanley
- Charlene Hunter - Miss Williams
- Jesse Malin - Club Doorman
- Harper Simon - I.B. Bangin'
- Joseph Monroe Webb - Drummer
- Jon Abrahams - Club Bystander
- Charis Michelsen - I.B.'s Girlfriend
- Lia Yang - Dr. Milagros
- Antone Pagán - Arrested Man
- Melissa Marsala - Bridge & Tunnel Girl
- Betty Miller - Weeping Woman
- Rosemary Gomez - Pregnant Maria
- Luis Rodriguez - Carlos
- Sylva Kelegian - Crackhead
- Frank Ciornei - Dr. Mishra
- Catrina Ganey - Nurse Odette
- Jennifer Lane Newman - Nurse Advisor
- John Bal - Police in Hospital
- Raymond Cassar - Police in Hospital
- Tom Cappadona - Drunk
- Jack O'Connell - Drunk
- Randy Foster - Drunk
- Richard Spore - Homeless Suicidal
- James Hanlon - Fireman
- Chris Edwards - Fireman
- Mark Giordano - Police Sergeant
- Michael Mulheren - Cop in Elevator
- David Zayas - Cop in Elevator
- Terry Serpico - Cop #1
- Floyd Resnick - Cop #3
- Megan Leigh - Surgeon
- David Vasquez - Screaming Man
- Peju Bamgboshe - Child Zombie (uncredited)
- Carolyn Campbell - Policewoman (uncredited)
- Michael Carbonaro - Club Kid (uncredited)
- Martin Scorsese
- Joseph P. Reidy
- Paul Schrader
- Barbara De Fina
- Bruce Winant
- Jeff Levine
- Erica Bamforth
- Scott Rudin
- Damon Michael Gordon
- Elmer Bernstein
- George A. Lara
- Marko Costanzo
- Marissa Littlefield
Capítulo disponible en las siguientes plataformas:
