- Michael Kenneth Williams - Robert
- Alfre Woodard - Mistress Shaw
- Chris Chalk - Clemens
- Taran Killam - Hamilton
- Bill Camp - Radburn
- Kelsey Scott - Anne Northup
- Bryan Batt - Judge Turner
- Quvenzhané Wallis - Margaret Northup
- Garret Dillahunt - Armsby
- Dwight Henry - Uncle Abram
- Dickie Gravois - Overseer
- Ashley Dyke - Anna
- Cameron Zeigler - Alonzo Northup
- Tony Bentley - Mr. Moon
- Christopher Berry - Burch
- Mister Mackey Jr. - Randall
- Craig Tate - John
- Storm Reid - Emily
- Tom Proctor - Biddee
- Marc Macaulay - Captain
- Vivian Fleming-Alvarez - Mulatto Woman
- Douglas M. Griffin - Sailor
- John McConnell - Jonus Ray
- Marcus Lyle Brown - Jasper
- Richard Holden - Fitzgerald
- Rob Steinberg - Parker
- Anwan Glover - Cape
- James C. Victor - Buyer
- Liza J. Bennett - Mistress Ford
- Nicole Collins - Rachel
- J.D. Evermore - Chapin
- Andy Dylan - Treach
- Deneen Tyler - Phebe
- Mustafa Harris - Sam
- Gregory Bright - Edward
- Austin Purnell - Bob
- Thomas Francis Murphy - Patroller
- Andre De'Sean Shanks - Victim 1
- Kelvin Harrison Jr. - Victim 2
- Scott M. Jefferson - Master Shaw
- Isaiah Jackson - Zachary
- Topsy Chapman - Slave Spiritual Singer 1
- Devin Maurice Evans - Slave Spiritual Singer 2
- Jay Huguley - Sheriff
- Devyn A. Tyler - Margaret Northup (adult)
- Willo Jean-Baptiste - Margaret's Husband
- Jason Ament - Cooke (uncredited)
- Jon Arthur - Steamboat Crew 1st Mate (uncredited)
- Sean Paul Braud - Lynchman (uncredited)
- Blake Burt - Upper Class Pedestrian (uncredited)
- Carroll Burt - Lower Class Pedestrian (uncredited)
- Edward J. Clare - Restaurant Patron (uncredited)
- JJ Coker - Mr. Bartholomew (uncredited)
- Haylie Creppel - Child in the Park (uncredited)
- Justin Edward Davis - Saratoga Park Pedestrian (uncredited)
- Jim Johnson - Lower Class Pedestrian (uncredited)
- Mark Joyce - Street Merchant (uncredited)
- John C. Klein - Lumber Mill Customer (uncredited)
- Gerard 'Jerry' Lewis - Slave Guard (uncredited)
- Kevonte Mcdonald - Slave (uncredited)
- Ritchie Montgomery - Roadman (uncredited)
- Jason Owen - Safty (uncredited)
- Shawn Parsons - Road Man (uncredited)
- Haley Powell - Slave Girl (uncredited)
- Wayne Pére - Winslow (uncredited)
- Terrell Ransom Jr. - Slave Boy (uncredited)
- Erin Rementer - Ballroom Dancer (uncredited)
- Andre Robinson - Slave Boy (uncredited)
- Jarett Shorts - Hornboy (uncredited)
- Chaz Smith - Cigar Smoker (uncredited)
- Tyler Soerries - Boy Playing in Park (uncredited)
- Tre Tureaud - Saratoga Park Pedestrians (uncredited)
- Justin Christopher Vaughn - Ezra (uncredited)
- Bob Walker - Abolitionist Landowner (uncredited)
- Caroline Grace Williamson - Ford Daughter (uncredited)
- Timothy Wyant - Ford Lumber Buyer (uncredited)
- Doug Torres
-
John Ridley
- Francine Maisler
- Anthony Katagas
- Brad Pitt
- Steve McQueen
- Arnon Milchan
- Tessa Ross
- Ryan Collins
- Hans Zimmer
- Ellen Heuer
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